Immunomodulation at epithelial sites by obesity and metabolic disease

scientific article published on June 2012

Immunomodulation at epithelial sites by obesity and metabolic disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12026-011-8261-7
P698PubMed publication ID22160809

P2093author name stringJulie M Jameson
Kristen R Taylor
Kitty P Cheung
P2860cites workMHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathyQ77332300
A role for skin gammadelta T cells in wound repairQ78009443
Role of gamma delta T cells in the inflammatory response of experimental colitis miceQ79274267
Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infectionQ79789978
A key role of leptin in the control of regulatory T cell proliferationQ79792939
Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-alpha antibody infliximab: a case observationQ79793046
Sirolimus impairs wound healingQ80035894
Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancerQ80527598
Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximabQ80590261
IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injuryQ80865431
Inflammation as a sensor of metabolic stress in obesity and type 2 diabetesQ82158831
Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillanceQ82878964
The impact of increased body mass index on the clinical course of Crohn's diseaseQ83157629
Dynamics of non-conventional intraepithelial lymphocytes-NK, NKT, and γδ T-in celiac disease: relationship with age, diet, and histopathologyQ83164356
Association between obesity and atopic dermatitis in childhood: a case-control studyQ83630576
Obesity is a determinant of asthma control independent of inflammation and lung mechanicsQ83638489
Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in miceQ83918279
Toll-like receptor expression and function in subsets of human gammadelta T lymphocytesQ84456947
Association between atopic dermatitis and obesity in adulthoodQ85097143
The impact of obesity on skin disease and epidermal permeability barrier statusQ94946508
Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in miceQ21090039
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICAQ22010440
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cellsQ24316370
Obesity alters gut microbial ecologyQ24531503
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationQ24535576
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptorsQ24629394
mTOR: from growth signal integration to cancer, diabetes and ageingQ24633662
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic diseaseQ27324312
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populationsQ28142106
Regulation of cutaneous malignancy by gammadelta T cellsQ28188439
Obesity and infectionQ28247492
Immunosurveillance and immunoregulation by gammadelta T cellsQ28292156
Diversity, rearrangement, and expression of murine T cell gamma genesQ28299047
Epidermal T cells and wound healingQ28383586
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppressionQ28594263
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
IKK-beta links inflammation to obesity-induced insulin resistanceQ29614285
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in miceQ29615055
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha functionQ29616104
Type 2 diabetes as an inflammatory diseaseQ29617184
Serum immunoreactive-leptin concentrations in normal-weight and obese humansQ29617230
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
Interleukin-1-receptor antagonist in type 2 diabetes mellitusQ29619001
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBQ29619314
Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes.Q64964865
Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expressionQ69924679
Spontaneous development of inflammatory bowel disease in T cell receptor mutant miceQ72233696
Defective T cell receptor/CD3 complex signaling in human type I diabetesQ72345250
Impaired immunity in obesity: suppressed but reversible lymphocyte responsivenessQ72707020
Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexiaQ73134698
A population of murine gammadelta T cells that recognize an inducible MHC class Ib moleculeQ73352533
Flexible migration program regulates gamma delta T-cell involvement in humoral immunityQ73708692
Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injuryQ73792750
IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigensQ74515359
Requirement for gammadelta T cells in allergic airway inflammationQ74576772
Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent SurvivalQ36549632
gammadelta T cells: firefighters or fire boosters in the front lines of inflammatory responsesQ36732670
T-cell activation in the intestinal mucosaQ36732698
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistanceQ36793320
Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsivenessQ36804892
Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated miceQ36899362
The interplay of obesity and asthmaQ36909691
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.Q36995837
mTOR couples cellular nutrient sensing to organismal metabolic homeostasisQ37097444
Obesity and asthma: possible mechanismsQ37135954
Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetesQ37143485
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survivalQ37199519
A role for human skin-resident T cells in wound healingQ37273275
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.Q37319117
T cell dependence on mTOR signalingQ37381564
Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injuryQ37391313
Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosisQ37396937
Obesity accelerates thymic agingQ37412361
Obesity promotes melanoma tumor growth: role of leptinQ37485917
The major inflammatory mediator interleukin-6 and obesityQ37526512
Gammadelta T cell effector functions: a blend of innate programming and acquired plasticityQ37764294
IL-6: regulator of Treg/Th17 balanceQ37768101
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolismQ37792556
Fatty acid-gene interactions, adipokines and obesity.Q37827688
A clinical perspective of IL-1β as the gatekeeper of inflammationQ37869439
Management of type 2 diabetes: new and future developments in treatmentQ37894446
Wound healing in the patient with diabetes mellitusQ37907639
Asthma and obesity: a known association but unknown mechanismQ37944900
Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.Q38298503
Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitisQ38308819
Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db miceQ38310497
Weight-dependent changes of immune system in adipose tissue: importance of leptin.Q38313751
Leptin deficiency enhances sensitivity to endotoxin-induced lethality.Q38329525
Short-term and long-term leptin exposure differentially affect human natural killer cell immune functionsQ38331523
Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthmaQ38336229
Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infectionQ38481730
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.Q38811539
Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN.Q39579071
Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitisQ40067482
Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.Q40106388
Generation of leptin receptor bone marrow chimeras: recovery from irradiation, immune cellularity, cytokine expression, and metabolic parametersQ40251396
Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface.Q40811252
Gamma/delta cells.Q40898241
Molecular and cellular biology of dendritic epidermal T cellsQ41265175
Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptorQ41268795
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.Q41275648
Successful modulation of type 2 diabetes in db/db mice with intra-bone marrow--bone marrow transplantation plus concurrent thymic transplantationQ41362402
Modulation of epithelial cell growth by intraepithelial gamma delta T cellsQ41428419
Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.Q41511567
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesityQ41834087
A nomenclature to fit the organization of the human T-cell receptor gamma and delta genesQ41916513
Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitisQ41951968
T-cell receptor-gamma/delta bearing lymphocytes in normal and inflammatory human skinQ42478884
Effect of hyperglycemia on the basal cytosolic free calcium level, calcium signal and tyrosine-phosphorylation in human T-cellsQ42521288
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitmentQ42593305
Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndromeQ43192053
Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese miceQ43243138
Obesity predisposes to Th17 biasQ43296795
Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68.Q43827252
Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumoniaQ43950679
Gamma/delta T cells and the diagnosis of coeliac diseaseQ44244291
Comparison of sirolimus vs. mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantationQ44549982
Expression and synthesis of fibroblast growth factor-9 in human gammadelta T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-beta1/IL-15.Q44712643
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virusQ45391773
Virus-induced activation of self-specific TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes does not abolish their self-tolerance in the intestine.Q45662448
Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1.Q46384333
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese miceQ46663069
Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetesQ46697243
Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db miceQ46701598
Effect of high fat diet on NKT cell function and NKT cell-mediated regulation of Th1 responsesQ46787446
A keratinocyte-responsive gamma delta TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermisQ47991874
Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation.Q51024856
A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside, Scotland.Q51140774
Plasma free fatty acid turnover rate in obesityQ51686505
Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators.Q51891435
Distribution and leukocyte contacts of gammadelta T cells in the lung.Q52993270
gamma delta T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium.Q53033463
Cutting edge: Gammadelta intraepithelial lymphocytes of the small intestine are not biased toward thymic antigens.Q53057116
Impact of body mass index and obesity on clinical response to systemic treatment for psoriasis. Evidence from the Psocare project.Q53130017
Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel diseaseQ53812838
Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.Q54067088
Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy.Q54176069
Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profileQ56776935
Alterations in T-Cell Subset Frequency in Peripheral Blood in ObesityQ57434624
Blunted T-lymphocyte response in chronic obstructive pulmonary diseaseQ58840523
Dietary factors and the risk of psoriasis. Results of an Italian case–control studyQ59446444
CD4+Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammationQ60452024
Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel diseaseQ61892557
Cellular mechanisms of insulin resistanceQ29619549
Immunological and inflammatory functions of the interleukin-1 familyQ29619669
Adipokines in inflammation and metabolic diseaseQ29620456
Diet-induced obesity impairs the T cell memory response to influenza virus infection.Q30385873
Obesity is associated with impaired immune response to influenza vaccination in humansQ30408577
The influence of body mass index on skin susceptibility to sodium lauryl sulphateQ31053418
The role of gammadelta T cells in the regulation of neutrophil-mediated tissue damage after thermal injuryQ33203757
T cells of the gammadelta T-cell receptor lineage play an important role in the postburn wound healing processQ33237725
Resistance of Janus kinase-2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesityQ33324814
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infectionsQ33410795
Fatty acids, lipotoxicity and insulin secretionQ33537945
Nutrient sensing and inflammation in metabolic diseasesQ33623354
Obesity enhances eosinophilic inflammation in a murine model of allergic asthma.Q33685925
T-Lymphocyte Responses to Intestinally Absorbed Antigens Can Contribute to Adipose Tissue Inflammation and Glucose Intolerance during High Fat FeedingQ33750001
Obesity among HIV-infected persons: impact of weight on CD4 cell countQ33883870
Leptin in the regulation of immunity, inflammation, and hematopoiesisQ33922050
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.Q34063643
MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsivenessQ34066100
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceQ34118282
γδ T cells protect against lung fibrosis via IL-22Q34161552
Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cellsQ34196269
Epidermal and dermal gamma-delta T cells.Q34322228
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.Q34373760
Protection of the intestinal mucosa by intraepithelial gamma delta T cellsQ34393641
IL-17 regulates adipogenesis, glucose homeostasis, and obesityQ34401701
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activationQ34416242
Adipose tissues as an ancestral immune organ: site-specific change in obesity.Q34426141
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.Q34434443
Evaluation of the immunoregulatory activity of intraepithelial lymphocytes in a mouse model of chronic intestinal inflammation.Q34541405
Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative studyQ34557259
Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study.Q34558876
Influence of body fat distribution on free fatty acid metabolism in obesityQ34570120
Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy MenQ34571826
Smoking, Physical Activity, Nutrition and Lifestyle: Environmental Factors and Their Impact on IBDQ34624222
Impact of body mass index on retention rates of anti-TNF-alfa drugs in daily practice for psoriasisQ34631127
Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitroQ34802235
Normalization of obesity-associated insulin resistance through immunotherapyQ34994222
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surfaceQ35008436
Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel diseaseQ35048180
Macrophages and post-burn immune dysfunctionQ35051206
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesityQ35095489
The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trialQ35111527
Activated T lymphocytes in Type 2 diabetes: implications from in vitro studiesQ35179248
Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasisQ35276090
Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expressionQ35361010
Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndromeQ35384250
Effects of etanercept in patients with the metabolic syndromeQ35384380
Dysfunctional γδ T cells contribute to impaired keratinocyte homeostasis in mouse models of obesityQ35541650
Salsalate improves glycemia and inflammatory parameters in obese young adultsQ35580779
The role of leptin in innate and adaptive immune responsesQ35605670
TOR in the immune systemQ35621941
Analysis of gamma delta T cell functions in the mouseQ35765666
Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cellsQ35781960
Reduced leptin levels in starvation increase susceptibility to endotoxic shockQ35810100
Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factorQ35834619
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistanceQ35922894
Adipose tissue, inflammation, and cardiovascular diseaseQ36125401
Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.Q36227215
What does tumour necrosis factor excess do to the immune system long term?Q36292657
Gamma delta T cells provide an early source of interferon gamma in tumor immunityQ36371404
The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancerQ36371644
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signalingQ36377176
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cellsQ36384673
Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammationQ36403514
Changes in human mucosal gamma delta T cell repertoire and function associated with the disease process in inflammatory bowel diseaseQ36437700
The molecular biology of chronic wounds and delayed healing in diabetesQ36499284
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsQ36509846
P433issue3
P921main subjectobesityQ12174
P304page(s)182-199
P577publication date2012-06-01
P1433published inImmunologic ResearchQ15754981
P1476titleImmunomodulation at epithelial sites by obesity and metabolic disease
P478volume52

Reverse relations

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