| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.CMET.2006.04.008 |
| P8608 | Fatcat ID | release_xk3onlnl6zfptbfyk73cajgdma |
| P3181 | OpenCitations bibliographic resource ID | 404262 |
| P698 | PubMed publication ID | 16814735 |
| P5875 | ResearchGate publication ID | 6969557 |
| P50 | author | Juleen Zierath | Q4990943 |
| Heikki A. Koistinen | Q37634887 | ||
| Anna Krook | Q47235940 | ||
| P2093 | author name string | Bei B Zhang | |
| Karim Bouzakri | |||
| Lubna Al-Khalili | |||
| Anna Zachrisson | |||
| P2860 | cites work | A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain | Q22009089 |
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| A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family | Q24323752 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis | Q24669916 | ||
| Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Q27860926 | ||
| Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein | Q28116980 | ||
| The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus | Q28190307 | ||
| Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients | Q28363309 | ||
| Role for Akt3/protein kinase Bgamma in attainment of normal brain size | Q28509294 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy | Q29619282 | ||
| Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. | Q30875462 | ||
| Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism | Q33830715 | ||
| Insulin action and insulin resistance in human skeletal muscle | Q34010649 | ||
| Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation | Q34183649 | ||
| Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle | Q34433101 | ||
| Role of Akt/protein kinase B in metabolism. | Q34997136 | ||
| Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing | Q35146125 | ||
| FoxOs at the crossroads of cellular metabolism, differentiation, and transformation | Q35770614 | ||
| Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues | Q36011805 | ||
| Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners | Q36252775 | ||
| From mice to men: insights into the insulin resistance syndromes | Q36387884 | ||
| Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160. | Q37537923 | ||
| Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin | Q38326247 | ||
| Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. | Q40447329 | ||
| The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors | Q40559475 | ||
| Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes | Q42441787 | ||
| WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients | Q42465743 | ||
| Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation | Q42529125 | ||
| Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro | Q42825221 | ||
| Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin | Q42829524 | ||
| Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice | Q43726502 | ||
| A cellular model system of differentiated human myotubes | Q43921005 | ||
| Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects | Q44192210 | ||
| Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance | Q44381191 | ||
| RNA interference-mediated reduction in GLUT1 inhibits serum-induced glucose transport in primary human skeletal muscle cells | Q44505853 | ||
| Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes | Q44792800 | ||
| ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle | Q46239218 | ||
| A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. | Q47904052 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients | Q58449883 | ||
| Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade | Q77795070 | ||
| Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle | Q78010382 | ||
| WY-14643 and 9-cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients | Q95812088 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glucose | Q37525 |
| Insulin receptor substrate 1 | Q1665322 | ||
| gene silencing | Q1431332 | ||
| lipid homeostasis | Q14878190 | ||
| AKT serine/threonine kinase 1 | Q21114990 | ||
| AKT serine/threonine kinase 2 | Q21116502 | ||
| Insulin receptor substrate 2 | Q21173765 | ||
| P304 | page(s) | 89-96 | |
| P577 | publication date | 2006-07-01 | |
| P1433 | published in | Cell Metabolism | Q1254684 |
| P1476 | title | siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle | |
| P478 | volume | 4 |
| Q33634631 | 2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls |
| Q50527602 | A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation |
| Q38877389 | A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk |
| Q47590663 | A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study |
| Q34914262 | A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice |
| Q36628896 | AMPK and Exercise: Glucose Uptake and Insulin Sensitivity. |
| Q21142682 | Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells |
| Q44609387 | Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle |
| Q37174195 | Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation |
| Q33384632 | Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight |
| Q37337564 | Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice |
| Q24311740 | Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2) |
| Q34718673 | Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle |
| Q37168778 | Biomarkers of response to Akt inhibitor MK-2206 in breast cancer |
| Q36699832 | Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats |
| Q37558689 | Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules |
| Q88064814 | Curcumin and dietary polyphenol research: beyond drug discovery |
| Q35325626 | Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors |
| Q37636194 | Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy |
| Q92051220 | Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination |
| Q37249009 | Developmental programming in skeletal muscle in response to overnourishment in the immediate postnatal life in rats |
| Q43050403 | Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action. |
| Q33614014 | Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. |
| Q37361165 | Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation |
| Q51762152 | Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. |
| Q37795116 | Docking proteins. |
| Q42103189 | Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro |
| Q58172078 | Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle |
| Q37249333 | Exercise-induced phospho-proteins in skeletal muscle. |
| Q38828030 | Expression Change of miR-214 and miR-135 during Muscle Differentiation. |
| Q38003638 | From signal transduction to signal interpretation: an alternative model for the molecular function of insulin receptor substrates. |
| Q33837547 | Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome |
| Q37718885 | Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities |
| Q38322298 | Genetic downregulation of receptor-interacting protein 140 uncovers the central role of Akt signalling in the regulation of fatty acid oxidation in skeletal muscle cells |
| Q46491807 | Globular adiponectin stimulates glucose transport in type 2 diabetic muscle |
| Q42449550 | Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 beta hydroxysteroid dehydrogenase type 1 in human skeletal muscle |
| Q38507568 | Glucose transporters: cellular links to hyperglycemia in insulin resistance and diabetes. |
| Q34777521 | High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine |
| Q36990467 | High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism |
| Q37193376 | Impairments in site-specific AS160 phosphorylation and effects of exercise training. |
| Q57545107 | Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training |
| Q39565163 | Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. |
| Q37163482 | Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle |
| Q26823171 | Insulin receptor signaling in normal and insulin-resistant states |
| Q37264729 | Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells |
| Q27334898 | Insulin signaling regulates fatty acid catabolism at the level of CoA activation |
| Q37501407 | Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle |
| Q54631286 | Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907 |
| Q37345367 | Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes |
| Q46801587 | Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients |
| Q93264363 | Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis |
| Q55042948 | MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. |
| Q36751833 | Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q37535443 | MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway |
| Q38951353 | MicroRNA-181b suppresses TAG via target IRS2 and regulating multiple genes in the Hippo pathway |
| Q34750679 | MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease |
| Q60950122 | MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes |
| Q21131281 | Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances |
| Q37776761 | Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies |
| Q51831535 | NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors. |
| Q28550274 | Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts |
| Q89761326 | PRL/microRNA-183/IRS1 Pathway Regulates Milk Fat Metabolism in Cow Mammary Epithelial Cells |
| Q50297799 | Phosphorylation of IRS |
| Q24315127 | Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells |
| Q33589341 | Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation. |
| Q47148579 | Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out. |
| Q46135106 | Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle |
| Q36943315 | Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis |
| Q35599870 | Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis |
| Q41955962 | Role and potential mechanisms of anabolic resistance in sarcopenia |
| Q42247586 | Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription |
| Q36825642 | Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport. |
| Q24310873 | Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells |
| Q38795242 | Roux-en-Y gastric bypass surgery enhances contraction-mediated glucose metabolism in primary human myotubes. |
| Q48002642 | SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK. |
| Q36842339 | Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. |
| Q42488988 | Serum starvation: caveat emptor |
| Q52921010 | Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. |
| Q37427465 | Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA. |
| Q30758631 | Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin |
| Q42361197 | Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice |
| Q37549798 | The Akt kinases: isoform specificity in metabolism and cancer |
| Q33643340 | The GLUT4 code |
| Q91669779 | The Lymphatic System in Obesity, Insulin Resistance, and Cardiovascular Diseases |
| Q30494570 | The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration |
| Q24295143 | The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation |
| Q47656590 | The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells |
| Q37060991 | The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| Q54979184 | The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes. |
| Q93147070 | Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review |
| Q37638216 | mTOR function in skeletal muscle: a focal point for overnutrition and exercise |
| Q36807616 | siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle |
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