Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

scientific article

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CMET.2014.09.003
P932PMC publication ID4254305
P698PubMed publication ID25307860
P5875ResearchGate publication ID266731254

P50authorPhillip J. WhiteQ42370049
Wei-Jun QianQ58327364
Christopher B NewgardQ87867408
P2093author name stringRichard D Smith
Jian-Ying Zhou
Olga Ilkayeva
Thomas Scherer
Kevin L Grove
Christopher J Lynch
Andrew C Shin
Uwe Knippschild
Christoph Buettner
Claudia Lindtner
Elizabeth Zielinski
Nika Filatova
Martin Fasshauer
Ludger Scheja
Anna M Wolf
Amanda L Lapworth
Linus A Grundell
P2860cites workMediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuitQ42550972
Insulin effect on leucine kinetics in type 2 diabetes mellitus.Q44098799
Hypothalamic insulin signaling is required for inhibition of glucose productionQ44212603
Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.Q44482073
Insulin acutely increases fibrinogen production in individuals with type 2 diabetes but not in individuals without diabetesQ44493445
Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nervesQ44579245
Selective impairment of insulin signalling in the hypothalamus of obese Zucker ratsQ44644463
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasisQ45286060
Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathyQ46722537
A molecular model of human branched-chain amino acid metabolismQ46762438
Role of brain insulin receptor in control of body weight and reproductionQ47229086
Obese men respond to cognitive but not to catabolic brain insulin signaling.Q50888528
Plasma Amino Acid Levels and Insulin Secretion in ObesityQ51685623
Insulin insensitivity is rapidly reversed in rats by reducing dietary fat from 40 to 30% of energy.Q54262430
Different sensitivity of glucose and amino acid metabolism to insulin in NIDDMQ72616560
Spectrophotometric assay for measuring branched-chain amino acidsQ74318093
Modulation of branched-chain amino acid oxidation in rat hemidiaphragms in vitro by glucose and ketone bodiesQ93644092
Leptin therapy in insulin-deficient type I diabetesQ24620780
A C. elegans mutant that lives twice as long as wild typeQ27861054
Hypothalamic mTOR signaling regulates food intakeQ28239714
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistanceQ28240815
Branched-chain amino acid metabolismQ28267237
Metabolite profiles and the risk of developing diabetesQ29615359
Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetesQ30982692
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profilingQ33325905
Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS).Q33609006
Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemiaQ34082873
Disordered lipid metabolism and the pathogenesis of insulin resistanceQ34370965
Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinaseQ34377914
Hypothalamic K(ATP) channels control hepatic glucose productionQ34413202
Do men develop type 2 diabetes at lower body mass indices than women?Q34454220
Consumption of a high-fat diet induces central insulin resistance independent of adiposityQ34669531
Brain insulin controls adipose tissue lipolysis and lipogenesisQ34701526
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic studyQ35033208
Branched-chain [corrected] amino acid metabolism: implications for establishing safe intakesQ36147749
Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysisQ36294800
Central insulin action regulates peripheral glucose and fat metabolism in miceQ36597490
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adultsQ36629460
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in ratsQ36749704
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight lossQ36851000
Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism.Q37001180
Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian menQ37120388
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanismsQ37165803
Hypothalamic control of hepatic glucose production and its potential role in insulin resistanceQ37332394
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.Q37399240
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.Q37699221
Gender difference in regulation of branched-chain amino acid catabolismQ41816685
The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomicsQ41926369
P433issue5
P921main subjectpreproinsulinQ7240673
P304page(s)898-909
P577publication date2014-10-09
P1433published inCell MetabolismQ1254684
P1476titleBrain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism
P478volume20

Reverse relations

cites work (P2860)
Q50084091A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk.
Q55287185Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes.
Q89412030Amino acids - lifesaver or killer in patients with diabetes?
Q61817179Associations Between Dietary Protein Sources, Plasma BCAA and Short-Chain Acylcarnitine Levels in Adults
Q92432449BRANCHED CHAIN AMINO ACIDS AT THE EDGE BETWEEN MENDELIAN AND COMPLEX DISORDERS
Q47835103Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Q27342729Branched-chain amino acid catabolism is a conserved regulator of physiological ageing
Q29306550Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export
Q28249276Branched-chain amino acids in metabolic signalling and insulin resistance
Q47987782Chronic Diseases and Lifestyle Biomarkers Identification by Metabolomics.
Q47413915Chronic Intranasal Insulin Does Not Affect Hepatic Lipids but Lowers Circulating BCAAs in Healthy Male Subjects.
Q37278842Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism
Q41007154Effect of acute ozone exposure on the lung metabolomes of obese and lean mice
Q89674018Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Q90339347Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
Q57452396Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues
Q64120953Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation
Q36206751Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Q36237292Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover
Q34534015Human gut microbes impact host serum metabolome and insulin sensitivity
Q64259260Impaired Skeletal Muscle Branched-Chain Amino Acids Catabolism Contributes to Their Increased Circulating Levels in a Non-Obese Insulin-Resistant Fructose-Fed Rat Model
Q39958782Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels
Q38849153Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
Q92309048Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
Q51835057Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs.
Q90036390Metabolic fingerprint of insulin resistance in human polymorphonuclear leucocytes
Q35658650Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes
Q57107268Metabolites as regulators of insulin sensitivity and metabolism
Q92219580NMR-Based Metabolomic Approach Tracks Potential Serum Biomarkers of Disease Progression in Patients with Type 2 Diabetes Mellitus
Q36245518NMR-based metabolic profiling in healthy individuals overfed different types of fat: links to changes in liver fat accumulation and lean tissue mass
Q51249812Plasma Amino Acids vs Conventional Predictors of Insulin Resistance Measured by the Hyperinsulinemic Clamp.
Q93200099Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Q90360189Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond
Q64122235SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
Q47312518Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes
Q54108559The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
Q26744725The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
Q28069578The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review
Q92493549The pattern of plasma BCAA concentration and liver Bckdha gene expression in GK rats during T2D progression
Q37125652The positive association of branched-chain amino acids and metabolic dyslipidemia in Chinese Han population
Q92051151Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform
Q90289606Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys
Q35856483Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders
Q50084039Using Metabolomics to Explore the Role of Postmenopausal Adiposity in Breast Cancer Risk.
Q38851257What Have Metabolomics Approaches Taught Us About Type 2 Diabetes?

Search more.