Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

scientific article published on August 1, 1995

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI118126
P953full work available at URLhttp://www.jci.org/articles/view/118126/files/pdf
https://europepmc.org/articles/PMC185266
https://europepmc.org/articles/PMC185266?pdf=render
P932PMC publication ID185266
P698PubMed publication ID7635975

P2093author name stringJ. Xia
Z. Tang
A. Dunaif
E. Schenker
C. B. Book
P2860cites workMembrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitusQ24310636
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesQ28615460
Detection and quantification of phosphotyrosine in proteinsQ29620010
Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodiesQ33255501
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificityQ33880454
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetesQ34330770
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cellsQ34333417
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjectsQ34556125
Polycystic ovaries--a common finding in normal womenQ34560172
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetesQ34570368
Insulin Receptors in Human Circulating Cells and FibroblastsQ34695611
Mutations in the insulin receptor geneQ35235087
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight lossQ35591970
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dietingQ35905106
Activation of glucose transport by a natural mutation in the human insulin receptorQ36027353
Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2AQ36178824
Genotyping Steroid 21-Hydroxylase Deficiency: Hormonal Reference Data*Q36597628
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptorQ37169141
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activityQ37393990
Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetesQ38756306
Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic femalesQ41152334
Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes.Q41451189
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinaseQ41488389
Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free systemQ41560390
Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cellsQ41669214
Phosphorylation of the insulin receptor by a casein kinase I-like enzymeQ41674861
A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylationQ41700016
Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cellsQ41724208
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.Q42123948
Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitroQ42453186
Production of Inhibitor of Insulin-Receptor Tyrosine Kinase in Fibroblasts From Patient With Insulin Resistance and NIDDMQ42470894
Insulin-receptor autophosphorylation and kinase activity are constitutively increased in fibroblasts cultured from a patient with heritable insulin-resistanceQ42479570
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistanceQ42483454
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndromeQ42497234
Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolismQ42507578
Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutationQ42508257
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemiaQ42517167
Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mappingQ42803039
Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptorsQ42803968
Homogeneous functional insulin receptor from 3T3-L1 adipocytes. Purification using N alpha B1-(biotinyl-epsilon-aminocaproyl)insulin and avidin-sepharoseQ42815866
Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C.Q42833336
Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populationsQ43490466
Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr.Q44788399
Detection of Mutations in Insulin Receptor Gene by Denaturing Gradient Gel ElectrophoresisQ45013094
Kinetics of insulin binding and kinase activity of the partially purified insulin receptor from human skeletal muscleQ45218706
Cellular mechanisms of insulin resistance in polycystic ovarian syndromeQ46524009
Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.Q46549798
In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment.Q51604694
Acanthosis Nigricans, insulin action, and hyperandrogenism: clinical, histological, and biochemical findings.Q51609532
Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome.Q53814172
Insulin resistance improves in hyperandrogenic women treated with Lupron.Q54229012
Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes.Q54248306
Effects of testosterone on muscle insulin sensitivity and morphology in female rats.Q54314598
Phosphorylation of purified insulin receptor by cAMP kinase.Q54415183
Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndromeQ67273627
Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndromeQ67555170
The plasma cell membrane glycoprotein, PC-1, is a threonine-specific protein kinase stimulated by acidic fibroblast growth factorQ67699210
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitroQ69819344
Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activityQ70141433
Insulin stimulates phosphorylation of serine residues in soluble insulin receptorsQ70178689
Mechanisms of impaired insulin action in isolated adipocytes from obese and diabetic subjectsQ70235999
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activityQ70377235
Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistanceQ70402792
Characterization of the Somatomedin-C/Insulin-Like Growth Factor I (SM-C/IGF-I) Receptor on Cultured Human Fibroblast Monolayers: Regulation of Receptor Concentrations by SM-C/IGF-I and Insulin*Q72936396
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
insulin resistanceQ1053470
polycystic ovaryQ5547896
polycystic ovary syndromeQ500816
post-translational protein modificationQ898362
P304page(s)801-810
P577publication date1995-08-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleExcessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
P478volume96