| scholarly article | Q13442814 |
| P2093 | author name string | Yuhua Wang | |
| Alessandro Pocai | |||
| Jonathan M Backer | |||
| Tomoichiro Asano | |||
| Gary J Schwartz | |||
| Hideyuki Sakoda | |||
| Hiraku Ono | |||
| Luciano Rossetti | |||
| P2860 | cites work | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action | Q24302566 |
| Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation | Q24535576 | ||
| Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation | Q45230456 | ||
| Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway | Q45251821 | ||
| Regulation of blood glucose by hypothalamic pyruvate metabolism | Q46635921 | ||
| Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. | Q46670120 | ||
| Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes | Q46884440 | ||
| Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production | Q48145978 | ||
| Role of hepatic STAT3 in brain-insulin action on hepatic glucose production | Q48596967 | ||
| Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats. | Q54108239 | ||
| Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes | Q24564844 | ||
| Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis | Q24670558 | ||
| Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis | Q24676203 | ||
| A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling | Q24678327 | ||
| TSC2 mediates cellular energy response to control cell growth and survival | Q27860970 | ||
| The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif | Q28211968 | ||
| Positive and negative regulation of insulin signaling through IRS-1 phosphorylation | Q28236905 | ||
| Hypothalamic mTOR signaling regulates food intake | Q28239714 | ||
| Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase | Q28251762 | ||
| Upstream and downstream of mTOR | Q28277365 | ||
| Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production | Q28566853 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression | Q29617473 | ||
| Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation | Q30453740 | ||
| The role of insulin receptor substrate 2 in hypothalamic and beta cell function. | Q30475796 | ||
| Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome | Q33557797 | ||
| Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila | Q33947844 | ||
| Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. | Q34063643 | ||
| Overfeeding rapidly induces leptin and insulin resistance | Q34103277 | ||
| Hypothalamic K(ATP) channels control hepatic glucose production | Q34413202 | ||
| Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats | Q34435140 | ||
| Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats | Q34975588 | ||
| Signaling pathways: the benefits of good communication | Q35979025 | ||
| Restraining PI3K: mTOR signalling goes back to the membrane. | Q36011048 | ||
| Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. | Q36497296 | ||
| Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? | Q36623657 | ||
| Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase | Q36623662 | ||
| Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo | Q36662772 | ||
| Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus | Q37532741 | ||
| Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice | Q40013894 | ||
| hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase | Q40392574 | ||
| Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. | Q42462295 | ||
| Central administration of oleic acid inhibits glucose production and food intake | Q43867506 | ||
| Hypothalamic insulin signaling is required for inhibition of glucose production | Q44212603 | ||
| Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies | Q45067792 | ||
| Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion | Q45182784 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 2959-2968 | |
| P577 | publication date | 2008-08-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats | |
| P478 | volume | 118 |
| Q41488066 | A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals |
| Q26853447 | A possible link between BDNF and mTOR in control of food intake |
| Q35578609 | Activation of K(ATP) channels suppresses glucose production in humans |
| Q35273863 | Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I |
| Q34227893 | Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome |
| Q34339605 | Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers. |
| Q34701526 | Brain insulin controls adipose tissue lipolysis and lipogenesis |
| Q34624088 | Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. |
| Q30830123 | CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5. |
| Q38095437 | CNS control of glucose metabolism: response to environmental challenges |
| Q37512891 | CNS regulation of glucose homeostasis |
| Q84783911 | Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation |
| Q37014894 | Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve |
| Q34718604 | Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis |
| Q37499206 | Central insulin and leptin-mediated autonomic control of glucose homeostasis. |
| Q38079867 | Central leucine sensing in the control of energy homeostasis |
| Q48635979 | Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve |
| Q35152229 | Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice |
| Q38324690 | Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice. |
| Q41865599 | DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance |
| Q41974156 | Early detection of metabolic and energy disorders by thermal time series stochastic complexity analysis |
| Q90324059 | Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons |
| Q26766494 | Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism |
| Q38007633 | Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production |
| Q37368593 | Evidence for central regulation of glucose metabolism |
| Q48670439 | Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour. |
| Q57298951 | Hypothalamic PDE3B deficiency alters body weight and glucose homeostasis in mouse |
| Q47316523 | Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. |
| Q59361017 | Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis |
| Q37892968 | Hypothalamic control of energy and glucose metabolism |
| Q35318592 | Hypothalamic inflammation: a double-edged sword to nutritional diseases |
| Q36853232 | Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects |
| Q37236339 | Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism |
| Q37070858 | Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis |
| Q39958782 | Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels |
| Q38849153 | Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action |
| Q38130123 | Insulin and glucagon signaling in the central nervous system. |
| Q37954017 | Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? |
| Q36477271 | Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. |
| Q36440547 | Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis |
| Q47837656 | Leptin enhances hypothalamic LDHA-dependent glucose sensing to lower glucose production in high-fat fed rats. |
| Q34072678 | Maternal cigarette smoke exposure contributes to glucose intolerance and decreased brain insulin action in mice offspring independent of maternal diet |
| Q64089054 | Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species |
| Q35405402 | Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats |
| Q41896729 | Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity |
| Q41774358 | Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis |
| Q28731457 | Metabolic control by S6 kinases depends on dietary lipids |
| Q33858514 | Metabolic regulation by protein tyrosine phosphatases |
| Q36637382 | Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance |
| Q64087542 | Molecular Mechanisms of Hypothalamic Insulin Resistance |
| Q36560660 | Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression. |
| Q33640082 | Neuronal control of peripheral insulin sensitivity and glucose metabolism |
| Q42737964 | Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice |
| Q36139251 | Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo |
| Q29347279 | Pim3 negatively regulates glucose-stimulated insulin secretion |
| Q90360189 | Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond |
| Q42702094 | Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. |
| Q39983642 | Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice |
| Q35080060 | Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase |
| Q58794806 | Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet |
| Q40469076 | Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. |
| Q37337607 | Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? |
| Q35561118 | Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice |
| Q37464738 | Targeting the CNS to treat type 2 diabetes |
| Q58798256 | The PI3K/AKT pathway in obesity and type 2 diabetes |
| Q35442466 | The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice |
| Q37282101 | Towards a 'systems'-level understanding of the nervous system and its disorders |
| Q34508419 | Wired on sugar: the role of the CNS in the regulation of glucose homeostasis |
| Q53655923 | [Role of the mTOR pathway in the central regulation of energy balance]. |
| Q37097444 | mTOR couples cellular nutrient sensing to organismal metabolic homeostasis |
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