| P50 | author | Cullen M. Taniguchi | Q58667910 |
| | Kohjiro Ueki | Q65013004 |
| P2093 | author name string | Ronald Kahn | |
| P2860 | cites work | Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 |
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| | CRE recombinase-inducible RNA interference mediated by lentiviral vectors | Q24562287 |
| | Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse | Q24564225 |
| | Cre-lox-regulated conditional RNA interference from transgenes | Q24564248 |
| | RNA interference | Q28131798 |
| | Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice | Q28144106 |
| | Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase | Q28508079 |
| | Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms | Q28586863 |
| | Rational siRNA design for RNA interference | Q29614450 |
| | A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference | Q29615920 |
| | A DNA vector-based RNAi technology to suppress gene expression in mammalian cells | Q29616551 |
| | Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways | Q29618467 |
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| | Control of siRNA expression using the Cre-loxP recombination system. | Q33833394 |
| | Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. | Q52541535 |
| | Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. | Q54150649 |
| | Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction | Q61203351 |
| | Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles | Q73085036 |
| | Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells | Q73316496 |
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| | Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction | Q74191142 |
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| | Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes | Q36698641 |
| | Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle | Q37175187 |
| | Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse | Q37376749 |
| | Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. | Q37388544 |
| | Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver | Q38297185 |
| | Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver | Q39740783 |
| | Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production | Q39741170 |
| | Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice | Q40019067 |
| | Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy | Q40437444 |
| | Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway | Q40620552 |
| | Regulation of leptin secretion from white adipocytes by free fatty acids | Q42440847 |
| | Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes | Q42460893 |
| | The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. | Q42804257 |
| | Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2. | Q42805819 |
| | Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. | Q42829442 |
| | Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis | Q42831589 |
| | Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice | Q43966288 |
| | Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes | Q44007180 |
| | Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats. | Q44286316 |
| | Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes | Q44564021 |
| | Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog | Q44599780 |
| | Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes | Q44675026 |
| | Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice | Q44804017 |
| | Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. | Q44814519 |
| | PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. | Q44859720 |
| | SREBPs suppress IRS-2-mediated insulin signalling in the liver | Q47868873 |
| | Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. | Q48702756 |
| | Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. | Q52174749 |
| | Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 718-727 | |
| P577 | publication date | 2005-03-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism | |
| P478 | volume | 115 | |