Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

scientific article published on 19 June 2011

Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009988701
P356DOI10.1038/NI.2052
P932PMC publication ID3140608
P698PubMed publication ID21685907
P5875ResearchGate publication ID51231353

P50authorSolomon Halbert SnyderQ1681665
Yonghui JiaQ125338724
P2093author name stringHongbo R Luo
Fabien Loison
Jia Zhong
Subhanjan Mondal
Amit Prasad
Saurabh Ghosh Roy
Yitang Li
Catlyn Blanchard
Anutosh Chakraborty
Jiro Sakai
Supriya K Jain
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Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphateQ27639493
Cell migration: integrating signals from front to backQ27860670
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Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammationQ28508084
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseQ28571302
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functionsQ30479470
Multiple pathways control protein kinase C phosphorylationQ33838086
Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanismQ33888504
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitroQ34315447
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Regulation of PTEN by Rho small GTPasesQ34406790
How versatile are inositol phosphate kinases?Q34542639
Roles of PI3Ks in leukocyte chemotaxis and phagocytosisQ34560905
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Temporal and spatial regulation of chemotaxisQ34984894
Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.Q35075499
Phosphoinositide recognition domainsQ35106866
Chronic granulomatous disease and other disorders of phagocyte functionQ36320268
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide SystemQ37042134
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumoniaQ37201892
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
Are inositol pyrophosphates signalling molecules?Q37424939
Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.Q38299578
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.Q39885162
Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen speciesQ40037121
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophilsQ40325777
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2Q43913945
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidaseQ44283104
Akt Phosphorylates p47phoxand Mediates Respiratory Burst Activity in Human NeutrophilsQ44432151
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophilsQ44857079
Inhibition of human neutrophil IL-8 production by hydrogen peroxide and dysregulation in chronic granulomatous diseaseQ45195941
PI(3)Kγ has an important context-dependent role in neutrophil chemokinesisQ57006266
Leukocyte PI3K and PI3K have temporally distinct roles for leukocyte recruitment in vivoQ57184618
Chronic granulomatous diseaseQ67488183
Difference in hydrogen peroxide release between human neutrophils and neutrophil cytoplasts following calcium ionophore activation. A role of the subcellular granule in activation of the NADPH-oxidase in human neutrophils?Q69323991
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
G protein signaling events are activated at the leading edge of chemotactic cellsQ77431001
Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cellsQ78863090
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)752-760
P577publication date2011-06-19
P1433published inNature ImmunologyQ1071725
P1476titleInositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
P478volume12

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cites work (P2860)
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