The emerging roles of inositol pyrophosphates in eukaryotic cell physiology

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The emerging roles of inositol pyrophosphates in eukaryotic cell physiology is …
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P6179Dimensions Publication ID1052306073
P356DOI10.1007/S12038-015-9549-X
P3181OpenCitations bibliographic resource ID1982463
P698PubMed publication ID26333405

P50authorRashna BhandariQ26000239
P2093author name stringSwarna Gowri Thota
P2860cites workThe interaction of coatomer with inositol polyphosphates is conserved in Saccharomyces cerevisiaeQ41989824
Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrationsQ42038435
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formationQ42325483
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2+-sensitivity, purification and antibody productionQ42794241
Inositol hexakisphosphate kinases promote autophagy.Q42872768
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.Q43074238
Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiaeQ43143870
Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2Q43913945
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.Q41455472
Establishing the stability and reversibility of protein pyrophosphorylation with synthetic peptidesQ41499357
Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L.Q41512865
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signalingQ41830941
Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C.Q41858547
Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo-inositol tetrakisphosphate from Dictyostelium resolved by NMR analysisQ41982271
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plantsQ44875454
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Inositol pyrophosphates modulate hydrogen peroxide signalling.Q45926680
Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiaeQ46128888
Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiaeQ46468800
Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levelsQ46774343
Purification and characterization of two types of soluble inositol phosphate 5-phosphomonoesterases from rat brainQ48170093
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in ArabidopsisQ48197475
Influence of inositol pyrophosphates on cellular energy dynamics.Q51847806
Phosphorylated derivatives of myo-inositol.Q52489794
Inositol pyrophosphates in cell death and life.Q53270297
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.Q54349708
Nomenclature Committee of the International Union of Biochemistry (NC-IUB). Numbering of atoms in myo-inositol. Recommendations 1988Q69598712
Numbering of atoms in myo-inositol. Recommendations 1988. Nomenclature Committee of the International Union of BiochemistryQ69973728
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigationQ79256314
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificityQ79271161
Extraction and analysis of soluble inositol polyphosphates from yeastQ80093282
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type proteinQ22010421
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt familyQ22253958
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinaseQ24300393
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinaseQ24311755
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzymeQ24319980
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cellsQ24530557
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processesQ24599387
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
The enzymes of human diphosphoinositol polyphosphate metabolismQ26851038
Structural insight into inositol pyrophosphate turnoverQ27011244
How inositol pyrophosphates control cellular phosphate homeostasis?Q27016220
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungiQ27313776
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowdingQ27675827
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug DiscoveryQ27683548
IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase familyQ27684442
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiaeQ27930426
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesisQ27930910
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activityQ27930927
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatasesQ27932475
Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiaeQ27936464
Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiaeQ27936942
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional controlQ27937822
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA exportQ27938472
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
Back in the water: the return of the inositol phosphatesQ28186774
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinaseQ28280529
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinaseQ28280540
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresisQ28538589
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon responseQ28540195
Inositol pyrophosphates: why so many phosphates?Q28652347
Turtles All the Way: Reflections on myo-InositolQ28750854
Calcium signalling: dynamics, homeostasis and remodellingQ29547635
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2Q33570316
Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signalingQ33746634
Assessing the omnipotence of inositol hexakisphosphateQ33940944
Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.Q33966233
Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domainQ34077876
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
The pathway for the production of inositol hexakisphosphate in human cellsQ34365911
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2Q34397020
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell deathQ34526364
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1Q35090038
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urineQ35318869
The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growthQ36132888
Inositol pyrophosphates: metabolism and signalingQ36375032
Diphosphoinositol polyphosphates: what are the mechanisms?Q36426176
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
Live cell imaging of phosphoinositide dynamics with fluorescent protein domainsQ36479477
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiaeQ36543750
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repairQ36579532
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').Q36711307
Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes.Q36850372
Inositol pyrophosphates as mammalian cell signalsQ36886772
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinaseQ37077554
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
The Krebs cycle meets the cell cycle: mitochondria and the G1-S transitionQ37274443
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.Q37340761
Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPsQ37416185
Are inositol pyrophosphates signalling molecules?Q37424939
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag releaseQ37482212
Inositol pyrophosphates: structure, enzymology and functionQ37588509
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domainsQ37596231
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donorQ37635615
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domainQ37657049
The signaling role of inositol hexakisphosphate kinases (IP6Ks)Q37805097
Cell signalling by inositol pyrophosphatesQ37989043
Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasisQ38040272
New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic β-cellQ38083452
Inositol pyrophosphates: between signalling and metabolismQ38110945
The physiological roles of primary phospholipase C.Q38138205
Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.Q38299578
Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratioQ39678080
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphysiologyQ521
P304page(s)593-605
P577publication date2015-09-01
P1433published inJournal of BiosciencesQ2092222
P1476titleThe emerging roles of inositol pyrophosphates in eukaryotic cell physiology
P478volume40

Reverse relations

cites work (P2860)
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Q47250401The inositol pyrophosphate pathway in health and diseases
Q57145863Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors

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