Inositol pyrophosphates: structure, enzymology and function

scientific article published on 28 August 2009

Inositol pyrophosphates: structure, enzymology and function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-009-0115-2
P698PubMed publication ID19714294

P50authorPer-Olof BerggrenQ5571984
P2093author name stringChristopher Illies
Christopher John Barker
Gian Carlo Gaboardi
P2860cites workCloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolasesQ21284394
Towards a proteome-scale map of the human protein–protein interaction networkQ21735930
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type proteinQ22010421
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphatesQ22010877
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt familyQ22253958
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factorQ24299223
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Specific interaction of Golgi coatomer protein alpha-COP with phosphatidylinositol 3,4,5-trisphosphateQ74392954
Diphospho-myo-inositol phosphates in Dictyostelium and Polysphondylium: identification of a new bisdiphospho-myo-inositol tetrakisphosphateQ74582960
Inositol trisphosphate and calcium oscillationsQ79593855
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionQ24304442
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cellsQ24530557
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphataseQ24530579
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
A quantitative atlas of mitotic phosphorylationQ24646817
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activationQ24670467
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
The exosome and RNA quality control in the nucleusQ24681595
The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)Q27639186
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeQ27642001
Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphateQ27649130
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiaeQ27860755
Global, in vivo, and site-specific phosphorylation dynamics in signaling networksQ27864128
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesisQ27930910
The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) familyQ27934558
Comparison of the rat nucleolar protein nopp140 with its yeast homolog SRP40. Differential phosphorylation in vertebrates and yeast.Q27935798
The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activityQ27937722
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinaseQ28138219
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylationQ28139447
Detection of an appropriate kinase activity in branchial arches I and II that coincides with peak expression of the Treacher Collins syndrome gene product, treacleQ28146134
Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2Q28190925
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphateQ28205958
Osmotic stress-induced remodeling of the cortical cytoskeletonQ28217767
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathwayQ28241789
Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisitedQ28294604
Phospholipid scramblases: an overviewQ28300611
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivoQ28300864
neo-inositol polyphosphates in the amoeba Entamoeba histolyticaQ28375010
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolasesQ28510332
Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3Q28571270
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseQ28571302
The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymesQ28573848
Nopp 140 shuttles on tracks between nucleolus and cytoplasmQ28577621
Molecular cloning of a novel isoform of diphosphoinositol polyphosphate phosphohydrolase: a potential target of lithium therapyQ28581718
Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligandQ28591322
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and deathQ28609905
Telomeres shorten during ageing of human fibroblastsQ29547357
PI3K pathway alterations in cancer: variations on a themeQ29615530
HSP90 and the chaperoning of cancerQ29617504
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomasQ30780305
Phosphatidylinositol phosphate kinase: a link between protein kinase and glutathione synthase foldsQ31388296
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Telomere maintenance by intracellular signals: new kid on the block?Q33838363
Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.Q33966233
Dinucleoside polyphosphates-friend or foe?Q34047296
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.Q34137530
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitroQ34315447
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.Q34402004
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphateQ34454650
How versatile are inositol phosphate kinases?Q34542639
Invited review: Effects of heat and cold stress on mammalian gene expressionQ34564825
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Inositol derivatives: evolution and functionsQ34740418
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysisQ34741451
Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state.Q34848322
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biologyQ35671913
Inositide evolution - towards turtle domination?Q36110299
Inositol pyrophosphates: metabolism and signalingQ36375032
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
14-3-3 proteins: a historic overviewQ36470005
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Inhibitors of the HSP90 molecular chaperone: current statusQ36543819
Proprotein convertases: lessons from knockoutsQ36608875
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunitsQ36699462
Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').Q36711307
The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolinQ36727312
Inositol pyrophosphates get the vip1 treatmentQ36826312
Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes.Q36850372
Inositol polyphosphates: a new frontier for regulating gene expressionQ36974304
An unusual member of the Cdk family: Cdk5.Q37053631
Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2.Q37163350
Human Gene and Protein Database (HGPD): a novel database presenting a large quantity of experiment-based results in human proteomicsQ37202774
Phosphoinositides as regulators of membrane trafficking in health and disease.Q37251853
The heat shock protein 90 chaperone complex: an evolving therapeutic target.Q37264599
The life of a cell: apoptosis regulation by the PI3K/PKB pathwayQ37289433
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donorQ37635615
Casein kinase 2: an 'eminence grise' in cellular regulation?Q37954522
Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.Q38299578
A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathwayQ38353871
Inositol lipids and phosphates in erythrocytes and HL60 cellsQ39582615
The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphatesQ39682295
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.Q39885162
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.Q40251135
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
Diadenosine polyphosphates: Their biological and pharmacological significanceQ40462775
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Q40474530
Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathwayQ40542484
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.Q41455472
The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cellsQ41594669
The inositol phosphates in WRK1 rat mammary tumour cellsQ41810643
The interaction of coatomer with inositol polyphosphates is conserved in Saccharomyces cerevisiaeQ41989824
Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrationsQ42038435
Mutant ras gene induces elevated levels of inositol tris- and hexakisphosphates in DictyosteliumQ42502269
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1).Q42964950
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Diphospho-myo-inositol phosphates from Dictyostelium identified as D-6-diphospho-myo-inositol pentakisphosphate and D-5,6-bisdiphospho-myo-inositol tetrakisphosphateQ42985531
Cyclin-dependent kinase 5 promotes insulin exocytosis.Q43666421
Immunocytochemical localization of prohormone convertase 1/3 and 2 in pancreatic islet cells and islet cell tumorsQ43695153
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 functionQ43809033
Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2Q43913945
Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genesQ44172478
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Accumulation of [3H]-inositol into inositol polyphosphates during development of DictyosteliumQ44610185
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiaeQ46128888
Characterization of the InsP6-dependent interaction between CK2 and Nopp140.Q46368600
Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiaeQ46535287
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroupsQ46771498
Protein kinase CK2 in gene control at cell cycle entryQ46840859
Schizosaccharomyces pombe Aps1, a diadenosine 5',5' "-P1, P6-hexaphosphate hydrolase that is a member of the nudix (MutT) family of hydrolases: cloning of the gene and characterization of the purified enzymeQ47977961
Identification and purification of diphosphoinositol pentakisphosphate kinase, which synthesizes the inositol pyrophosphate bis(diphospho)inositol tetrakisphosphateQ48371551
Determination of free and bound manganese(II) in hepatocytes from fed and fasted ratsQ51650045
Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner.Q53593999
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase ActivityQ57986498
Phosphorylation of nucleolin by a nucleolar type NII protein kinaseQ68532368
Inhibition of Phosphatases and Increased Ca2+ Channel Activity by Inositol HexakisphosphateQ69394850
Numbering of atoms in myo-inositol. Recommendations 1988. Nomenclature Committee of the International Union of BiochemistryQ69973728
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
Hepatic Ins(1,3,4,5)P4 3-phosphatase is compartmentalized inside endoplasmic reticulumQ72959089
Interaction of nucleolin with an evolutionarily conserved pre-ribosomal RNA sequence is required for the assembly of the primary processing complexQ73905828
Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa proteinQ74061173
P433issue24
P304page(s)3851-3871
P577publication date2009-08-28
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleInositol pyrophosphates: structure, enzymology and function
P478volume66

Reverse relations

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