| P50 | author | David M. Holtzman | Q56827171 |
| | Steven E. Arnold | Q64157128 |
| | Hoau-Yan Wang | Q90191543 |
| | Zoe Arvanitakis | Q96585161 |
| | Suzanne Craft | Q114385410 |
| P2093 | author name string | Sam Gandy | |
| | David M Nathan | |
| | Luke E Stoeckel | |
| | Rexford S Ahima | |
| | Aaron M Koenig | |
| | Christoph Buettner | |
| | Shannon L Macauley-Rambach | |
| P2860 | cites work | Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice. | Q46396191 |
| | A biochemical and functional characterization of diet-induced brain insulin resistance | Q46526769 |
| | Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus | Q46530266 |
| | Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype | Q46553973 |
| | Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner | Q46644037 |
| | Beta-amyloid deposition in brains of subjects with diabetes | Q46697376 |
| | High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity | Q21131756 |
| | Neocortical glial cell numbers in human brains | Q22337338 |
| | Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction | Q26745936 |
| | Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models | Q26750648 |
| | Insulin in the brain: there and back again | Q26825385 |
| | Vascular contributions to cognitive impairment and dementia including Alzheimer's disease | Q26852882 |
| | Alzheimer's disease and insulin resistance: translating basic science into clinical applications | Q26996487 |
| | Energy metabolism in the liver | Q26996783 |
| | Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease | Q27021700 |
| | The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier? | Q27307127 |
| | Neuropathology of type 2 diabetes: a short review on insulin-related mechanisms | Q27694676 |
| | The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses | Q28142887 |
| | Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain | Q28267027 |
| | LTP inhibits LTD in the hippocampus via regulation of GSK3beta | Q28290606 |
| | Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview | Q28386522 |
| | Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity | Q28394667 |
| | Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane | Q28507956 |
| | Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling | Q28574687 |
| | ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53 | Q28579738 |
| | Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death | Q28580812 |
| | Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways | Q28581081 |
| | Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? | Q29619535 |
| | Obesity and metabolic syndrome and functional and structural brain impairments in adolescence | Q36277618 |
| | Risk of dementia in diabetes mellitus: a systematic review | Q36345254 |
| | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI. | Q36359185 |
| | Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study | Q36379186 |
| | White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome | Q36431622 |
| | Glucose improves object-location binding in visual-spatial working memory | Q36456357 |
| | Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia | Q36490441 |
| | Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease | Q36493730 |
| | Diabetes mellitus, dementia, and cognitive function in older persons. | Q36555718 |
| | Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults | Q36560342 |
| | Insulin signaling in the central nervous system: learning to survive | Q36568898 |
| | Changes in glycemic control are associated with changes in cognition in non-diabetic elderly | Q36651075 |
| | Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits | Q36651084 |
| | Diabetes is associated with postural instability and gait difficulty in Parkinson disease | Q36715663 |
| | Memory dysfunction in type 2 diabetes mellitus correlates with reduced hippocampal CA1 and subiculum volumes | Q36811646 |
| | Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease | Q36906241 |
| | Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation. | Q36916183 |
| | Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture | Q36930826 |
| | Depression and type 2 diabetes over the lifespan: a meta-analysis | Q36975746 |
| | The GSK3 hypothesis of Alzheimer's disease | Q37035378 |
| | Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus. | Q37075802 |
| | Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia | Q37118453 |
| | Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair | Q37134778 |
| | Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology | Q37178970 |
| | Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence? | Q37179048 |
| | Cognition in the early stage of type 2 diabetes | Q37235965 |
| | Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years | Q37261182 |
| | Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. | Q37270145 |
| | Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial | Q37364862 |
| | Different patterns of cerebral injury in dementia with or without diabetes | Q37397970 |
| | Regulation of insulin secretion: a matter of phase control and amplitude modulation | Q37415411 |
| | Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. | Q37445092 |
| | Impaired glycemia increases disease progression in mild cognitive impairment | Q37489320 |
| | Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus. | Q37513659 |
| | Clinical and biomarker changes in dominantly inherited Alzheimer's disease | Q29619940 |
| | Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task | Q30305450 |
| | Glucose levels and risk of dementia | Q30574095 |
| | Brain imaging in type 2 diabetes | Q30799335 |
| | Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial | Q30847247 |
| | Is type 2 diabetes related to leukoaraiosis? an updated review | Q30910261 |
| | Brain imaging in patients with diabetes: a systematic review | Q31070335 |
| | Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction | Q31135422 |
| | Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. | Q32050146 |
| | Central nervous system effects of intranasally administered insulin during euglycemia in men. | Q33177645 |
| | Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation | Q33573761 |
| | Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application | Q33593963 |
| | Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies | Q33607787 |
| | Type 2 diabetes mellitus, cognitive impairment and dementia. | Q33608617 |
| | Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology? | Q33625557 |
| | Human cerebral neuropathology of Type 2 diabetes mellitus | Q33710643 |
| | Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects. | Q33750654 |
| | Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease | Q33789329 |
| | Cardiovascular risk factors and frontotemporal dementia: a case-control study | Q33841997 |
| | High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice | Q33850466 |
| | Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain | Q33904901 |
| | Increased Alzheimer's disease neuropathology is associated with type 2 diabetes and ApoE ε.4 carrier status | Q33927061 |
| | Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease | Q33940256 |
| | Insulin promotes glycogen storage and cell proliferation in primary human astrocytes | Q33955102 |
| | Toward a comprehensive neurobiology of IGF-I. | Q34100780 |
| | Recommendations of the Alzheimer's disease-related dementias conference | Q34135726 |
| | Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport | Q34204881 |
| | Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study | Q34237709 |
| | Brain glucose transporters: relationship to local energy demand. | Q34272623 |
| | Hyperinsulinemia drives diet-induced obesity independently of brain insulin production | Q34315893 |
| | Intranasal insulin improves memory in humans | Q34337964 |
| | Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes | Q34375958 |
| | Hypothalamic K(ATP) channels control hepatic glucose production | Q34413202 |
| | Alzheimer's disease risk genes and mechanisms of disease pathogenesis | Q34425904 |
| | Increased feeding in response to bilateral injection of insulin antibodies in the VMH | Q43497835 |
| | Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study | Q43570563 |
| | Glucose tolerance status and risk of dementia in the community: the Hisayama study | Q43584777 |
| | Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study | Q43653450 |
| | Acute third ventricular administration of insulin decreases food intake in two paradigms | Q43921743 |
| | Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study | Q43935519 |
| | Diabetes, impaired fasting glucose, and development of cognitive impairment in older women | Q43959470 |
| | Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats | Q44001034 |
| | Insulin modulates food-related activity in the central nervous system | Q44116251 |
| | Hypothalamic insulin signaling is required for inhibition of glucose production | Q44212603 |
| | Diabetes as a predictor of change in functional status among older Mexican Americans: a population-based cohort study | Q44291177 |
| | Role of protein kinase B in Alzheimer's neurofibrillary pathology | Q44354353 |
| | The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging | Q44453020 |
| | Mid-life and late-life vascular risk factors and dementia in Korean men and women. | Q44658306 |
| | Evidence for altered transport of insulin across the blood-brain barrier in insulin-resistant humans | Q44691083 |
| | Akt activity in Alzheimer's disease and other neurodegenerative disorders | Q44838986 |
| | Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain | Q45032333 |
| | The metabolic syndrome, inflammation, and risk of cognitive decline | Q45145786 |
| | Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes. | Q45232246 |
| | Impact of diabetes on cognitive function among older Latinos: a population-based cohort study | Q46075641 |
| | Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology | Q46386533 |
| | The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. | Q52013227 |
| | Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus: a population-based cohort study. | Q52013711 |
| | Type 2 diabetes and cognitive function in community-dwelling elderly women. | Q52134906 |
| | Decreased cognitive function in aging non-insulin-dependent diabetic patients. | Q52209256 |
| | Insulin II gene expression in rat central nervous system. | Q52222302 |
| | Type 2 diabetes and the risk of Parkinson's disease. | Q53016612 |
| | Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort. | Q53098272 |
| | Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. | Q53220314 |
| | Diabetes mellitus and the risk of dementia: The Rotterdam Study. | Q53231897 |
| | Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer's disease: a population-based study of the oldest old. | Q53355969 |
| | Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes? | Q56049682 |
| | Response of human oligodendrocyte progenitors to growth factors and axon signals | Q57041505 |
| | Genetics of Alzheimer’s Disease | Q57393344 |
| | Glucose Levels and Risk of Dementia | Q57417686 |
| | Diabetes and risk of Parkinson's disease | Q57786182 |
| | Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man | Q68917275 |
| | Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type | Q69966121 |
| | Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin | Q73929830 |
| | Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter | Q74339132 |
| | Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging | Q74530815 |
| | Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans | Q81400158 |
| | Localization and Characterization of Insulin-Like Growth Factor-I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry* A Distinct Distribution from Insulin Receptors | Q83330616 |
| | Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies | Q84140005 |
| | Long Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia | Q87108189 |
| | Brain glucose transporters: implications for neurologic disease | Q87474428 |
| | Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans | Q37554749 |
| | Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging | Q37603091 |
| | Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer's Disease | Q37613304 |
| | Mini-review: impact of recurrent hypoglycemia on cognitive and brain function | Q37680217 |
| | Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors. | Q37737294 |
| | Insulin, synaptic function, and opportunities for neuroprotection | Q37825696 |
| | Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship | Q38073603 |
| | New animal models of Alzheimer's disease that display insulin desensitization in the brain | Q38164626 |
| | Glucose transport in brain - effect of inflammation | Q38187686 |
| | Insulin and insulin-like growth factor receptors in the nervous system | Q38296571 |
| | Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions | Q38325652 |
| | Localization of insulin receptor mRNA in rat brain by in situ hybridization | Q38337976 |
| | Cognitive dysfunctions in middle-aged type 2 diabetic patients and neuroimaging correlations: a cross-sectional study | Q38426860 |
| | Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine | Q38614803 |
| | The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity | Q38796469 |
| | Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells | Q38854994 |
| | Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders | Q38924913 |
| | Mechanisms of β-cell functional adaptation to changes in workload | Q38951163 |
| | The neuronal insulin receptor in its environment | Q39021127 |
| | Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study | Q39399317 |
| | Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons | Q39695680 |
| | Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels | Q39958782 |
| | Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology | Q40059968 |
| | The Role of Insulin as a Satiety Factor in the Central Nervous System | Q40169524 |
| | Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study | Q40316491 |
| | Glucose intolerance and aging | Q40336123 |
| | Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt). | Q40469403 |
| | HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation | Q40511072 |
| | Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study | Q40638812 |
| | The relationship between diabetes mellitus and Parkinson's disease | Q40701172 |
| | Age as independent determinant of glucose tolerance | Q41181985 |
| | Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent | Q41199768 |
| | Relationship between hyperglycemia and cognitive function in older NIDDM patients | Q41203245 |
| | Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies | Q41364742 |
| | Type 2 diabetes mellitus and biomarkers of neurodegeneration | Q41531923 |
| | Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. | Q41841220 |
| | Human blood-brain barrier insulin receptor | Q42001778 |
| | Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain | Q42476750 |
| | Impaired fasting glucose is associated with increased regional cerebral amyloid | Q42630472 |
| | Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes | Q42652385 |
| | Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats | Q42808284 |
| | Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study | Q42925712 |
| | Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. | Q42933731 |
| | Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. | Q42939448 |
| | Akt signal transduction dysfunction in Parkinson's disease | Q43267759 |
| | Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. | Q46778500 |
| | Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin | Q46784330 |
| | Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3. | Q46842862 |
| | Glucose transport in primary cultured neurons | Q46903557 |
| | Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. | Q47408299 |
| | Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. | Q48046400 |
| | Insulin gene expression and insulin synthesis in mammalian neuronal cells | Q48084097 |
| | Cerebrospinal fluid insulin during non-neurological surgery | Q48094566 |
| | Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry | Q48199037 |
| | Relation of diabetes to mild cognitive impairment | Q48210463 |
| | Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease | Q48216036 |
| | Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes | Q48255137 |
| | Insulin is released from rat brain neuronal cells in culture | Q48305708 |
| | Periventricular hypothalamic cells in the rat brain contain insulin mRNA. | Q48316161 |
| | Diabetes is related to cerebral infarction but not to AD pathology in older persons | Q48342090 |
| | Insulin receptors and signal transduction proteins in the hypothalamo-hypophyseal system: a review on morphological findings and functional implications | Q48353577 |
| | Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle | Q48371514 |
| | Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies | Q48382511 |
| | Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome? | Q48387577 |
| | Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease | Q48404181 |
| | Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis | Q48404189 |
| | Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats | Q48422314 |
| | Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis | Q48440141 |
| | Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation | Q48449649 |
| | Developmental regulation of insulin in the mammalian central nervous system | Q48469988 |
| | Central insulin administration improves odor-cued reactivation of spatial memory in young men. | Q48477959 |
| | Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues | Q48486325 |
| | Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes | Q48558337 |
| | Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination | Q48558847 |
| | Short-term influence of intra-ventromedial hypothalamic administration of insulin on feeding in normal and diabetic rats | Q48573538 |
| | Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes | Q48603149 |
| | Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain | Q48613466 |
| | Intracranial vascular lesions in patients with diabetes mellitus | Q48669178 |
| | Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice | Q48677086 |
| | Dementia is associated with insulin resistance in patients with Parkinson's disease | Q48748538 |
| | A direct action of insulin on the hypothalamic satiety center | Q48892698 |
| | Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues | Q48947046 |
| | The binding of insulin to cerebral capillaries and astrocytes of the rat. | Q48959931 |
| | Effects of insulin administered into cerebrospinal fluid spaces on blood glucose in unanaesthetized and anaesthetized dogs. | Q48959941 |
| | C-peptide immunoreactive neurons in human brain | Q49091009 |
| | Insulin receptor mRNA in the substantia nigra in Parkinson's disease | Q49118575 |
| | Obese men respond to cognitive but not to catabolic brain insulin signaling. | Q50888528 |
| | Clinical features of Parkinson disease when onset of diabetes came first: A case-control study. | Q50948858 |
| | Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). | Q51028523 |
| | Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation. | Q51336540 |
| | SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse. | Q51473388 |
| | Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype. | Q51556224 |
| | Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. | Q51648669 |
| | Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases. | Q51713596 |
| | Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment. | Q51877729 |
| | Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease | Q36023835 |
| | Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo | Q36059091 |
| | Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease | Q36062457 |
| | Recent advances in understanding the genetic architecture of type 2 diabetes | Q36065329 |
| | Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging | Q36078724 |
| | Resting-state brain functional connectivity is altered in type 2 diabetes | Q36182522 |
| | Insulin resistance predicts brain amyloid deposition in late middle-aged adults. | Q34429975 |
| | Insulin modulation of magnetoencephalographic resting state dynamics in lean and obese subjects | Q34443543 |
| | Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study | Q34458197 |
| | Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers | Q34468797 |
| | Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine | Q34474707 |
| | Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. | Q34624088 |
| | Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo | Q34674963 |
| | Brain insulin controls adipose tissue lipolysis and lipogenesis | Q34701526 |
| | Diabetes and risk of Parkinson's disease | Q34718429 |
| | Insulin resistance as the core defect in type 2 diabetes mellitus | Q34856847 |
| | Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study | Q34866029 |
| | Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies | Q35006687 |
| | The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study | Q35033208 |
| | Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus | Q35049804 |
| | Insulin and the blood-brain barrier | Q35100984 |
| | Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes | Q35114494 |
| | Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study | Q35123326 |
| | The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. | Q35304821 |
| | Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging | Q35470433 |
| | Insulin in the brain: a hormonal regulator of energy balance | Q35486553 |
| | Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test | Q35563398 |
| | Insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease | Q35630843 |
| | Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial | Q35679839 |
| | Disrupted resting-state attentional networks in T2DM patients | Q35693415 |
| | Glucose indices are associated with cognitive and structural brain measures in young adults | Q35730940 |
| | Type 2 diabetes affects hippocampus volume differentially in men and women. | Q35740688 |
| | Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex | Q35743094 |
| | The source of cerebral insulin | Q35749604 |
| | Glucose transporter expression in the central nervous system: relationship to synaptic function | Q35749608 |
| | An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers | Q35858008 |
| | Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline | Q35858095 |
| | Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly | Q35879058 |
| | Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. | Q35898211 |
| | Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors | Q35986995 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| | type 2 diabetes | Q3025883 |
| | Alzheimer's disease | Q11081 |
| P577 | publication date | 2018-01-29 | |
| P1433 | published in | Nature Reviews Neurology | Q2079285 |
| P1476 | title | Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums | |