| scholarly article | Q13442814 |
| P50 | author | Brian Hemmings | Q4964012 |
| P2093 | author name string | Hundal HS | |
| Alessi DR | |||
| Hajduch E | |||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1006-1013 | |
| P577 | publication date | 1998-07-01 | |
| P1433 | published in | Diabetes | Q895262 |
| P1476 | title | Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells | |
| P478 | volume | 47 |
| Q31592106 | 3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells |
| Q39315073 | A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. |
| Q40380384 | A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration. |
| Q33960388 | A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes |
| Q40839096 | A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B. |
| Q34486765 | AKT1 polymorphisms are associated with risk for metabolic syndrome. |
| Q44559074 | ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling |
| Q46562392 | Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells |
| Q43604469 | Activation of skeletal muscle protein breakdown following consumption of soyabean protein in pigs |
| Q36299173 | Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation |
| Q28749276 | Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition |
| Q42503051 | Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes |
| Q28568090 | Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin |
| Q35082201 | Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells |
| Q35225044 | Anabolic effect of plant brassinosteroid. |
| Q31967319 | Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle |
| Q37112535 | Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: potential mechanisms and clinical relevance |
| Q35103622 | Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. |
| Q35586717 | Body building: regulation of shape and size by PI3K/TOR signaling during development |
| Q40174504 | C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. |
| Q64916762 | CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation. |
| Q52891193 | Calorie restriction increases insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 in rat skeletal muscle. |
| Q89851622 | Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function |
| Q42472548 | Cellular depletion of atypical PKC{lambda} is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells. |
| Q36311897 | Cellular location of insulin-triggered signals and implications for glucose uptake |
| Q39940319 | Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. |
| Q33945735 | Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight |
| Q27316876 | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells |
| Q36592817 | Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. |
| Q50526646 | Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase. |
| Q44137084 | Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation |
| Q36016832 | Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells |
| Q37076486 | Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate |
| Q46724454 | Developmental regulation of protein kinase B activation is isoform specific in skeletal muscle of neonatal pigs |
| Q42809889 | Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes |
| Q34544900 | Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells |
| Q40775117 | Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport |
| Q40649584 | Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity |
| Q53554484 | Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability. |
| Q34798731 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus? |
| Q36958371 | Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib |
| Q44626594 | Effect of glycogen synthase overexpression on insulin-stimulated muscle glucose uptake and storage |
| Q50290125 | Effects of Sodium and Amino Acid Substrate Availability upon the Expression and Stability of the SNAT2 (SLC38A2) Amino Acid Transporter |
| Q43800996 | Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats |
| Q44785416 | Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice |
| Q37791182 | Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms |
| Q58695917 | Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury |
| Q39456738 | Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells |
| Q44788609 | Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle |
| Q35121879 | Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. |
| Q22254159 | Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes |
| Q43794384 | Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle |
| Q38125149 | Exercise and type 1 diabetes (T1DM). |
| Q80409696 | Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats |
| Q46178215 | Expression of rainbow trout glucose transporters GLUT1 and GLUT4 during in vitro muscle cell differentiation and regulation by insulin and IGF-I. |
| Q32029923 | GLUT4--at the cross roads between membrane trafficking and signal transduction |
| Q38837034 | GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling |
| Q58566462 | Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism |
| Q39100609 | Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. |
| Q46622425 | Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B. |
| Q28349476 | Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene |
| Q34336521 | Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. |
| Q43546852 | Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells |
| Q44792800 | Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes |
| Q36854401 | Improvement of insulin sensitivity by antagonism of the renin-angiotensin system |
| Q39957963 | Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle |
| Q28366319 | Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase |
| Q42127573 | Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells |
| Q28581386 | Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle |
| Q46600057 | Inhibition of stretch-activated channels during eccentric muscle contraction attenuates p70S6K activation |
| Q40780123 | Insulin accelerates inter-endosomal GLUT4 traffic via phosphatidylinositol 3-kinase and protein kinase B. |
| Q30857888 | Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes |
| Q28581515 | Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells |
| Q34188504 | Insulin receptor substrate polymorphisms and type 2 diabetes mellitus |
| Q34221797 | Insulin regulates the expression of the GLUT5 transporter in L6 skeletal muscle cells. |
| Q40187486 | Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator |
| Q40546613 | Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells |
| Q42828593 | Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake |
| Q34754988 | Invited review: Effects of acute exercise and exercise training on insulin resistance |
| Q36719888 | Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1. |
| Q41946157 | L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-re |
| Q33784630 | Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects. |
| Q42823745 | Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation |
| Q33869415 | Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice |
| Q24311397 | Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells |
| Q42829443 | Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2. |
| Q39808087 | NAD(P)H oxidase isoform Nox2 plays a prosurvival role in human leukaemia cells |
| Q33853693 | Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes |
| Q44059073 | Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity |
| Q33958497 | Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state |
| Q42817438 | Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation |
| Q34964128 | Peripheral effects of nesfatin-1 on glucose homeostasis |
| Q42804994 | Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells |
| Q42472986 | Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence |
| Q35610595 | Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders |
| Q33688611 | Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling |
| Q92126409 | Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading |
| Q41963892 | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability |
| Q34189344 | Protein kinase B (PKB/Akt)--a key regulator of glucose transport? |
| Q42991716 | Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. |
| Q35212085 | Protein kinase B in the diabetic heart |
| Q36232723 | Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins |
| Q39022338 | Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. |
| Q33651661 | Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts |
| Q37822940 | Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance. |
| Q40177903 | Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance |
| Q41678258 | Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. |
| Q33604478 | Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells |
| Q40983592 | Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress |
| Q40912879 | Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways |
| Q41998747 | Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator |
| Q34790987 | Responding to hypoxia: lessons from a model cell line |
| Q36796704 | Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats |
| Q34997136 | Role of Akt/protein kinase B in metabolism. |
| Q42815361 | Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes |
| Q82680619 | Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle |
| Q42395469 | Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production |
| Q40036395 | Signal processes and ROS production in glucose transport regulation by thrombopoietin and granulocyte macrophage-colony stimulation factor in a human leukaemic cell line |
| Q33751847 | Signal transduction pathways that regulate eukaryotic protein synthesis |
| Q28576929 | Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells |
| Q32063485 | Spatial compartmentalization of signal transduction in insulin action |
| Q64276327 | Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells |
| Q55278796 | Sphingolipid regulators of cellular dysfunction in Type 2 diabetes mellitus: a systems overview. |
| Q33880588 | Sphingolipids in obesity, type 2 diabetes, and metabolic disease |
| Q36861002 | Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism |
| Q44303773 | Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation |
| Q28363198 | Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes |
| Q38265601 | Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE |
| Q39538318 | The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia. |
| Q24531972 | The PI3K-PDK1 connection: more than just a road to PKB |
| Q28569006 | The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells |
| Q93186275 | The Role of Ceramides in Insulin Resistance |
| Q34479104 | The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2 |
| Q35214638 | The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle |
| Q42512036 | The effects of insulin and beta-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats |
| Q58438150 | The role of PI 3-kinase in insulin action |
| Q34276379 | The role of system A for neutral amino acid transport in the regulation of cell volume |
| Q42484509 | The trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes. |
| Q38965192 | Ursolic Acid and Chronic Disease: An Overview of UA's Effects On Prevention and Treatment of Obesity and Cancer |
| Q42810034 | Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake |
| Q46932786 | Voluntary running improves in vivo insulin resistance in high-salt diet fed rats |
| Q51742198 | miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes. |
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