An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism

scientific article published on February 14, 2011

An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.190165
P953full work available online athttp://intl.jbc.org/cgi/content/abstract/286/16/14508
http://www.jbc.org/article/S0021925820515421/pdf
https://api.elsevier.com/content/article/PII:S0021925820515421?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925820515421?httpAccept=text/xml
https://doi.org/10.1074/jbc.m110.190165
https://europepmc.org/articles/PMC3077649
https://europepmc.org/articles/PMC3077649?pdf=render
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.190165
P932PMC publication ID3077649
P698PubMed publication ID21321112

P50authorChaojun LiQ89415368
X YuQ57022397
P2093author name stringXiang Gao
Ning Shen
Bin Xue
Fei-Yan Pan
P2860cites workProtein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1Q24328752
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationQ24535576
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Comparison of the DNA Binding Characteristics of the Related Zinc Finger Proteins WT1 and EGR1Q74252154
Pathways of Egr-1-mediated gene transcription in vascular biologyQ24671655
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction proteinQ28116980
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)Q28139056
Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and humanQ28140183
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer modelQ28202775
Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathwaysQ28565051
Insulin-regulated expression of Egr-1 and Krox20: dependence on ERK1/2 and interaction with p38 and PI3-kinase pathwaysQ28569417
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphoryQ28645870
Protein prenylation: molecular mechanisms and functional consequencesQ29618038
A central role for JNK in obesity and insulin resistanceQ29619778
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
Islet beta cell failure in type 2 diabetesQ34698810
From mice to men: insights into the insulin resistance syndromesQ36387884
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistanceQ36491374
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleQ37175187
Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP miceQ38345332
Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-αQ38349579
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptorQ38359478
Early growth response-1 induction by fibroblast growth factor-1 via increase of mitogen-activated protein kinase and inhibition of protein kinase B in hippocampal neurons.Q39677407
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.Q39881878
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.Q39898733
Early growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcriptionQ40491773
Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factorsQ41099730
Human lamin B contains a farnesylated cysteine residueQ41847865
Identification of geranylgeranyl-modified proteins in HeLa cellsQ42060794
Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertensionQ42459167
Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endotheliumQ42459595
Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammationQ42468886
Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanismQ42521940
Co-culture with fat cells induces cellular insulin resistance in primary hepatocytesQ42801641
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytesQ42805810
Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.Q42820548
Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.Q42824711
A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation.Q43697195
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signallingQ43848062
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylationQ44268162
Acquirement of brown fat cell features by human white adipocytesQ44478768
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.Q44605205
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptideQ45078360
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin actionQ46212774
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
type 2 diabetesQ3025883
preproinsulinQ7240673
P304page(s)14508-14515
P577publication date2011-02-14
P1433published inJournal of Biological ChemistryQ867727
P1476titleAn early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism
An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism
P478volume286

Reverse relations

cites work (P2860)
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Q58604185Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2
Q92348371Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms
Q35953653Comorbidities of Psoriasis - Exploring the Links by Network Approach
Q36693333Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2
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