Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules

scientific article published on 28 February 2017

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S41745-016-0011-3
P932PMC publication ID7081659
P698PubMed publication ID32214696

P50authorRashna BhandariQ26000239
P2093author name stringRashna Bhandari
Shubhra Ganguli
Akruti Shah
Jayraj Sen
P2860cites workSynthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processesQ24599387
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activationQ24670467
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neuronsQ24682526
The emerging roles of inositol pyrophosphates in eukaryotic cell physiologyQ26786441
The enzymes of human diphosphoinositol polyphosphate metabolismQ26851038
How inositol pyrophosphates control cellular phosphate homeostasis?Q27016220
Catalytic core of a membrane-associated eukaryotic polyphosphate polymeraseQ27655151
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowdingQ27675827
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug DiscoveryQ27683548
Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride FormationQ27684754
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domainsQ27704571
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiaeQ27930426
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesisQ27930910
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatasesQ27932475
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
Back in the water: the return of the inositol phosphatesQ28186774
Modulation of spectrin-actin assembly by erythrocyte adducinQ28301429
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresisQ28538589
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon responseQ28540195
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseQ28571302
Influence of inositol pyrophosphates on cellular energy dynamics.Q51847806
Inositol pyrophosphates in cell death and life.Q53270297
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.Q54349708
Reversible arrest of haploid yeast cells at the initiation of DNA synthesis by a diffusible sex factorQ69225957
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and PolysphondyliumQ73664304
DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activityQ80208962
An affinity reagent for the recognition of pyrophosphorylated peptidesQ86657216
Signaling phosphate starvationQ41211790
Establishing the stability and reversibility of protein pyrophosphorylation with synthetic peptidesQ41499357
Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L.Q41512865
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesisQ41679412
A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimensQ41767970
Inositol hexakisphosphate kinases induce cell death in Huntington diseaseQ41820993
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signalingQ41830941
Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.Q41846418
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formationQ42325483
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Inositol hexakisphosphate kinases promote autophagy.Q42872768
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.Q43074238
Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiaeQ43143870
Merging high-quality biochemical fractionation with a refined flow cytometry approach to monitor nucleocytoplasmic protein expression throughout the unperturbed mammalian cell cycleQ43416808
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plantsQ44875454
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Inositol pyrophosphates modulate hydrogen peroxide signalling.Q45926680
Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiaeQ46468800
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroupsQ46771498
Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levelsQ46774343
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in ArabidopsisQ48197475
Inositol pyrophosphates: why so many phosphates?Q28652347
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2Q33570316
Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signalingQ33746634
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.Q33966233
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2Q34397020
Identification of a functional nuclear translocation sequence in hPPIP5K2.Q34481151
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell deathQ34526364
Pho85 and signaling environmental conditionsQ34536474
Identification and characterization of Schizosaccharomyces pombe asp1(+), a gene that interacts with mutations in the Arp2/3 complex and actinQ34607183
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Inositol derivatives: evolution and functionsQ34740418
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1Q35090038
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urineQ35318869
Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in celluloQ35913992
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.Q36176216
Cytoplasmic organization in cerebellar dendritic spinesQ36207960
Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activityQ36270671
Synthetic tools for studying the chemical biology of InsP8.Q36276824
Inositol pyrophosphates: metabolism and signalingQ36375032
Diphosphoinositol polyphosphates: what are the mechanisms?Q36426176
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Cytoplasmic dynein participates in the centrosomal localization of the Golgi complexQ36531878
Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiaeQ36543750
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repairQ36579532
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').Q36711307
A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5).Q36727366
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphateQ36835730
Inositol pyrophosphates as mammalian cell signalsQ36886772
Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian CellsQ36898165
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in miceQ37020337
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinaseQ37077554
Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis.Q37126685
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresisQ37186675
The yeast lysosome-like vacuole: endpoint and crossroadsQ37266848
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.Q37340761
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transportQ37394301
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.Q37398176
Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPsQ37416185
Are inositol pyrophosphates signalling molecules?Q37424939
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag releaseQ37482212
Inositol pyrophosphates: structure, enzymology and functionQ37588509
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domainsQ37596231
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domainQ37657049
The signaling role of inositol hexakisphosphate kinases (IP6Ks)Q37805097
Cell signalling by inositol pyrophosphatesQ37989043
Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasisQ38040272
New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic β-cellQ38083452
Inositol pyrophosphates: between signalling and metabolismQ38110945
Functions of inorganic polyphosphates in eukaryotic cells: a coat of many coloursQ38180764
Autophagy at the crossroads of catabolism and anabolismQ38547568
Chemical pyrophosphorylation of functionally diverse peptides.Q38841684
The significance of the 1-kinase/1-phosphatase activities of the PPIP5K familyQ38989731
Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratioQ39678080
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Q40474530
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)23-40
P577publication date2017-02-28
P1433published inJournal of the Indian Institute of ScienceQ15754777
P1476titleInositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
P478volume97