| scholarly article | Q13442814 |
| P50 | author | André Kleinridders | Q55164881 |
| José Pedro Castro | Q92616183 | ||
| Tilman Grune | Q42577412 | ||
| P2093 | author name string | Kristina Wardelmann | |
| P2860 | cites work | Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases | Q22241397 |
| Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis | Q24293446 | ||
| Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly | Q24299292 | ||
| Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance | Q24299552 | ||
| The role of oxidative stress in Parkinson's disease | Q24307946 | ||
| Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy | Q24311582 | ||
| Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit | Q24337773 | ||
| Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis | Q24337960 | ||
| Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70 | Q24338681 | ||
| Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60 | Q24563811 | ||
| A hitchhiker's guide to the human Hsp70 family | Q24597572 | ||
| Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling | Q24608960 | ||
| Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival | Q24629776 | ||
| SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress | Q24670578 | ||
| Metabolic regulation of mitochondrial dynamics | Q26768130 | ||
| Insulin receptor signaling in normal and insulin-resistant states | Q26823171 | ||
| Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain | Q27646892 | ||
| Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria | Q27933539 | ||
| Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. | Q27933616 | ||
| The molecular chaperone Hsp78 confers compartment-specific thermotolerance to mitochondria | Q27937401 | ||
| Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria | Q27938263 | ||
| Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding | Q27939869 | ||
| Protein disaggregation mediated by heat-shock protein Hsp104. | Q27940314 | ||
| Dysregulation of autophagy and mitochondrial function in Parkinson's disease | Q28071890 | ||
| Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice | Q28208193 | ||
| Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity | Q28394667 | ||
| Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus | Q28397425 | ||
| Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice | Q28507648 | ||
| Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease | Q37151436 | ||
| Oxidative stress and insulin resistance: the coronary artery risk development in young adults study. | Q37235949 | ||
| Leptin regulation of Hsp60 impacts hypothalamic insulin signaling | Q37259229 | ||
| Effects of a Mutation in the HSPE1 Gene Encoding the Mitochondrial Co-chaperonin HSP10 and Its Potential Association with a Neurological and Developmental Disorder. | Q37318048 | ||
| Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. | Q37339111 | ||
| Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants | Q37352307 | ||
| Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study | Q37529582 | ||
| Mitochondrial dynamics in mammalian health and disease | Q37543838 | ||
| Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease | Q37557789 | ||
| Mitochondria in Huntington's disease | Q37580111 | ||
| Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence | Q37581663 | ||
| Somatic mitochondrial DNA mutations in mammalian aging | Q37720726 | ||
| Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1. | Q37726096 | ||
| Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation. | Q37762513 | ||
| The mitochondrial UPR - protecting organelle protein homeostasis | Q37806885 | ||
| Mitochondrial protein quality control during biogenesis and aging | Q37847411 | ||
| Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases? | Q37880356 | ||
| Quality control of mitochondrial proteostasis | Q37882863 | ||
| TRAP-1, the mitochondrial Hsp90. | Q37924023 | ||
| Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation | Q37966074 | ||
| Cellular Links between Neuronal Activity and Energy Homeostasis | Q37999314 | ||
| Shared dysregulated pathways lead to Parkinson's disease and diabetes | Q38078667 | ||
| The brain modulates insulin sensitivity in multiple tissues | Q38204663 | ||
| Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease | Q38372209 | ||
| Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. | Q38747462 | ||
| A Mutation in the Flavin Adenine Dinucleotide-Dependent Oxidoreductase FOXRED1 Results in Cell-Type-Specific Assembly Defects in Oxidative Phosphorylation Complexes I and II. | Q38769102 | ||
| A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome | Q38816704 | ||
| Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. | Q38818474 | ||
| Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action | Q38849153 | ||
| Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action | Q38920715 | ||
| Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment. | Q39016389 | ||
| Cellular Regulation of Amyloid Formation in Aging and Disease | Q39162492 | ||
| Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. | Q39251334 | ||
| Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival | Q39401287 | ||
| Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment | Q39472298 | ||
| Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons | Q39695680 | ||
| Hsp78 chaperone functions in restoration of mitochondrial network following heat stress. | Q50736251 | ||
| Protein Misfolding Diseases. | Q51036364 | ||
| CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. | Q51758932 | ||
| Chaperoning extended life. | Q52559924 | ||
| Type 2 diabetes and the risk of Parkinson's disease. | Q53016612 | ||
| Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis | Q57073746 | ||
| Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease | Q64763346 | ||
| Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome | Q71513482 | ||
| Familial longevity is marked by enhanced insulin sensitivity | Q39818313 | ||
| Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). | Q39996799 | ||
| Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes | Q40166169 | ||
| Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis | Q40248003 | ||
| Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease | Q40607421 | ||
| The relationship between diabetes mellitus and Parkinson's disease | Q40701172 | ||
| Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. | Q40751982 | ||
| ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells | Q40768669 | ||
| Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells | Q40799740 | ||
| Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway | Q41050313 | ||
| Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice | Q41206122 | ||
| Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain. | Q41232824 | ||
| An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications | Q41702999 | ||
| A computational model of motor neuron degeneration | Q41826395 | ||
| Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. | Q41892915 | ||
| Mitochondrial contribution to lipofuscin formation. | Q42042230 | ||
| Brain mitochondrial dysfunction in aging, neurodegeneration and Parkinson's disease | Q42176073 | ||
| Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin | Q43223701 | ||
| Hypothalamic insulin signaling is required for inhibition of glucose production | Q44212603 | ||
| Increased risk of type 2 diabetes in Alzheimer disease | Q44745172 | ||
| Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response | Q46131495 | ||
| Higher levels of heat shock proteins in longer-lived mammals and birds | Q46193463 | ||
| SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats | Q46321209 | ||
| Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance | Q46379414 | ||
| Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones | Q47069260 | ||
| Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models | Q47160614 | ||
| Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease | Q47169769 | ||
| Role of brain insulin receptor in control of body weight and reproduction | Q47229086 | ||
| Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance | Q47431942 | ||
| Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture | Q47449361 | ||
| Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients | Q47771671 | ||
| Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice | Q47932196 | ||
| The association between insulin resistance and depression in the Korean general population | Q48037132 | ||
| Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease. | Q48747176 | ||
| Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring | Q50088049 | ||
| Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. | Q50115832 | ||
| Exercise training and experimental diabetes modulate heat shock protein response in brain | Q28583889 | ||
| Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development | Q28587981 | ||
| Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase | Q28910461 | ||
| A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine | Q29547303 | ||
| Mitochondrial formation of reactive oxygen species | Q29547906 | ||
| HSP90 at the hub of protein homeostasis: emerging mechanistic insights | Q29616824 | ||
| Molecular chaperones and protein quality control | Q29617795 | ||
| Mitochondrial dysfunction and type 2 diabetes | Q29617913 | ||
| Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators | Q29618401 | ||
| High frequency of mitochondrial complex I mutations in Parkinson's disease and aging | Q30434711 | ||
| Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. | Q30440422 | ||
| Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins | Q30503728 | ||
| Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. | Q30631520 | ||
| Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. | Q31048734 | ||
| The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response | Q33298588 | ||
| Hsp90 inhibition decreases mitochondrial protein turnover | Q33303676 | ||
| Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease | Q33602136 | ||
| The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria | Q33638683 | ||
| European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). | Q33761211 | ||
| Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism | Q33778499 | ||
| Insulin action in brain regulates systemic metabolism and brain function | Q33789365 | ||
| The impact of dietary energy intake on cognitive aging | Q33868403 | ||
| Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency. | Q33921000 | ||
| Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. | Q33953141 | ||
| Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks | Q34022075 | ||
| Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity | Q34080716 | ||
| A mitochondrial specific stress response in mammalian cells | Q34090940 | ||
| ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation | Q34122622 | ||
| An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. | Q34123789 | ||
| The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity | Q34154475 | ||
| Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity | Q34344644 | ||
| Molecular chaperone functions in protein folding and proteostasis | Q34349321 | ||
| Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons | Q34383447 | ||
| Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity | Q34402031 | ||
| Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration | Q34451639 | ||
| CLPB mutations cause 3-methylglutaconic aciduria, progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder | Q34458607 | ||
| CLPB variants associated with autosomal-recessive mitochondrial disorder with cataract, neutropenia, epilepsy, and methylglutaconic aciduria | Q34458614 | ||
| The biology of proteostasis in aging and disease | Q34467650 | ||
| TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression | Q34532535 | ||
| Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import | Q34565583 | ||
| Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels | Q34614572 | ||
| Ageing and diabetes: implications for brain function | Q34635793 | ||
| Oxidative stress and the etiology of insulin resistance and type 2 diabetes | Q34768229 | ||
| Diabetes and the risk of developing Parkinson's disease in Denmark. | Q35043736 | ||
| Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells | Q35220373 | ||
| Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria. | Q35544534 | ||
| Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice | Q35561118 | ||
| The small Tim proteins and the twin Cx3C motif | Q35632006 | ||
| Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease | Q35758632 | ||
| Type 2 diabetes as a protein misfolding disease. | Q35822682 | ||
| Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities | Q35902875 | ||
| The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures | Q36174913 | ||
| Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons | Q36194343 | ||
| Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration | Q36384373 | ||
| SIRT3 functions in the nucleus in the control of stress-related gene expression | Q36435193 | ||
| Quality control of mitochondria: protection against neurodegeneration and ageing | Q36446844 | ||
| Glial cell inhibition of neurons by release of ATP | Q36569710 | ||
| Oxidative stress, insulin signaling, and diabetes. | Q36570342 | ||
| Central insulin action regulates peripheral glucose and fat metabolism in mice | Q36597490 | ||
| The mTOR pathway in the control of protein synthesis | Q36600753 | ||
| Hippocampal hypometabolism predicts cognitive decline from normal aging | Q36725261 | ||
| Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy | Q36744667 | ||
| Role for neuronal insulin resistance in neurodegenerative diseases | Q36853917 | ||
| Mitonuclear protein imbalance as a conserved longevity mechanism | Q36873369 | ||
| Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response | Q36917773 | ||
| TRAP1 rescues PINK1 loss-of-function phenotypes | Q36950677 | ||
| Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). | Q36956834 | ||
| Brain mitochondrial dysfunction in aging | Q37141862 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | molecular chaperones | Q422496 |
| P304 | page(s) | 196 | |
| P577 | publication date | 2018-04-26 | |
| P1433 | published in | Frontiers in Endocrinology | Q27723680 |
| P1476 | title | Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism? | |
| P478 | volume | 9 |
| Q90632658 | Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases |
| Q64246566 | Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain |
| Q100533628 | Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids |
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