Tissue-specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)

scientific article published on 27 February 2019

Tissue-specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update) is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/WRNA.1526
P932PMC publication ID6617714
P698PubMed publication ID30816016

P2093author name stringClinton C MacDonald
P2860cites workLocally translated mTOR controls axonal local translation in nerve injury.Q52724855
The spen family protein FPA controls alternative cleavage and polyadenylation of RNA.Q53348104
Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time.Q53496094
Hu proteins regulate polyadenylation by blocking sites containing U-rich sequences.Q53586436
Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length.Q55056466
Genome-wide atlas of alternative polyadenylation in the forage legume red cloverQ56894095
The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity.Q64950652
An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanismQ81550088
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron DiseaseQ88670295
A compendium of conserved cleavage and polyadenylation events in mammalian genesQ91132627
Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profilingQ21263194
A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific mannerQ24290769
Transcriptional activators enhance polyadenylation of mRNA precursorsQ24293440
Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognitionQ24529123
HITS-CLIP yields genome-wide insights into brain alternative RNA processingQ24648963
Systematic variation in mRNA 3'-processing signals during mouse spermatogenesisQ24670418
Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processingQ24674098
Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transitionQ24682971
Processing and transcriptome expansion at the mRNA 3' end in health and disease: finding the right endQ26746120
Mechanisms and consequences of alternative polyadenylationQ26852702
The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in miceQ28140003
CLIP identifies Nova-regulated RNA networks in the brainQ28184312
The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiationQ28298568
Polyadenylation site-specific differences in the activity of the neuronal βCstF-64 protein in PC-12 cellsQ28568965
A developmental switch in transcription factor isoforms during spermatogenesis controlled by alternative messenger RNA 3'-end formationQ28572258
Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.Q30480912
Pre-messenger RNA cleavage factor I (CFIm): potential role in alternative polyadenylation during spermatogenesisQ50315357
Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.Q51034747
Targeted 3' processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing.Q51920988
FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition.Q52104057
Widespread intronic polyadenylation diversifies immune cell transcriptomes.Q52715419
Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.Q52718270
Differences in polyadenylation site choice between somatic and male germ cellsQ33260267
Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic developmentQ33346234
A family of splice variants of CstF-64 expressed in vertebrate nervous systemsQ33417926
Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoformsQ33554183
Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond.Q33637722
Alternative polyadenylation of mRNA precursors.Q33832891
Interallelic complementation at the suppressor of forked locus of Drosophila reveals complementation between suppressor of forked proteins mutated in different regionsQ33967034
CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing.Q33983624
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.Q34027447
Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experienceQ34163285
Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewalQ34324573
Specificity factors in cytoplasmic polyadenylationQ34351577
Genetics and regulatory impact of alternative polyadenylation in human B-lymphoblastoid cellsQ34390588
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processingQ34430715
Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.Q34430722
The τCstF-64 polyadenylation protein controls genome expression in testisQ34461180
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.Q34473863
Drosophila Sex-lethal protein mediates polyadenylation switching in the female germlineQ34500830
Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expressionQ34530421
Reexamining the polyadenylation signal: were we wrong about AAUAAA?Q34628809
The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNPQ34845721
CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defectsQ35058505
Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylationQ35532398
Signals for pre-mRNA cleavage and polyadenylationQ35671541
X chromosomes, retrogenes and their role in male reproductionQ35703614
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylationQ35860663
Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional controlQ35902018
Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.Q36009451
UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR TranscriptsQ36009541
A quantitative atlas of polyadenylation in five mammalsQ36021683
NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylationQ36101647
The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in MiceQ36182348
Implications of polyadenylation in health and diseaseQ36189648
RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell DevelopmentQ36234263
An in-depth map of polyadenylation sites in cancerQ36280750
Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cellsQ36380143
Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylationQ36414738
Alternative polyadenylation: new insights from global analysesQ36418590
Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.Q36481216
TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.Q36676439
Distal Alternative Last Exons Localize mRNAs to Neural ProjectionsQ36703465
The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA DecayQ36783622
Widespread and extensive lengthening of 3' UTRs in the mammalian brainQ36800435
PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage.Q36800743
Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.Q36948804
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.Q37160188
Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.Q37408113
Role of plant RNA-binding proteins in development, stress response and genome organization.Q37414800
Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processingQ37448736
Genome-wide dynamics of alternative polyadenylation in rice.Q37461596
The splicing landscape is globally reprogrammed during male meiosisQ37528828
The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked geneQ38317290
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogasterQ38603201
Neurodegeneration and RNA-binding proteinsQ38962082
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRsQ40104739
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.Q42128098
Elevated levels of the polyadenylation factor CstF 64 enhance formation of the 1kB Testis brain RNA-binding protein (TB-RBP) mRNA in male germ cellsQ42831308
RNA truncation by premature polyadenylation attenuates human mobile element activityQ42833909
Biased alternative polyadenylation in human tissuesQ43251330
Overexpression of the CstF-64 and CPSF-160 polyadenylation protein messenger RNAs in mouse male germ cellsQ43615326
Noncanonical Alternative Polyadenylation Contributes to Gene Regulation in Response to HypoxiaQ46117985
Molecular basis for the recognition of the human AAUAAA polyadenylation signal.Q46335657
Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation.Q46559090
Alternative Polyadenylation in Human Diseases.Q47126679
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.Q47154610
Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative PolyadenylationQ47256963
Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complexQ47258918
Alternative start and termination sites of transcription drive most transcript isoform differences across human tissuesQ47334204
PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factorsQ47433820
cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.Q47802335
Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testisQ48113230
Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.Q48190052
Knockdown of pre-mRNA cleavage factor Im 25 kDa promotes neurite outgrowthQ48407497
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue4
P921main subjectbrainQ1073
messenger RNAQ188928
P304page(s)e1526
P577publication date2019-02-27
2019-07-01
P1433published inWiley interdisciplinary reviews. RNAQ26853993
P1476titleTissue-specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)
P478volume10

Reverse relations

cites work (P2860)
Q99402564Emerging Roles of the MAGE Protein Family in Stress Response Pathways
Q92080506Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation
Q89492174Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation
Q90070150SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers

Search more.