| scholarly article | Q13442814 |
| P50 | author | Konstantin Kandror | Q56542795 |
| P2093 | author name string | Alexandros Tzatsos | |
| P2860 | cites work | Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes | Q22241283 |
| Role of AMP-activated protein kinase in mechanism of metformin action | Q22241898 | ||
| Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells | Q24291346 | ||
| Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex | Q24295120 | ||
| Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton | Q24299873 | ||
| mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery | Q24302549 | ||
| Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action | Q24302566 | ||
| Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive | Q24306328 | ||
| LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | Q24310603 | ||
| Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control | Q24314363 | ||
| Phosphorylation and activation of p70s6k by PDK1 | Q24323433 | ||
| The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity | Q24554361 | ||
| Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity | Q24563018 | ||
| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress | Q24633606 | ||
| Dual requirement for a newly identified phosphorylation site in p70s6k | Q24644595 | ||
| Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling | Q24672005 | ||
| RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 | Q24682697 | ||
| TSC2 mediates cellular energy response to control cell growth and survival | Q27860970 | ||
| TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 | ||
| Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro | Q28138191 | ||
| TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function | Q28204144 | ||
| LKB1--a master tumour suppressor of the small intestine and beyond | Q28208312 | ||
| Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome | Q41022988 | ||
| Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway | Q41616329 | ||
| Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes | Q42441787 | ||
| Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells | Q42804994 | ||
| Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. | Q42805782 | ||
| Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. | Q42822916 | ||
| Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. | Q42829442 | ||
| Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation | Q43833571 | ||
| In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites | Q44889271 | ||
| Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies | Q45067792 | ||
| Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies | Q47954202 | ||
| Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. | Q54069188 | ||
| Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy | Q54332121 | ||
| Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians | Q54383566 | ||
| Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site | Q28210107 | ||
| The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif | Q28211968 | ||
| The AMP-activated protein kinase cascade--a unifying system for energy control | Q28239257 | ||
| Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site | Q28243447 | ||
| Rheb binds and regulates the mTOR kinase | Q28247033 | ||
| Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency | Q28249019 | ||
| Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function | Q28254826 | ||
| The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus | Q28257161 | ||
| The LKB1 tumor suppressor negatively regulates mTOR signaling | Q28272728 | ||
| Upstream and downstream of mTOR | Q28277365 | ||
| SKAR is a specific target of S6 kinase 1 in cell growth control | Q28280086 | ||
| Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4 | Q28343432 | ||
| Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes | Q28369463 | ||
| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins | Q28507365 | ||
| The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity | Q29547190 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| Cellular mechanisms of insulin resistance | Q29619549 | ||
| Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin | Q29620399 | ||
| Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation | Q31855649 | ||
| Structural and functional analysis of pp70S6k | Q33716466 | ||
| Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction | Q33841869 | ||
| Rheb promotes cell growth as a component of the insulin/TOR signalling network | Q34199893 | ||
| Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation | Q34254516 | ||
| Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. | Q34420922 | ||
| Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts | Q34686842 | ||
| Metabolic effects of metformin in non-insulin-dependent diabetes mellitus | Q34720764 | ||
| A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. | Q35285121 | ||
| Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus | Q36111074 | ||
| YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites | Q36561273 | ||
| Bidirectional modulation of insulin action by amino acids | Q37380395 | ||
| Multiple independent inputs are required for activation of the p70 S6 kinase | Q38295925 | ||
| Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. | Q38340048 | ||
| The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases | Q40020238 | ||
| Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo | Q40626700 | ||
| Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity | Q40721919 | ||
| Identification of a conserved motif required for mTOR signaling | Q40736711 | ||
| Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells | Q40787082 | ||
| Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates. | Q40993000 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| phosphorylation | Q242736 | ||
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 63-76 | |
| P577 | publication date | 2006-01-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation | |
| P478 | volume | 26 |
| Q35837163 | 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL |
| Q37251400 | A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. |
| Q45794471 | A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin |
| Q41889379 | A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| Q39255027 | AKT/PKB Signaling: Navigating the Network |
| Q35103810 | AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. |
| Q43154689 | AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver |
| Q39861564 | AMPK exerts dual regulatory effects on the PI3K pathway. |
| Q37086421 | APPL1: role in adiponectin signaling and beyond |
| Q36749704 | Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats |
| Q34080562 | Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo |
| Q55071571 | Acute rapamycin treatment improved glucose tolerance through inhibition of hepatic gluconeogenesis in rainbow trout (Oncorhynchus mykiss). |
| Q36618951 | Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer |
| Q36614145 | Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions |
| Q37801565 | Aging and TOR: interwoven in the fabric of life |
| Q88800358 | Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation |
| Q37162256 | Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes |
| Q41644777 | Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. |
| Q35838909 | Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. |
| Q34800387 | An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism |
| Q38454084 | Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition |
| Q47408853 | Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. |
| Q89909412 | Atorvastatin promotes AMPK signaling to protect against high fat diet-induced non-alcoholic fatty liver in golden hamsters |
| Q36047022 | Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice. |
| Q37529825 | Autophagy: regulation and role in disease |
| Q34766166 | Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of rapamycin signaling |
| Q35829203 | Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns |
| Q24645183 | Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1 |
| Q37284301 | Chemopreventive effects of metformin on obesity-associated endometrial proliferation |
| Q34102206 | Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes |
| Q36147346 | Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats |
| Q40693029 | Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue |
| Q34894537 | Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum |
| Q34977124 | Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma |
| Q28477922 | Computational modeling and analysis of insulin induced eukaryotic translation initiation |
| Q37997206 | Connecting mTORC1 signaling to SREBP-1 activation |
| Q39186250 | Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer |
| Q34049893 | Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation |
| Q37953476 | Current development of the second generation of mTOR inhibitors as anticancer agents |
| Q89087700 | DEPTOR at the Nexus of Cancer, Metabolism, and Immunity |
| Q34293348 | DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. |
| Q37355543 | Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors |
| Q42166312 | Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. |
| Q34600369 | Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells |
| Q36402424 | Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells |
| Q40245739 | Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. |
| Q53341441 | Downhill Running Excessive Training Inhibits Hypertrophy in Mice Skeletal Muscles with Different Fiber Type Composition. |
| Q33619056 | Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling |
| Q53342336 | Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. |
| Q54359878 | Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats |
| Q28511429 | Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 |
| Q35579562 | Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State |
| Q34974398 | Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance. |
| Q24633352 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease |
| Q40140985 | Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. |
| Q35679387 | Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture |
| Q37257933 | Expression and function of the insulin receptor substrate proteins in cancer |
| Q35014198 | Frontier of Epilepsy Research - mTOR signaling pathway |
| Q58695089 | Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating Akt/mTOR Signaling |
| Q37439028 | Global IRS-1 phosphorylation analysis in insulin resistance |
| Q34155468 | Glycolytic inhibition as a strategy for developing calorie restriction mimetics |
| Q39452567 | Heparin-Binding EGF-Like Growth Factor (HB-EGF) Mediates 5-HT-Induced Insulin Resistance Through Activation of EGF Receptor-ERK1/2-mTOR Pathway |
| Q40013894 | Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice |
| Q37179570 | Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. |
| Q48151751 | Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus |
| Q34132583 | IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects |
| Q35945000 | Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance |
| Q37967444 | Immunomodulation at epithelial sites by obesity and metabolic disease |
| Q35757202 | Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle |
| Q48097012 | Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet |
| Q54496176 | Influence of short-term L-arginine supplementation on carbohydrate balance in rats with ischemia-reperfusion syndrome |
| Q47639282 | Inherent aerobic capacity-dependent differences in breast carcinogenesis |
| Q42819114 | Inhibition of the TNF-α^|^ndash;Induced Serine Phosphorylation of IRS-1 at 636/639 by AICAR |
| Q37312198 | Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism. |
| Q33556119 | Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation |
| Q40054024 | Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors |
| Q38079446 | Insulin resistance and the metabolism of branched-chain amino acids |
| Q30417125 | Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet |
| Q36848937 | Insulin sensitivity: modulation by nutrients and inflammation |
| Q29617097 | Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 |
| Q54631286 | Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907 |
| Q36711111 | Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells |
| Q37403996 | Interleukin-6 and insulin resistance |
| Q28071388 | Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives |
| Q35992132 | K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas |
| Q33656497 | Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice |
| Q36292001 | Koschei the immortal and anti-aging drugs |
| Q35336894 | Leucine alters hepatic glucose/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway - potential implications for nonalcoholic fatty liver disease |
| Q29543116 | Leucine signaling in the pathogenesis of type 2 diabetes and obesity |
| Q37015068 | Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation |
| Q35902863 | Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle |
| Q33600500 | Loss of hepatic DEPTOR alters the metabolic transition to fasting |
| Q33918399 | Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma |
| Q40002274 | Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis |
| Q37996733 | Lost in translation: regulation of skeletal muscle protein synthesis |
| Q47236254 | Low Molecular Weight Fucoidan Improves Endoplasmic Reticulum Stress-Reduced Insulin Sensitivity through AMP-Activated Protein Kinase Activation in L6 Myotubes and Restores Lipid Homeostasis in a Mouse Model of Type 2 Diabetes |
| Q37943416 | Mammalian TOR signaling to the AGC kinases |
| Q36481912 | Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis |
| Q38002007 | Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications |
| Q36812444 | Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism |
| Q33750671 | Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage |
| Q37243975 | Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation |
| Q37002663 | Mechanistic target of rapamycin controls homeostasis of adipogenesis |
| Q27687459 | Metabolic benefits of resistance training and fast glycolytic skeletal muscle |
| Q28551227 | Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis |
| Q34554303 | Metformin and sex: Why suppression of aging may be harmful to young male mice |
| Q43206333 | Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells |
| Q55494305 | Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1. |
| Q39707409 | Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner |
| Q92660744 | Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila |
| Q47596109 | Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase |
| Q27009396 | Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle |
| Q60310909 | Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells |
| Q35940231 | Obesity: considerations about etiology, metabolism, and the use of experimental models |
| Q36062176 | Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to |
| Q38611641 | Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance |
| Q27000683 | Over-nutrition and metabolic cardiomyopathy |
| Q99635192 | Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis |
| Q34460797 | PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent |
| Q37500523 | PRAS40: target or modulator of mTORC1 signalling and insulin action? |
| Q53331675 | PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling |
| Q92705363 | Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells |
| Q36139251 | Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo |
| Q58609421 | Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices |
| Q92856776 | Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway |
| Q38806361 | Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice |
| Q42913232 | Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling |
| Q35370616 | Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling |
| Q24315127 | Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells |
| Q36635784 | Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling |
| Q90019233 | Postprandial metabolic responses to ingestion of bovine glycomacropeptide compared to a whey protein isolate in prediabetic volunteers |
| Q38628797 | Potential therapeutic effects of mTOR inhibition in atherosclerosis. |
| Q28583646 | Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage |
| Q35601249 | Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice |
| Q35532243 | Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation |
| Q92369342 | Proteomics insights into the effects of MSTN on muscle glucose and lipid metabolism in genetically edited cattle |
| Q36977162 | Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice. |
| Q35911741 | Rapamycin impairs HPD-induced beneficial effects on glucose homeostasis |
| Q41951665 | Rapamycin induces transactivation of the EGFR and increases cell survival |
| Q30438876 | Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins |
| Q46972339 | Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling |
| Q38997125 | Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium |
| Q35371402 | Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1) |
| Q39832067 | Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR |
| Q37823690 | Re-evaluating the general(ized) roles of AMPK in cellular metabolism |
| Q37221646 | Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival |
| Q38216365 | Regulation of autophagy by amino acids and MTOR-dependent signal transduction |
| Q36939696 | Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2) |
| Q28272571 | Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 |
| Q34342717 | Regulation of mTORC1 and its impact on gene expression at a glance |
| Q34998025 | Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways |
| Q42541479 | Response to Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. Diabetes 2015;64:1555-1563. |
| Q38165106 | Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance |
| Q37034769 | Role of resistin in cardiac contractility and hypertrophy. |
| Q47692117 | SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology |
| Q35846190 | Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. |
| Q91626057 | Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase |
| Q28513222 | Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling |
| Q33904759 | Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial |
| Q38162987 | Signaling pathways controlling skeletal muscle mass |
| Q38866633 | Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. |
| Q33557084 | Successful weight loss surgery improves eating control and energy metabolism: a review of the evidence |
| Q21136155 | Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1 |
| Q37575390 | Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids |
| Q38187197 | Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients |
| Q34391710 | TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists |
| Q37864203 | Targeting Type 2 Diabetes |
| Q28088661 | The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins |
| Q64107904 | The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner |
| Q34828662 | The PTEN-PI3K pathway: of feedbacks and cross-talks |
| Q37821934 | The Role of Protein Kinase R in the Interferon Response |
| Q39451697 | The SCF-Fbxo40 Complex Induces IRS1 Ubiquitination in Skeletal Muscle, Limiting IGF1 Signaling |
| Q36710799 | The TSC1-TSC2 complex is required for proper activation of mTOR complex 2 |
| Q51004205 | The energy sensing LKB1-AMPKα1 pathway regulates IGF1 secretion and consequent activation of the IGF1R-PKB pathway in primary hepatocytes |
| Q38162827 | The importance of autophagy in cardioprotection |
| Q24312951 | The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy |
| Q39297991 | The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. |
| Q39021890 | The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase |
| Q38867790 | The mammalian target of rapamycin signaling pathway regulates myocyte enhancer factor-2C phosphorylation levels through integrin-linked kinase in goat skeletal muscle satellite cells |
| Q84984851 | The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth |
| Q36631664 | The twentieth century struggle to decipher insulin signalling |
| Q24670558 | Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis |
| Q90019779 | Type 2 diabetes - unmet need, unresolved pathogenesis, mTORC1-centric paradigm |
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