Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

scientific article published on 21 November 2018

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCSM.12336
P932PMC publication ID6438346
P698PubMed publication ID30461220

P50authorYann-Gaël GangloffQ56452314
E GoillotQ70150428
Agnès DuplanyQ82038373
Laetitia MazelinQ84891671
P2093author name stringQing Zhang
Jie Chen
Laurent Schaeffer
Nathalie Streichenberger
Shuzhe Ding
Karine Gauthier
Vincent Moncollin
Sandrine Mouradian
Céline Angleraux
P2860cites worksiRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscleQ24295160
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specificationQ28574258
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activityQ30442556
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A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous miceQ33449060
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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathyQ33589972
Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane associationQ33642606
Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissuesQ33685319
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.Q33773474
Satellite cells and the muscle stem cell nicheQ33816665
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processingQ33903835
Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.Q34060841
Myogenic satellite cells: physiology to molecular biologyQ34084128
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocationQ34183649
Protein kinase B (PKB/Akt)--a key regulator of glucose transport?Q34189344
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathyQ34340407
Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease.Q34639597
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficQ34778453
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophyQ34891582
Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).Q35371402
Perilipin 5-Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21Q35881713
A unifying model for mTORC1-mediated regulation of mRNA translation.Q35945036
Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesityQ36040443
Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscleQ36211023
Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle.Q36323505
Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophyQ36379979
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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.Q36497296
Whole body and skeletal muscle protein turnover in recovery from burns.Q36576536
The underappreciated role of muscle in health and diseaseQ36588837
TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular DystrophyQ36590389
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac functionQ36646353
mTOR signaling and the molecular adaptation to resistance exercise.Q36649624
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolismQ36709204
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.Q36755594
Impaired Mitochondrial Fat Oxidation Induces FGF21 in MuscleQ36936246
FGF21 is an Akt-regulated myokineQ37017459
Abnormal growth in mitochondrial diseaseQ37361327
mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanismsQ37474514
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophyQ37574344
FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disordersQ37610032
Mechanisms regulating skeletal muscle growth and atrophyQ38091731
mTOR signaling in cellular and organismal energeticsQ38305897
mTOR: a pharmacologic target for autophagy regulationQ38345168
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokineQ39042458
Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activationQ39095069
Considerations on mTOR regulation at serine 2448: implications for muscle metabolism studies.Q39144817
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese miceQ39280475
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.Q40456155
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibitionQ42452282
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.Q42500373
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.Q42995176
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cellsQ46466470
Differential glucose metabolism in mice and humans affected by McArdle disease.Q46535269
Differential Muscle Involvement in Mice and Humans Affected by McArdle Disease.Q46571361
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetesQ46626385
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mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.Q47999496
Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.Q48090067
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mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4.Q50142087
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.Q50578906
mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.Q53110486
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.Q53438320
mTOR Signaling in Growth, Metabolism, and Disease.Q54144950
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.Q54398394
Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capabilityQ57600775
Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.Q64881548
Age-related differences in absolute numbers of skeletal muscle satellite cellsQ71111509
Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expressionQ79188519
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animalsQ80804178
The role of skeletal muscle mTOR in the regulation of mechanical load-induced growthQ84984851
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)35-53
P577publication date2018-11-21
P1433published inJournal of Cachexia, Sarcopenia and MuscleQ6294897
P1476titleLack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis
P478volume10

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Q92816070Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activitycites workP2860

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