On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.

scientific article

On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M310081200
P698PubMed publication ID14625273

P50authorStephen G. YoungQ1350235
Bryant J GavinoQ125315809
Hsiao D LieuQ125316016
P2093author name stringPatrick J Casey
Martin O Bergo
James C Otto
Patricia Ambroziak
Quinn M Walker
P2860cites workA Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.Q41471661
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membraneQ41718569
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cellsQ43882525
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.Q46009276
Hematologic effects of inactivating the Ras processing enzyme Rce1.Q46518410
Signal transduction. How receptors turn Ras on.Q55066288
Conditional gene targetingQ57198351
Cloning and characterization of a mammalian prenyl protein-specific proteaseQ22009066
Isoprenylcysteine carboxyl methyltransferase deficiency in miceQ24290644
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulumQ24321665
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnantsQ24564846
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylationQ24671540
RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteinsQ27936473
Modulation of Ras and a-factor function by carboxyl-terminal proteolysisQ27936659
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system diseaseQ28139053
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
Selective requirement of myosin light chain 2v in embryonic heart functionQ28258434
Protein prenyltransferasesQ28277579
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cellsQ28506731
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cellsQ28586789
Biochemical studies of Zmpste24-deficient miceQ28588204
Inducible gene targeting in miceQ29614544
Protein prenylation: molecular mechanisms and functional consequencesQ29618038
Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.Q30479148
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout miceQ33852162
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosisQ33995709
Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospectsQ34136641
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformationQ34290291
Protein lipidation in cell signalingQ34308460
Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.Q37369799
Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase geneQ37624048
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathwayQ39451813
Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude miceQ40977224
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
P304page(s)4729-4736
P577publication date2003-11-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleOn the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy
P478volume279

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cites work (P2860)
Q358788178-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.
Q40765561ASG2 is a farnesylated DWD protein that acts as ABA negative regulator in Arabidopsis.
Q46620985Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy
Q37758841Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase
Q40312690Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.
Q37138752Genetic analyses of the role of RCE1 in RAS membrane association and transformation.
Q42827129H-Ras does not need COP I- or COP II-dependent vesicular transport to reach the plasma membrane.
Q27680718Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1
Q33653120Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.
Q24611091Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues
Q34006187Porcine Liver Carboxylesterase Requires Polyisoprenylation for High Affinity Binding to Cysteinyl Substrates
Q81703538Post-prenylation-processing enzymes as new targets in oncogenesis
Q100762044Post-translational modification of KRAS: potential targets for cancer therapy
Q24305028Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis
Q36021728Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic
Q38415670Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation
Q38704283Protein prenylation: unique fats make their mark on biology
Q33228701Proteomic analysis of bovine brain G protein gamma subunit processing heterogeneity
Q35008463RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments
Q36952890Ras nanoclusters: molecular structure and assembly
Q50102683Rce1: mechanism and inhibition
Q33890598Recombinant expression and functional analysis of proteases from Streptococcus pneumoniae, Bacillus anthracis, and Yersinia pestis
Q41898753Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins
Q34166819Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice
Q28255336Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
Q47271754Small change, big effect: taking RAS by the tail through suppression of post-prenylation carboxylmethylation
Q38423044Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
Q33943379Therapeutic intervention based on protein prenylation and associated modifications
Q39262217Therapeutic strategies for targeting ras proteins
Q24328791USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

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