What we have learnt about PIKE from the knockout mice

scientific article published on 07 June 2011

What we have learnt about PIKE from the knockout mice is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3193289
P698PubMed publication ID22003435

P2093author name stringKeqiang Ye
Chi Bun Chan
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
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PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland developmentQ24295182
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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5BQ24311684
Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidaseQ24315618
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouseQ24315716
GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteinsQ24551119
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktQ24564005
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Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signalingQ28142207
Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative DisordersQ28202177
PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisQ28207557
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKEQ28217217
Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancersQ28241482
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasionQ28242382
Hormonal regulation of mouse fatty acid synthase gene transcription in liverQ28250645
Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survivalQ28251982
Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomasQ28271306
Inducible gene targeting in mice using the Cre/lox systemQ28272460
Signal transducer and activator of transcription 5A/B in prostate and breast cancersQ28281791
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1Q28285538
PIKE-A is a proto-oncogene promoting cell growth, transformation and invasionQ28287996
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PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expressionQ28511024
Pten regulates neuronal arborization and social interaction in miceQ28512488
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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neuronsQ31965209
Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytesQ33216242
Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistanceQ33750723
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PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell deathQ36762621
NMDA and AMPA receptors: old channels, new tricksQ36785630
Mammary gland involution as a multi-step processQ36790713
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity.Q36854587
Prolactin regulation of mammary gland development.Q37064933
BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK.Q37114314
GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.Q37158111
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AMPK exerts dual regulatory effects on the PI3K pathway.Q39861564
Stimulation of 3T3-L1 adipogenesis by signal transducer and activator of transcription 5.Q40721610
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The effects of AICAR on adipocyte differentiation of 3T3-L1 cellsQ40783109
Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cellsQ40900153
Layer and regional effects of environmental enrichment on the pyramidal neuron morphology of the rat.Q42451720
Theta burst stimulation is optimal for induction of LTP at both apical and basal dendritic synapses on hippocampal CA1 neuronsQ42453633
Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytesQ42796019
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide ribosideQ43764668
Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memoryQ44243003
Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formationQ44334398
Environmental enrichment: effects on stereotyped behavior and dendritic morphologyQ44470576
Long-term AICAR administration and exercise prevents diabetes in ZDF ratsQ46406504
PI3 kinase signaling is required for retrieval and extinction of contextual memoryQ46529350
Contrasting effects of motor and visual spatial learning tasks on dendritic arborization and spine density in ratsQ46544908
Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.Q46843627
Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.Q46843629
Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance?Q46919268
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos diseaseQ47198015
Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signalingQ48177303
Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn.Q51471758
Generation of shRNA transgenic mice.Q51939316
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.Q52000260
PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.Q52545721
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampusQ59085769
P433issue3
P921main subjectknockout mouseQ1364740
P304page(s)228-239
P577publication date2011-06-07
P1433published inInternational journal of biochemistry and molecular biologyQ27723022
P1476titleWhat we have learnt about PIKE from the knockout mice
P478volume2

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