| scholarly article | Q13442814 |
| P2093 | author name string | R Suzuki | |
| W S Chen | |||
| K Tobe | |||
| T Kadowaki | |||
| M L Chen | |||
| N Hay | |||
| W Weng | |||
| P Z Xu | |||
| I Roninson | |||
| K Gottlob | |||
| K Sokol | |||
| T Shiyanova | |||
| P2860 | cites work | Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. | Q40913396 |
| Heregulin regulation of Akt/protein kinase B in breast cancer cells | Q40936401 | ||
| Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells | Q41029421 | ||
| The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. | Q41120735 | ||
| Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer | Q41173693 | ||
| Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. | Q41294455 | ||
| Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. | Q41678258 | ||
| Mechanism of activation and function of protein kinase B. | Q41732739 | ||
| Mechanisms and consequences of activation of protein kinase B/Akt | Q41751003 | ||
| Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes | Q42801336 | ||
| Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin | Q42829524 | ||
| Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. | Q42991716 | ||
| Age-related histologic changes in the adult mouse testis. | Q43524522 | ||
| PIK3CA is implicated as an oncogene in ovarian cancer. | Q46015944 | ||
| Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways | Q47070325 | ||
| PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. | Q47072188 | ||
| Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. | Q52183100 | ||
| Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. | Q52512624 | ||
| Thymocyte apoptosis induced by p53-dependent and independent pathways. | Q54242475 | ||
| Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation | Q24322925 | ||
| Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA | Q24568308 | ||
| Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma | Q24604935 | ||
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| PTEN: life as a tumor suppressor | Q28203431 | ||
| Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos | Q28512106 | ||
| Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene | Q28512170 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells | Q28586458 | ||
| Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor | Q28611335 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| p53 is required for radiation-induced apoptosis in mouse thymocytes | Q29620281 | ||
| Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway | Q30829981 | ||
| Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility | Q30835829 | ||
| The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. | Q33783562 | ||
| Ras signalling and apoptosis | Q34746668 | ||
| Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo | Q36368472 | ||
| Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome | Q36570848 | ||
| The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila | Q39120031 | ||
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | apoptotic process | Q14599311 |
| homozygosity | Q114049690 | ||
| P304 | page(s) | 2203-8 | |
| P577 | publication date | 2001-09-01 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene | |
| P478 | volume | 15 |
| Q37013219 | 14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly |
| Q40484912 | A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death |
| Q90729602 | A Review of Complementary and Alternative Medicine Therapies on Muscular Atrophy: A Literature Review of In Vivo/In Vitro Studies |
| Q36156412 | A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. |
| Q39015140 | A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer |
| Q24598593 | A mosaic activating mutation in AKT1 associated with the Proteus syndrome |
| Q39315073 | A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. |
| Q93018670 | A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 |
| Q52731012 | A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206. |
| Q42326649 | ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β. |
| Q40857000 | AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development |
| Q37045823 | AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma |
| Q68692596 | AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions |
| Q36563578 | AKT signaling in ERBB2-amplified breast cancer |
| Q30471196 | AKT signaling mediates IGF-I survival actions on otic neural progenitors |
| Q35128548 | AKT signalling in the failing heart |
| Q42511240 | AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation |
| Q39255027 | AKT/PKB Signaling: Navigating the Network |
| Q39623578 | AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model that Mimics Some Features of Basal Cell Nevus Syndrome |
| Q34786288 | AKT1 G205T genotype influences obesity-related metabolic phenotypes and their responses to aerobic exercise training in older Caucasians |
| Q33871498 | AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. |
| Q42491656 | AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes |
| Q36650845 | AKT2 confers protection against aortic aneurysms and dissections |
| Q37405232 | AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. |
| Q28590308 | Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity |
| Q36733736 | Achieving specificity in Akt signaling in cancer |
| Q38824661 | Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling |
| Q36226730 | Activation of AKT kinases in cancer: implications for therapeutic targeting |
| Q24537734 | Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage |
| Q42277432 | Adi3 is a Pdk1-interacting AGC kinase that negatively regulates plant cell death |
| Q46390661 | Age-related changes of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: an immunohistochemical study |
| Q92494933 | Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis |
| Q35445077 | Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer |
| Q35684972 | Akt and PTEN: beta-cell mass and pancreas plasticity. |
| Q39338602 | Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). |
| Q42525511 | Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts |
| Q28749276 | Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition |
| Q37018918 | Akt in the pathogenesis of COPD. |
| Q36917074 | Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents |
| Q38288465 | Akt is a downstream target of NF-kappa B. |
| Q34989027 | Akt is required for Stat5 activation and mammary differentiation |
| Q101038777 | Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model |
| Q37800267 | Akt isoforms and glucose homeostasis – the leptin connection |
| Q42276923 | Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities |
| Q30494741 | Akt isoforms differentially regulate neutrophil functions |
| Q26851565 | Akt isoforms in vascular disease |
| Q92069609 | Akt modes of stem cell regulation: more than meets the eye? |
| Q33923074 | Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis |
| Q39787858 | Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation |
| Q43179256 | Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction |
| Q33187686 | Akt signaling regulates side population cell phenotype via Bcrp1 translocation. |
| Q46968816 | Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways". |
| Q37525730 | Akt-mediated foxo1 inhibition is required for liver regeneration. |
| Q33951903 | Akt/PKB regulates laminin and collagen IV isotypes of the basement membrane |
| Q34162552 | Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development |
| Q34276940 | Akt/protein kinase B promotes organ growth in transgenic mice |
| Q47134589 | Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. |
| Q37488229 | Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development |
| Q35151491 | Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer |
| Q30479413 | Akt1 governs breast cancer progression in vivo |
| Q24676614 | Akt1 in endothelial cell and angiogenesis |
| Q33303666 | Akt1 in osteoblasts and osteoclasts controls bone remodeling |
| Q33905832 | Akt1 in the cardiovascular system: friend or foe? |
| Q37321172 | Akt1 is critical for acute inflammation and histamine-mediated vascular leakage |
| Q37179782 | Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing |
| Q37163727 | Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations. |
| Q34559260 | Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling |
| Q34550955 | Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil |
| Q24648140 | Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo |
| Q37318533 | Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly |
| Q42818650 | Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation |
| Q45151645 | Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors |
| Q42482049 | Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis |
| Q37326916 | Akt2 and SGK3 are both determinants of postnatal hair follicle development. |
| Q37079752 | Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis |
| Q38349186 | Akt2 is required for hepatic lipid accumulation in models of insulin resistance. |
| Q33885216 | Akt2 modulates glucose availability and downstream apoptotic pathways during development |
| Q40567186 | Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis |
| Q30491624 | Akt3 is responsible for the survival and proliferation of embryonic stem cells |
| Q92564624 | Akt3-Mediated Protection Against Inflammatory Demyelinating Disease |
| Q34223641 | Akt: a double-edged sword in cell proliferation and genome stability |
| Q30414943 | All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear. |
| Q41906729 | An Analysis of the Effects and the Molecular Mechanism of Deep Hypothermic Low Flow on Brain Tissue in Mice |
| Q35483767 | An important role for Akt3 in platelet activation and thrombosis |
| Q42292341 | Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells. |
| Q34872991 | Anaphylactic shock depends on PI3K and eNOS-derived NO. |
| Q34157973 | Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. |
| Q33673656 | Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts |
| Q47389306 | BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma. |
| Q37643727 | Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3. |
| Q42110947 | Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. |
| Q64040124 | Brown fat organogenesis and maintenance requires AKT1 and AKT2 |
| Q36370844 | CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. |
| Q24304964 | COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ |
| Q41850815 | Calcineurin and Akt expression in hypertrophied bladder in STZ-induced diabetic rat |
| Q34401014 | Calcineurin signaling regulates human islet {beta}-cell survival. |
| Q36876219 | Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue |
| Q41912188 | Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. |
| Q40285359 | Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways |
| Q52730249 | Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. |
| Q54356163 | Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum. |
| Q36535062 | Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells |
| Q39165973 | Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma |
| Q54964493 | Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma. |
| Q36626353 | Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease |
| Q79736219 | Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha |
| Q52714549 | Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism. |
| Q37574344 | Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy |
| Q26801402 | Connecting Myokines and Metabolism |
| Q47834227 | Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts |
| Q36325901 | Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling |
| Q28305487 | Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity |
| Q42132463 | Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure |
| Q29614735 | Critical nodes in signalling pathways: insights into insulin action |
| Q36968719 | Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis |
| Q27640282 | Crystal structure of an inactive Akt2 kinase domain |
| Q50027040 | Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis |
| Q36547537 | Cytoskeletal keratin glycosylation protects epithelial tissue from injury. |
| Q37642435 | DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. |
| Q35931063 | Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm |
| Q37631255 | Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice |
| Q40051013 | Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells |
| Q28510115 | Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation |
| Q36246003 | Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia |
| Q33301344 | Deletion of PKBalpha/Akt1 affects thymic development |
| Q36159631 | Development of a new model system to dissect isoform specific Akt signalling in adipocytes |
| Q36543648 | Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) |
| Q36388391 | Dichotomy effects of Akt signaling in breast cancer |
| Q44060026 | Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes |
| Q38532367 | Differential control of muscle mass in type 1 and type 2 diabetes mellitus |
| Q33614014 | Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. |
| Q54979781 | Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression. |
| Q52681513 | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. |
| Q42928039 | Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure |
| Q33854404 | Distinct roles of the three Akt isoforms in lactogenic differentiation and involution |
| Q84338645 | Does obesity reduce load-induced muscle hypertrophy? |
| Q34150841 | Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice |
| Q40324361 | Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function |
| Q35965439 | Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. |
| Q90410784 | EXP2SL: A Machine Learning Framework for Cell-Line-Specific Synthetic Lethality Prediction |
| Q42052161 | Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. |
| Q99555085 | Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation |
| Q34144300 | Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates |
| Q49960687 | Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis |
| Q55061628 | Enhanced sensitivity to sorafenib by inhibition of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in vivo. |
| Q37107596 | Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1. |
| Q24685447 | Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway |
| Q24534217 | Essential role of PDK1 in regulating cell size and development in mice |
| Q34443608 | Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. |
| Q37160832 | Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTOR signaling pathway |
| Q52098567 | Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium. |
| Q24676637 | FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal |
| Q64114315 | Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development |
| Q64279460 | Fibroblast growth factor 16 stimulates proliferation but blocks differentiation of rat stem Leydig cells during regeneration |
| Q92925829 | Fibroblast growth factor homologous factor 1 stimulates Leydig cell regeneration from stem cells in male rats |
| Q37628713 | Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research |
| Q40491343 | Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. |
| Q37285629 | Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. |
| Q33837547 | Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome |
| Q40106100 | Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly |
| Q34594275 | Genetic analysis of insulin signaling in Drosophila |
| Q33664428 | Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation |
| Q37305035 | Genetic modelling of the PTEN/AKT pathway in cancer research |
| Q50613740 | Germline activating AKT3 mutation associated with megalencephaly, polymicrogyria, epilepsy and hypoglycemia. |
| Q34991079 | Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells |
| Q57833109 | Global Approaches to Understanding Protein Kinase Functions |
| Q48180769 | Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration. |
| Q99637144 | Growth retardation-responsive analysis of mRNAs and long noncoding RNAs in the liver tissue of Leiqiong cattle |
| Q92093680 | HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity |
| Q28296350 | Haploinsufficiency of akt1 prolongs the lifespan of mice |
| Q39670813 | Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). |
| Q47800119 | Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines |
| Q44208213 | High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway |
| Q35958188 | Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices |
| Q39079705 | IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro |
| Q36403372 | ILK, PINCH and parvin: the tIPP of integrin signalling |
| Q28592943 | Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN |
| Q30811594 | Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1 |
| Q39461675 | Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity. |
| Q24338582 | Identification of a proline-rich Akt substrate as a 14-3-3 binding partner |
| Q55248735 | Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis. |
| Q53532887 | Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors. |
| Q47845168 | Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis, and metabolism in adipose tissue in the sheep fetus |
| Q36936246 | Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle |
| Q35039102 | Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice |
| Q47365909 | Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice |
| Q42136011 | In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis |
| Q39565163 | Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. |
| Q37131039 | Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. |
| Q47140124 | Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks. |
| Q40508864 | Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. |
| Q28202566 | Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells |
| Q37071544 | Inhibition of glycogen synthase kinase-3β prevents sympathetic hyperinnervation in infarcted rats |
| Q34145575 | Inhibition of protein kinase B/Akt. implications for cancer therapy |
| Q37099725 | Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT) |
| Q42592859 | Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 |
| Q38124366 | Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes. |
| Q43245108 | Insulin resistance and muscle metabolism in chronic kidney disease |
| Q35940001 | Insulin signaling in heart muscle: lessons from genetically engineered mouse models. |
| Q37501407 | Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle |
| Q36757048 | Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival |
| Q34341479 | Interferons mediate terminal differentiation of human cortical thymic epithelial cells |
| Q37618760 | Interrelationships between apoptosis and fertility in bull sperm |
| Q39240626 | Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells |
| Q47673795 | Involvement of Akt1/protein kinase Balpha in tumor conditioned medium-induced endothelial cell migration and survival in vitro |
| Q42801589 | Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient Wv/Wv mutant mice |
| Q35584909 | Involvement of the Akt/PKB signaling pathway with disease processes |
| Q50760024 | It's a knockout! Male infertility and neuropathology. |
| Q34260055 | JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling |
| Q24307898 | Kinetic mechanism of AKT/PKB enzyme family |
| Q38205763 | Knockout mouse models of insulin signaling: Relevance past and future |
| Q37040174 | Lack of AKT in adipocytes causes severe lipodystrophy. |
| Q41997926 | Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. |
| Q33569852 | Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function |
| Q24672400 | Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies |
| Q90642854 | Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice |
| Q40313842 | Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity |
| Q36753752 | Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease |
| Q40464853 | Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. |
| Q34988349 | Lymphocide: cytokines and the control of lymphoid homeostasis |
| Q49905672 | MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development. |
| Q39115033 | MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines |
| Q36196806 | Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice |
| Q21245465 | Main roads to melanoma |
| Q28246430 | Mammalian SIRT1 represses forkhead transcription factors |
| Q40576965 | Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism |
| Q42519955 | Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. |
| Q26751659 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours |
| Q48338576 | Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment. |
| Q34935025 | Microarray analysis of gene expression profiles of Schistosoma japonicum derived from less-susceptible host water buffalo and susceptible host goat |
| Q37941864 | Mitochondrial regulation of cell cycle and proliferation |
| Q34487795 | Model organisms as a guide to mammalian aging |
| Q35681316 | Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies |
| Q36378398 | Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235 |
| Q50423780 | Molecular Regulation of Sprouting Angiogenesis |
| Q89812634 | Molecular and cellular underpinnings of normal and abnormal human placental blood flows |
| Q27006868 | Molecular basis of physiological heart growth: fundamental concepts and new players |
| Q35893223 | Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| Q35469289 | Molecular mechanism of size control in development and human diseases |
| Q35203025 | Molecular mechanisms modulating muscle mass |
| Q58756704 | Morphology regulation in vascular endothelial cells |
| Q24632718 | Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA |
| Q33915992 | Multiple roles and therapeutic implications of Akt signaling in cancer. |
| Q36941459 | Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle |
| Q40410776 | Mutant PIK3CA promotes cell growth and invasion of human cancer cells |
| Q27650096 | Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance |
| Q36908289 | Myocardial AKT: the omnipresent nexus |
| Q39674949 | Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. |
| Q40305915 | Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt. |
| Q33267049 | Neuroprotection and enhancement of neurite outgrowth with small molecular weight compounds from screens of chemical libraries |
| Q37629872 | Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish |
| Q34942342 | Neurotrophic factors and axonal growth |
| Q30575274 | Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation |
| Q52644526 | New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. |
| Q36267711 | Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation |
| Q44555527 | Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis |
| Q39555624 | Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. |
| Q28505512 | Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death |
| Q34564794 | Normal T-cell development and immune functions in TRIM-deficient mice |
| Q33818946 | Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. |
| Q37445903 | Novel HIV-1 therapeutics through targeting altered host cell pathways |
| Q28546072 | Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells |
| Q35595721 | Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice |
| Q36565904 | Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates |
| Q42811747 | Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. |
| Q36272908 | Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. |
| Q36292251 | Nutrition regulation of male accessory gland growth and maturation in Tribolium castaneum |
| Q37287406 | OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression. |
| Q42091923 | Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. |
| Q37568650 | Obestatin as a regulator of adipocyte metabolism and adipogenesis |
| Q36576524 | On the role of IRS2 in the regulation of functional beta-cell mass |
| Q91259716 | Oncogenic AKTivation by methylation |
| Q39126224 | Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. |
| Q38549724 | Organ-Size Regulation in Mammals |
| Q57464711 | Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage |
| Q33341346 | PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle |
| Q24300933 | PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms |
| Q26862544 | PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms |
| Q35980515 | PI3K/AKT signaling and systemic autoimmunity |
| Q37974734 | PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. |
| Q37310202 | PI3K/Akt: getting it right matters |
| Q28383083 | PI3K/PTEN signaling in angiogenesis and tumorigenesis |
| Q28609463 | PIP3 pathway in regulatory T cells and autoimmunity |
| Q34389540 | PKB/AKT: functional insights from genetic models |
| Q34942330 | PTEN function in mammalian cell size regulation |
| Q28239790 | PTEN is a protein tyrosine phosphatase for IRS1 |
| Q37270423 | PTEN signaling in brain: neuropathology and tumorigenesis. |
| Q64075627 | Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt |
| Q28586031 | Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription |
| Q27314984 | Park7 expression influences myotube size and myosin expression in muscle |
| Q42166673 | Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. |
| Q33948355 | Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression. |
| Q37563586 | Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis |
| Q36461618 | Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
| Q41880113 | Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. |
| Q35003522 | Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy |
| Q48309099 | Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter |
| Q28566913 | Possible molecular mechanisms underlying age-related cardiomyocyte apoptosis in the F344XBN rat heart |
| Q27027815 | Posttranslational regulation of Akt in human cancer |
| Q39682060 | Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP |
| Q36545796 | Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy |
| Q45824089 | Promyelocytic leukaemia zinc finger maintains self-renewal of male germline stem cells (mGSCs) and its expression pattern in dairy goat testis |
| Q92105406 | Propofol Inhibits Androgen Production in Rat Immature Leydig Cells |
| Q36292074 | Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain |
| Q36307952 | Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol |
| Q38687010 | Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis |
| Q34666940 | Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration |
| Q89692473 | Putative functional variants of PI3K/AKT/mTOR pathway are associated with knee osteoarthritis susceptibility |
| Q42702654 | Quercetin regresses Dalton's lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism |
| Q36234263 | RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development |
| Q35235848 | Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity |
| Q36997524 | Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment |
| Q41837867 | Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth |
| Q35174581 | Redox regulation of protein kinases |
| Q35144025 | Regeneration therapy for diabetes mellitus |
| Q26998765 | Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging |
| Q29248612 | Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases |
| Q45035896 | Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase B-mediated microtubule stabilization |
| Q29615166 | Regulation of cardiac hypertrophy by intracellular signalling pathways |
| Q38131857 | Regulation of placental angiogenesis |
| Q35128706 | Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models |
| Q36364259 | Regulation of the PI3K/Akt pathway during decidualization of endometrial stromal cells |
| Q35923996 | Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis |
| Q35176637 | Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity. |
| Q46674979 | Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs |
| Q46940974 | Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia |
| Q28509294 | Role for Akt3/protein kinase Bgamma in attainment of normal brain size |
| Q35634446 | Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons |
| Q36853917 | Role for neuronal insulin resistance in neurodegenerative diseases |
| Q38030851 | Role of AGC kinases in plant growth and stress responses |
| Q34997136 | Role of Akt/protein kinase B in metabolism. |
| Q42497456 | Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle |
| Q34866669 | Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway. |
| Q55071609 | Role of mTOR Complexes in Neurogenesis. |
| Q37281658 | Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis |
| Q35203309 | Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies. |
| Q36534292 | Role of the Akt pathway in mRNA translation of interferon-stimulated genes |
| Q36138723 | Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth |
| Q46296313 | S-Nitrosylation inhibits the kinase activity of tomato phosphoinositide-dependent kinase 1 (PDK1). |
| Q30399129 | SGK1: The Dark Side of PI3K Signaling |
| Q36072704 | SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption |
| Q42831990 | SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes |
| Q33861469 | SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease |
| Q42355569 | SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis |
| Q24669877 | Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta |
| Q36449314 | Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats |
| Q42044656 | Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts. |
| Q33775212 | Signaling specificity in the Akt pathway in biology and disease |
| Q28206750 | Signalling pathways that mediate skeletal muscle hypertrophy and atrophy |
| Q38252278 | Signalling specificity in the Akt pathway in breast cancer |
| Q41296905 | Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice |
| Q39286426 | Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis |
| Q37038522 | Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. |
| Q47160893 | Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. |
| Q43268934 | Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1. |
| Q36588130 | Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling |
| Q36573021 | Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice |
| Q28509136 | Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis |
| Q90913033 | Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice |
| Q44588837 | Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions |
| Q38851407 | Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration |
| Q28584959 | TCL1 participates in early embryonic development and is overexpressed in human seminomas |
| Q35041204 | TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR) |
| Q37497352 | Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development |
| Q26863340 | Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy |
| Q27022941 | Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma |
| Q37872655 | Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs |
| Q35023287 | Targeting the Akt/mTOR pathway in Brca1-deficient cancers |
| Q58696619 | Tetrahydroxystilbene Glucoside Regulates Proliferation, Differentiation, and OPG/RANKL/M-CSF Expression in MC3T3-E1 Cells via the PI3K/Akt Pathway |
| Q34116730 | The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane |
| Q38472472 | The Akt isoforms, their unique functions and potential as anticancer therapeutic targets |
| Q37549798 | The Akt kinases: isoform specificity in metabolism and cancer |
| Q35986496 | The Akt signaling pathway is required for tissue maintenance and regeneration in planarians |
| Q36313193 | The Akt/PKB pathway: molecular target for cancer drug discovery |
| Q37294231 | The Akt1 isoform is an essential mediator of ischaemic preconditioning |
| Q36856314 | The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin |
| Q28212977 | The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells |
| Q64964485 | The Glp-1 Analog Liraglutide Protects Against Angiotensin II and Pressure Overload-Induced Cardiac Hypertrophy via PI3K/Akt1 and AMPKa Signaling. |
| Q28610410 | The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 |
| Q33327777 | The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation |
| Q34432494 | The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo |
| Q34766011 | The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. |
| Q33699378 | The PIK3CA gene as a mutated target for cancer therapy |
| Q38121538 | The Role of PTEN in β-Cell Growth. |
| Q40813679 | The T-loop extension of the tomato protein kinase AvrPto-dependent Pto-interacting protein 3 (Adi3) directs nuclear localization for suppression of plant cell death. |
| Q34560188 | The WNKs: atypical protein kinases with pleiotropic actions. |
| Q34580081 | The Warburg effect and its cancer therapeutic implications |
| Q59282167 | The anti-apoptotic role of PPARβ contributes to efficient skin wound healing |
| Q36752770 | The beginning of the end: death signaling in early involution |
| Q34693888 | The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice |
| Q35814450 | The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. |
| Q36527188 | The eIF4E RNA regulon promotes the Akt signaling pathway |
| Q35738371 | The effect Akt2 deletion on tumor development in Pten(+/-) mice. |
| Q35913175 | The effect of exercise on expression of myokine and angiogenesis mRNA in skeletal muscle of high fat diet induced obese rat. |
| Q37151504 | The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription |
| Q27325606 | The hemodynamic basis for positional- and inter-fetal dependent effects in dual arterial supply of mouse pregnancies |
| Q28575434 | The loss of glypican-3 induces alterations in Wnt signaling |
| Q39297991 | The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. |
| Q40361919 | The masticatory contractile load induced expression and activation of Akt1/PKBalpha in muscle fibers at the myotendinous junction within muscle-tendon-bone unit |
| Q36745379 | The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer |
| Q29547860 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer |
| Q40351374 | The phosphoinositide 3-kinase/Akt pathway is essential for the retinoic acid-induced differentiation of F9 cells |
| Q37087125 | The potential roles for embryotrophic ligands in preimplantation embryo development |
| Q35661688 | The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas |
| Q53652464 | The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling. |
| Q35844958 | The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. |
| Q38740114 | The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. |
| Q37954130 | The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes. |
| Q39530992 | The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo |
| Q38175044 | The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development |
| Q41600042 | The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion |
| Q54511996 | The β-subunit of the SnRK1 complex is phosphorylated by the plant cell death suppressor Adi3. |
| Q24631438 | Therapeutic Implications of Targeting AKT Signaling in Melanoma |
| Q35832894 | Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy |
| Q35080579 | Tissue-specific targeting of the insulin receptor gene |
| Q36461109 | Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury |
| Q36873743 | Transcriptional regulation of serine/threonine protein kinase (AKT) genes by glioma-associated oncogene homolog 1. |
| Q91692599 | Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways |
| Q34286691 | Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation |
| Q54119830 | Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice. |
| Q44617813 | Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases |
| Q80593225 | Up-regulation of the phosphoinositide 3-kinase pathway in human lamina propria T lymphocytes |
| Q30925087 | Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions |
| Q24318997 | VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase |
| Q37946372 | What we have learnt about PIKE from the knockout mice |
| Q44559365 | Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt |
| Q28252695 | mTOR signaling in tumorigenesis |
| Q26864688 | mTOR-dependent cell survival mechanisms |
| Q51417912 | miR-25-3p, Positively Regulated by Transcription Factor AP-2α, Regulates the Metabolism of C2C12 Cells by Targeting Akt1. |
| Q53856246 | p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation. |
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