RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development

scientific article

RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.00676-15
P8608Fatcat IDrelease_tjcnbmyp7vcw3anxebgrw5ujyy
P932PMC publication ID4628058
P698PubMed publication ID26391954

P2093author name stringQin Li
Donny D Licatalosi
Thomas J Sweet
Molly M Hannigan
Leah L Zagore
R Michael Sramkoski
Sarah E Grabinski
P2860cites workCooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding proteinQ24551190
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brainQ24629850
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicingQ24631683
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cellsQ27693633
Context-dependent control of alternative splicing by RNA-binding proteinsQ28245737
Functional antagonism between Sall4 and Plzf defines germline progenitorsQ28261173
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrestQ28274220
Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesisQ28306927
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 geneQ28349476
Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesisQ28507616
CIB1 is essential for mouse spermatogenesisQ28510020
GATA4 regulates Sertoli cell function and fertility in adult male miceQ28510930
Identification of spermatogonial stem cell subsets by morphological analysis and prospective isolationQ39807451
Acrosome biogenesis: Revisiting old questions to yield new insightsQ40830245
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networksQ41884066
Cellular source and mechanisms of high transcriptome complexity in the mammalian testisQ42773838
Sertoli cell vacuolization and abnormal germ cell adhesion in mice deficient in an inositol polyphosphate 5-phosphataseQ43967677
The mammalian spermatozoonQ46773040
Tissue-specific alternative splicing remodels protein-protein interaction networksQ48455031
Novel modes of splicing repression by PTB.Q48548603
Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brainQ48964426
Differential transcription of Pgk genes during spermatogenesis in the mouse.Q52229498
Aflatoxin treatment brings about generation of multinucleate giant spermatids (symplasts) through opening of cytoplasmic bridges: light and transmission electron microscopic study in Swiss mouse.Q52580383
A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewalQ74409471
Flow cytometric method to isolate round spermatids from mouse testisQ74662127
The central role of Sertoli cells in spermatogenesisQ77545583
Polypyrimidine tract binding protein 2 stabilizes phosphoglycerate kinase 2 mRNA in murine male germ cells by binding to its 3'UTRQ79848415
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicingQ28512596
FNDC3A is required for adhesion between spermatids and Sertoli cellsQ28513786
Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expressionQ28593820
RNA processing and its regulation: global insights into biological networksQ29615182
Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterizationQ29619534
Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cellsQ30411261
'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cellsQ33196070
Chromatic shifts in the fluorescence emitted by murine thymocytes stained with Hoechst 33342.Q33205430
Flow cytometric characterization of viable meiotic and postmeiotic cells by Hoechst 33342 in mouse spermatogenesisQ33213050
Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1Q33293249
An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence dataQ33518463
Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic miceQ33724947
Flow cytometry purification of mouse meiotic cellsQ33883290
Nucleosome occupancy landscape and dynamics at mouse recombination hotspotsQ33962076
The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situQ34085833
Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell developmentQ34464536
Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5' splice site choiceQ34465902
Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion moleculeQ34564800
Building robust transcriptomes with master splicing factorsQ34569535
Optimized flow cytometry isolation of murine spermatocytesQ34582613
Functional consequences of developmentally regulated alternative splicingQ34632366
Male germ cell gene expressionQ34643898
Flow cytometric fluorescence emission spectrum analysis of Hoechst-33342-stained DNA in chicken thymocytesQ35010850
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neuronsQ35855671
Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesisQ36066528
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2.Q36174640
Flow-cytometric detection of changes in the fluorescence emission spectrum of a vital DNA-specific dye in human tumour cellsQ36497676
A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cellsQ37014717
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturationQ37494929
The splicing landscape is globally reprogrammed during male meiosisQ37528828
Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Δ) miceQ37570126
Staging of mouse seminiferous tubule cross-sectionsQ37580817
Good planning and serendipity: exploiting the Cre/Lox system in the testisQ37810390
Spermatogonial stem cell functions in physiological and pathological conditions.Q38179666
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)4030-4042
P577publication date2015-09-21
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleRNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development
P478volume35

Reverse relations

cites work (P2860)
Q39295240Alternative splicing as a regulator of development and tissue identity.
Q42680105Association between RNA-binding protein Ptbp2 and germ cell injury in an experimentally-induced unilateral cryptorchidism murine model.
Q37622421BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
Q52718270Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.
Q58093878DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions
Q91135264Efficient GFP-labeling and analysis of spermatogenic cells using the IRG transgene and flow cytometry
Q88698285How alternative splicing affects membrane-trafficking dynamics
Q37437764Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing.
Q37264089MRG15 is required for pre-mRNA splicing and spermatogenesis
Q51034747Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.
Q47749058Oncogenic miR‑132 sustains proliferation and self‑renewal potential by inhibition of polypyrimidine tract‑binding protein 2 in glioblastoma cells
Q92985513PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia
Q90698885PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612
Q38715475Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis
Q90428126The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers
Q91995310Tissue-specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)

Search more.