Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation

scientific article

Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M700156200
P932PMC publication ID2048714
P698PubMed publication ID17379600

P2093author name stringZhuo Tang
Joseph A Bauer
Joseph A DiDonato
Daniel J Lindner
Bei H Morrison
Heidi Schmidt
Joseph A Lupica
P2860cites workInositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBQ24321775
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNFQ24550953
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2Q24642851
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sitesQ24673550
Structural basis for self-association and receptor recognition of human TRAF2Q27617947
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90Q28203709
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell deathQ28209948
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrateQ28280916
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivoQ28504462
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activationQ28584897
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and deathQ28609905
Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repairQ28646559
New colorimetric cytotoxicity assay for anticancer-drug screeningQ29615418
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
The Toll-receptor family and control of innate immunityQ33536547
Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobilityQ34333584
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cellsQ39613693
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinomaQ40235625
Assaying for I kappa B kinase activityQ41750787
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cellsQ42466765
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound SubstrateQ55919356
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activationQ73745042
TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survivalQ73925277
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
NF-κBQ411114
P304page(s)15349-56
P577publication date2007-05-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleEffect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation
P478volume282

Reverse relations

cites work (P2860)
Q34573044Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.
Q38837404Chemical tools for interrogating inositol pyrophosphate structure and function.
Q37268113Diphosphoinositol polyphosphates: metabolic messengers?
Q33758332Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats
Q36446083HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
Q36446267IP6K2 is a client for HSP90 and a target for cancer therapeutics development
Q45911936In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.
Q59604012Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
Q37588509Inositol pyrophosphates: structure, enzymology and function
Q26851038The enzymes of human diphosphoinositol polyphosphate metabolism
Q47250401The inositol pyrophosphate pathway in health and diseases
Q37805097The signaling role of inositol hexakisphosphate kinases (IP6Ks)

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