Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

scientific article published on 11 April 2015

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1008843965
P356DOI10.1007/S11427-015-4836-1
P698PubMed publication ID25862656
P5875ResearchGate publication ID274781540

P50authorXiuxing WangQ47696665
P2093author name stringShan Jiang
Ning Shen
Bin Xue
Na Xu
ChaoJun Li
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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cQ33785270
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failureQ33853316
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Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseasesQ34225670
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Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.Q34286104
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitorsQ34427029
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Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signalingQ34755883
An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinismQ34800387
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Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in miceQ35214910
GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylationQ35679537
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancerQ35762090
One tissue, two fates: molecular genetic events that underlie testis versus ovary developmentQ35813860
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Protein isoprenylation in biology and disease: general overview and perspectives from studies with genetically engineered animals.Q36814039
Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infectionQ37055519
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Network analysis of the MVA and MEP pathways for isoprenoid synthesisQ38085641
The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesisQ38315104
Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiationQ39454540
Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblastsQ39479291
The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiationQ39556401
MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine productionQ40134262
The nuclear receptor LXR is a glucose sensorQ40190911
Mumps orchitis in the non-immune postpubertal male: a resurgent threat to male fertility?Q40366936
Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblastsQ42738488
Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptorsQ43110157
Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive ratsQ43267632
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.Q46009276
The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.Q47072672
Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease.Q50721676
Sertoli cells initiate testicular innate immune responses through TLR activation.Q50774356
Liver fat in the metabolic syndrome.Q51468735
Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.Q54469603
P433issue4
P304page(s)328-335
P577publication date2015-04-11
P1433published inScience in China. Series C: Life SciencesQ2619480
P1476titleProtein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation
P478volume58

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cites work (P2860)
Q45766192Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition
Q48122685Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
Q92312055Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Q61450677Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma
Q46300593Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit
Q63547192Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance
Q47645395Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Q50916054Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants.

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