AMPK exerts dual regulatory effects on the PI3K pathway.

scientific article published on 18 February 2010

AMPK exerts dual regulatory effects on the PI3K pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/1750-2187-5-1
P932PMC publication ID2848036
P698PubMed publication ID20167101
P5875ResearchGate publication ID41485756

P50authorMengwei ZangQ39942539
P2093author name stringWen Guo
Jun Gong
Rong Wen
Rong Tao
Zhijun Luo
Xixi Luo
P2860cites workAgonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathwayQ53551231
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in miceQ60677521
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in manQ79848490
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationQ24535576
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growthQ28262401
Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathwayQ28271322
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytesQ33401473
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinaseQ33965444
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.Q35103810
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cellsQ35218922
Restraining PI3K: mTOR signalling goes back to the membrane.Q36011048
AMPK, the metabolic syndrome and cancerQ36024356
Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.Q36461897
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.Q36497296
AMP-activated protein kinase as a drug target.Q36551887
Interaction between the AMP-activated protein kinase and mTOR signaling pathwaysQ36649629
Expanding mTOR signalingQ36902840
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.Q39863992
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.Q40140985
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.Q40480010
Development of a novel trans-lentiviral vector that affords predictable safetyQ40867960
Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice.Q42516714
The activation of specific gene transcription in the adipose conversion of 3T3 cellsQ42814452
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.Q42818069
AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liverQ43154689
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide ribosideQ43764668
In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodentsQ43990161
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat musclesQ44258939
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heartQ44532391
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activityQ46606786
Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.Q46800417
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.Q46952844
Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.Q48300488
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P304page(s)1
P577publication date2010-02-18
P1433published inJournal of Molecular SignalingQ15756114
P1476titleAMPK exerts dual regulatory effects on the PI3K pathway
P478volume5

Reverse relations

cites work (P2860)
Q3480097611β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue
Q470943656-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway
Q55043236AICAR enhances insulin signaling via downregulation of miR-29.
Q39574716AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake
Q43091920AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.
Q38998413AMPK and Cancer
Q92666563AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
Q43207073AMPK-friend or foe for targeted therapy?
Q35630180Adenosine Monophosphate-activated Protein Kinase Regulates Interleukin-1β Expression and Glial Glutamate Transporter Function in Rodents with Neuropathic Pain
Q58705752Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
Q39326170Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-κB in C2C12 myotubes.
Q37039023CYP1A1 Regulates Breast Cancer Proliferation and Survival
Q39617619Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway.
Q48174460Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK.
Q43147173Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes
Q37799371Effects of Oxygen on Growth and Size: Synthesis of Molecular, Organismal, and Evolutionary Studies with Drosophila melanogaster
Q28084310Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential
Q37184824Expression-based GWAS identifies variants, gene interactions and key regulators affecting intramuscular fatty acid content and composition in porcine meat
Q42292926Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus.
Q54486996Genistein promotes insulin action through adenosine monophosphate–activated protein kinase activation and p70 ribosomal protein S6 kinase 1 inhibition in the skeletal muscle of mice fed a high energy diet
Q64251661Influenza Virus Infections and Cellular Kinases
Q47135810Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
Q38289532Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics
Q44926222Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis
Q38625051Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory
Q36645527MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma
Q38921302Molecular mechanism of hepatic steatosis: pathophysiological role of autophagy
Q36734036New players for advanced prostate cancer and the rationalisation of insulin-sensitising medication
Q42516112Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes
Q92153225PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis
Q39425898Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK
Q39014996Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance
Q33560337ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Q94452875Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway
Q37448089Regulation of metformin response by breast cancer associated gene 2.
Q33637161Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer
Q64102728Role of Modified Atmosphere in Pest Control and Mechanism of Its Effect on Insects
Q92322145SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling
Q37512959Schisandra chinensis prevents alcohol-induced fatty liver disease in rats
Q92444736Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Q35781311Targeting AMPK for cancer prevention and treatment
Q92504214The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials
Q35882782The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
Q91962615The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
Q38165133The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all?
Q34451866Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges
Q37946372What we have learnt about PIKE from the knockout mice

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