Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis

scholarly article

Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2008PNAS..105.2349B
P356DOI10.1073/PNAS.0712227105
P932PMC publication ID2268139
P698PubMed publication ID18268345
P5875ResearchGate publication ID5584503

P50authorSolomon Halbert SnyderQ1681665
Adam C ResnickQ101061596
Rashna BhandariQ26000239
P2093author name stringKrishna R Juluri
P2860cites workMolecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
Phenotypic alterations in insulin-deficient mutant mice.Q36766264
Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.Q38299578
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Q40474530
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Vesicular traffic and golgi apparatus dynamics during mammalian spermatogenesis: implications for acrosome architectureQ40873001
Reproductive abnormalities in human insulin-like growth factor-binding protein-1 transgenic male miceQ42455629
Role of phosphoinositide signaling in the control of insulin exocytosisQ42482214
Inositol diphosphate signaling regulates telomere lengthQ42641267
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2Q43913945
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Role of brain insulin receptor in control of body weight and reproductionQ47229086
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificityQ79271161
Extraction and analysis of soluble inositol polyphosphates from yeastQ80093282
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesisQ27930910
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinaseQ28138219
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasiaQ28143642
The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitusQ28268909
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinaseQ28280529
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinaseQ28280540
The versatility and universality of calcium signallingQ29547402
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Perspective: male reproductionQ34253332
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man.Q34643925
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Inositol pyrophosphates: metabolism and signalingQ36375032
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2349-2353
P577publication date2008-02-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis
P478volume105

Reverse relations

cites work (P2860)
Q42161635A scalable synthesis of the IP7 isomer, 5-PP-Ins(1,2,3,4,6)P5.
Q41679412Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis
Q38194549Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
Q27007488Biosynthesis and possible functions of inositol pyrophosphates in plants
Q41549123Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.
Q38841684Chemical pyrophosphorylation of functionally diverse peptides.
Q38837404Chemical tools for interrogating inositol pyrophosphate structure and function.
Q36835730Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate
Q37020337Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice
Q37268113Diphosphoinositol polyphosphates: metabolic messengers?
Q35676308Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
Q35208535Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma
Q38433610Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain
Q28540195Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response
Q27684442IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
Q48028376IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids
Q51847806Influence of inositol pyrophosphates on cellular energy dynamics.
Q36898165Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells
Q37219919Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice
Q64947264Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.
Q36176216Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.
Q59604012Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
Q37394301Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Q52664251Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Q41830941Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
Q38437282Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis
Q34526364Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death
Q44273064Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways
Q30497487Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway
Q41820993Inositol hexakisphosphate kinases induce cell death in Huntington disease
Q37398176Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.
Q37482212Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release
Q36579532Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair
Q37186675Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis
Q36886772Inositol pyrophosphates as mammalian cell signals
Q42053859Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
Q33570316Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2
Q37340761Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Q38110945Inositol pyrophosphates: between signalling and metabolism
Q37588509Inositol pyrophosphates: structure, enzymology and function
Q41841387Insulin signaling: inositol phosphates get into the Akt.
Q39329205Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.
Q34097426Metabolomics Reveals Relationship between Plasma Inositols and Birth Weight: Possible Markers for Fetal Programming of Type 2 Diabetes
Q54979724Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.
Q53076766Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
Q42318137Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.
Q64266884Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line
Q47637691Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
Q41673085Protein pyrophosphorylation: moving forward
Q24599387Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes
Q27011244Structural insight into inositol pyrophosphate turnover
Q43074238Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.
Q38435784TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Q90597925Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Q26786441The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
Q26851038The enzymes of human diphosphoinositol polyphosphate metabolism
Q92666397The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
Q47250401The inositol pyrophosphate pathway in health and diseases
Q37805097The signaling role of inositol hexakisphosphate kinases (IP6Ks)
Q38728101Towards pharmacological intervention in inositol pyrophosphate signalling
Q57145863Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors
Q34397020p53-mediated apoptosis requires inositol hexakisphosphate kinase-2

Search more.