Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing.

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Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.19743
P932PMC publication ID5122456
P698PubMed publication ID27882870

P50authorSomsakul Pop WongpaleeQ85999252
Douglas L BlackQ86975303
P2093author name stringJames A Wohlschlegel
Shalini Sharma
Ajay Vashisht
Darryl Chui
P2860cites workAn ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathwayQ44540184
Trans splicing of mRNA precursorsQ44776579
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexesQ46044906
Identification of ubiquitination sites and determination of ubiquitin-chain architectures by mass spectrometryQ46068489
The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing eventQ46698520
Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG.Q47072290
Optimized fast and sensitive acquisition methods for shotgun proteomics on a quadrupole orbitrap mass spectrometerQ47847633
Novel modes of splicing repression by PTB.Q48548603
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.Q52538175
The primer extension assay.Q54452165
The evolutionary landscape of alternative splicing in vertebrate speciesQ56894874
A two-step mechanism for 5' and 3' splice-site pairingQ59095209
U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exonQ67469400
Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitroQ68133924
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicingQ70104555
A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammalsQ70744375
Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicingQ77876084
An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognitionQ80336614
Genome-wide association between branch point properties and alternative splicingQ21092523
Functional association of U2 snRNP with the ATP-independent spliceosomal complex EQ22254390
Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicingQ22254669
The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicingQ24290741
RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice siteQ24293776
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysisQ24296676
Muscleblind proteins regulate alternative splicingQ24299521
Dynamic protein-protein interaction wiring of the human spliceosomeQ24306136
Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex AQ24317598
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Q24535663
p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplexQ24537595
Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding proteinQ24551190
hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cellsQ24554786
Global regulation of alternative splicing during myogenic differentiationQ24632881
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle developmentQ24670766
Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulationQ24684890
Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1.Q39732398
Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosomeQ40025470
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.Q40395456
Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?Q41179531
Preparation of extracts from higher eukaryotesQ41981177
Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiationQ42146748
Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding proteinQ43207063
HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognitionQ43234028
Early organization of pre-mRNA during spliceosome assembly.Q44046358
Census for proteome quantificationQ44460165
RNA helicase proteins as chaperones and remodelersQ27025517
The Clothes Make the mRNA: Past and Present Trends in mRNP FashionQ27027206
Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative SplicingQ27676040
L30 binds the nascent RPL30 transcript to repress U2 snRNP recruitmentQ27933044
Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factorsQ27935763
The spliceosome: design principles of a dynamic RNP machineQ28131809
Context-dependent control of alternative splicing by RNA-binding proteinsQ28245737
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursorsQ28251112
Specific interactions between proteins implicated in splice site selection and regulated alternative splicingQ28257351
Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definitionQ28267920
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skippingQ28269954
The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulationQ28475882
A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpartQ28581499
MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3Q28584159
Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasivenessQ28593622
RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiationQ28910223
Spliceosome Structure and FunctionQ29392298
Pre-mRNA splicing: awash in a sea of proteinsQ29547272
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencingQ29547470
hnRNP proteins and the biogenesis of mRNAQ29547911
Understanding alternative splicing: towards a cellular codeQ29615085
Exon recognition in vertebrate splicingQ29615088
DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomicsQ29615322
Messenger-RNA-binding proteins and the messages they carryQ29616012
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomesQ29618293
Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteinsQ29618943
The SR protein family of splicing factors: master regulators of gene expressionQ29619935
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and functionQ31151038
P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-RasQ33359543
Polypyrimidine tract binding protein antagonizes exon definitionQ33558440
Protein composition of mammalian spliceosomes assembled in vitroQ33847099
ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosomeQ33925070
Target-decoy search strategy for mass spectrometry-based proteomicsQ34070061
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites.Q34342937
Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gelsQ34362249
Exon repression by polypyrimidine tract binding proteinQ34366378
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection methodQ34429680
Mechanisms and Regulation of Alternative Pre-mRNA SplicingQ34467642
Systematic discovery of Xist RNA binding proteinsQ34470333
Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.Q34518971
A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcriptionQ34573390
Evidence for a linear search in bimolecular 3' splice site AG selectionQ34967051
The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunitQ35131606
Evolution of SR protein and hnRNP splicing regulatory factorsQ35605779
ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificityQ35690439
Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation FactorsQ35690588
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.Q35783819
Regulation of alternative splicing by PTB and associated factors.Q36139329
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2.Q36174640
RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell DevelopmentQ36234263
A quantitative analysis software tool for mass spectrometry-based proteomicsQ36431175
Conserved intron elements repress splicing of a neuron-specific c-src exon in vitroQ36555950
The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstreamQ36570481
The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation.Q36585875
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.Q36598797
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complexQ36670430
Exon definition may facilitate splice site selection in RNAs with multiple exonsQ36713104
Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elementsQ36775793
Structure-function relationships of the polypyrimidine tract binding proteinQ36988167
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturationQ37494929
U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repressionQ37597322
From unwinding to clamping - the DEAD box RNA helicase familyQ37903659
Structure, function and regulation of spliceosomal RNA helicasesQ37998686
Exon and intron definition in pre-mRNA splicingQ38050345
Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB.Q38301627
Structure of PTB bound to RNA: specific binding and implications for splicing regulationQ38320705
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.Q38341668
The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicingQ38347681
Knocking down the expression of TRA2β inhibits the proliferation and migration of human glioma cellsQ38841643
Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complexQ39101565
RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.Q39198184
P407language of work or nameEnglishQ1860
P921main subjectribonucleoprotein complexQ417662
P577publication date2016-11-24
P1433published ineLifeQ2000008
P1476titleLarge-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing
P478volume5

Reverse relations

cites work (P2860)
Q47134651A mechanism underlying position-specific regulation of alternative splicing.
Q92129203A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons
Q49958998CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing
Q52593252In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.
Q64946284Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Q50211474The mechanisms of a mammalian splicing enhancer.
Q50066011Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Q91771235View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover

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