Inositol pyrophosphates as mammalian cell signals

scientific article published on 23 August 2011

Inositol pyrophosphates as mammalian cell signals is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.2001958
P932PMC publication ID3667551
P698PubMed publication ID21878680
P5875ResearchGate publication ID51606478

P50authorSolomon Halbert SnyderQ1681665
P2093author name stringSeyun Kim
Anutosh Chakraborty
P2860cites workSynthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Inhibition of adipogenesis by Wnt signalingQ22254771
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
A CK2-dependent mechanism for degradation of the PML tumor suppressorQ24298158
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinaseQ24300393
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphateQ41687573
The inositol phosphates in WRK1 rat mammary tumour cellsQ41810643
Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykininQ41816200
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signalingQ41830941
Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo-inositol tetrakisphosphate from Dictyostelium resolved by NMR analysisQ41982271
Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrationsQ42038435
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
A scalable synthesis of the IP7 isomer, 5-PP-Ins(1,2,3,4,6)P5.Q42161635
Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombeQ42428295
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanismsQ42799849
Inositol hexakisphosphate kinases promote autophagy.Q42872768
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Accumulation of [3H]-inositol into inositol polyphosphates during development of DictyosteliumQ44610185
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophreniaQ44743796
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Inositol pyrophosphates modulate hydrogen peroxide signalling.Q45926680
Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiaeQ46535287
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroupsQ46771498
Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscleQ46818437
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.Q54034599
Pleckstrin homology domain as an inositol compound binding module.Q55067522
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase ActivityQ57986498
Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cellsQ69785920
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacityQ71825216
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and PolysphondyliumQ73664304
Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa proteinQ74061173
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigationQ79256314
Positive regulation of Itk PH domain function by soluble IP4Q80108134
An inositol 1,4,5-trisphosphate-6-kinase activity in pea rootsQ86623685
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
A beta-arrestin 2 signaling complex mediates lithium action on behaviorQ24306355
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cellsQ24530557
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
AKT/PKB signaling: navigating downstreamQ24657857
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
A transforming mutation in the pleckstrin homology domain of AKT1 in cancerQ27646556
The Wnt signaling pathway in development and diseaseQ27861019
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesisQ27930910
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activityQ27930927
ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginineQ27932184
Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiaeQ27936942
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional controlQ27937822
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their productsQ27939318
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinaseQ28138219
Back in the water: the return of the inositol phosphatesQ28186774
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinasesQ28201486
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphateQ28205958
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathwayQ28241789
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in YeastQ28277565
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORsQ28286431
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissuesQ28287222
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivoQ28300864
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger productionQ28513065
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseQ28571302
The versatility and universality of calcium signallingQ29547402
Membrane recognition by phospholipid-binding domainsQ29614848
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Chemokines and chemokine receptors in leukocyte traffickingQ30309533
Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathwayQ30497487
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivoQ33281051
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphateQ33620076
Phosphoinositide binding domains: embracing 3-phosphateQ33684004
Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactionsQ33817574
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesisQ33896013
Involvement of protein kinase CK2 in angiogenesis and retinal neovascularizationQ34049304
Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR.Q34178755
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2Q34397020
Inositol polyphosphates are not increased by overexpression of Ins(1,4,5)P3 3-kinase but show cell-cycle dependent changes in growth factor-stimulated fibroblastsQ34439606
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.Q34533714
How versatile are inositol phosphate kinases?Q34542639
Roles of PI3Ks in leukocyte chemotaxis and phagocytosisQ34560905
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.Q34573044
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
TRAIL receptor signalling and modulation: Are we on the right TRAIL?Q34913133
The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetesQ34974764
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomesQ35216433
Inositol phosphate biochemistryQ35231371
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.Q35965439
Inositol pyrophosphates: metabolism and signalingQ36375032
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
The role of PI3Ks in the regulation of the neutrophil NADPH oxidaseQ36711248
Inositol polyphosphates: a new frontier for regulating gene expressionQ36974304
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinaseQ37077554
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresisQ37186675
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag releaseQ37482212
Addiction to protein kinase CK2: a common denominator of diverse cancer cells?Q37576535
Inositol pyrophosphates: structure, enzymology and functionQ37588509
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donorQ37635615
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domainQ37657049
Protein phosphorylation in bacterial signal transductionQ37832311
Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3.Q38299578
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese miceQ39280475
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinaseQ39599480
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.Q39885162
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Inositol pentakisphosphate mediates Wnt/beta-catenin signalingQ40114861
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.Q40251135
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophilsQ40325777
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Q40474530
Protocols for regulation and study of diphosphoinositol polyphosphates.Q40519725
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cellsQ41594669
P433issue188
P304page(s)re1
P577publication date2011-08-23
P1433published inScience SignalingQ7433604
P1476titleInositol pyrophosphates as mammalian cell signals
P478volume4

Reverse relations

cites work (P2860)
Q35318869A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine
Q92573512A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
Q24322033Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor
Q41679412Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis
Q36270671Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity
Q28078208Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
Q41549123Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.
Q38841684Chemical pyrophosphorylation of functionally diverse peptides.
Q38837404Chemical tools for interrogating inositol pyrophosphate structure and function.
Q36835730Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate
Q36263837Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.
Q37020337Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice
Q47944803Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
Q42828086Differential response of MC3T3-E1 and human mesenchymal stem cells to inositol hexakisphosphate
Q41499357Establishing the stability and reversibility of protein pyrophosphorylation with synthetic peptides
Q38433610Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain
Q28540195Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response
Q35946323Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase
Q38430822IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Q90630104Identification of the Antidepressant Vilazodone asan Inhibitor of Inositol Polyphosphate Multikinaseby Structure-Based Drug Repositioning
Q64947264Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.
Q48149189Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery
Q91600423Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses
Q59604012Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
Q34384846Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts
Q52664251Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Q38437282Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis
Q34526364Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death
Q44273064Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways
Q38405047Inositol phosphate multikinase dependent transcriptional control
Q37737248Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism
Q64904944Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Q33590960Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Q36403568Inositol polyphosphate multikinase signaling in the regulation of metabolism
Q35925870Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase
Q37398176Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.
Q36579532Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair
Q37126685Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis.
Q33570316Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2
Q35090038Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
Q37340761Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Q43143870Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae
Q41512865Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L.
Q34305020Obesity and cancer risk: evidence, mechanisms, and recommendations
Q37596231PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains
Q62031721Phospholipids and inositol phosphates linked to the epigenome
Q54339361Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling.
Q47637691Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
Q35641269Quantification of myo-inositol, 1,5-anhydro- D-sorbitol, and D-chiro-inositol using high-performance liquid chromatography with electrochemical detection in very small volume clinical samples
Q39450085Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein
Q38009859Resolving the kinetics of lipid, protein and peptide diffusion in membranes
Q88427753Role of inositol polyphosphates in programed cell death in Dictyostelium discoideum and its developmental life cycle
Q91458078Role of phosphate sensing in bone and mineral metabolism
Q27011244Structural insight into inositol pyrophosphate turnover
Q43074238Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.
Q38796988Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.
Q36276824Synthetic tools for studying the chemical biology of InsP8.
Q37315258Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans
Q38435784TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Q38051736Targeting class I histone deacetylases in cancer therapy
Q90597925Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Q37502964The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).
Q33775102The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub.
Q26786441The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
Q26851038The enzymes of human diphosphoinositol polyphosphate metabolism
Q47250401The inositol pyrophosphate pathway in health and diseases
Q34317637The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
Q36853305The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade
Q48197475VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis
Q45538704When worlds collide: inositol pyrophosphates and phosphoinositides intersect at the plasma membrane

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