RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments

scientific article

RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.8862C
P356DOI10.1073/PNAS.1103627108
P932PMC publication ID3102416
P698PubMed publication ID21555557
P5875ResearchGate publication ID51110757

P50authorVisvanathan RamamurthyQ55137350
P2093author name stringMartin O Bergo
Jeffrey R Christiansen
Saravanan Kolandaivelu
P2860cites workFarnesylated γ-subunit of photoreceptor G protein indispensable for GTP-bindingQ59072746
A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunitQ69352173
Methylation of proteins in photoreceptor rod outer segmentsQ70158717
Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesteraseQ70219052
Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transductionQ72238110
Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunitsQ73153221
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic miceQ73473626
Post-prenylation-processing enzymes as new targets in oncogenesisQ81703538
Isoprenylcysteine carboxyl methyltransferase deficiency in miceQ24290644
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteinsQ24297621
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosisQ24554290
In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunitsQ28208628
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type IQ28297279
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cellsQ28506731
Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viabilityQ28508147
Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesteraseQ28509144
Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segmentsQ28609986
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationQ29615355
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Protein prenylation: molecular mechanisms and functional consequencesQ29618038
The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cellsQ33697709
Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPasesQ33734499
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and GolgiQ34061239
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.Q34277651
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformationQ34290291
The membrane binding domain of rod cGMP phosphodiesterase is posttranslationally modified by methyl esterification at a C-terminal cysteineQ34322567
Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent.Q34400887
Beyond counting photons: trials and trends in vertebrate visual transductionQ34465227
Morphological, physiological, and biochemical changes in rhodopsin knockout miceQ34853562
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative diseaseQ35615842
Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.Q35829073
Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit geneQ36274060
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.Q36382566
Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.Q36423684
Assembly and trafficking of heterotrimeric G proteinsQ36845087
The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptorsQ36955713
Signal transducing membrane complexes of photoreceptor outer segmentsQ37041964
AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assemblyQ37431368
ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disordersQ37488230
Prenyl proteins in eukaryotic cells: a new type of membrane anchorQ37923158
Expression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesteraseQ38311330
From mice to men: the cyclic GMP phosphodiesterase gene in vision and disease. The Proctor Lecture.Q40584439
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinasesQ41603357
The cGMP-gated channel of the rod photoreceptor cell characterization and orientation of the amino terminusQ41656840
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectphotoreceptor proteinQ7187894
P304page(s)8862-8866
P577publication date2011-05-09
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments
P478volume108

Reverse relations

cites work (P2860)
Q37508574AIPL1, A protein linked to blindness, is essential for the stability of enzymes mediating cGMP metabolism in cone photoreceptor cells
Q28000117ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting
Q36863992Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function
Q35546967Detergents stabilize the conformation of phosphodiesterase 6.
Q49448661Farnesylation of the Transducin G Protein Gamma Subunit Is a Prerequisite for Its Ciliary Targeting in Rod Photoreceptors
Q35971565Greasing the protein biosynthesis machinery of photoreceptor neurons: Role for postprenylation processing of proteins
Q28584989Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding
Q91943084Loss of MPC1 reprograms retinal metabolism to impair visual function
Q27680718Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1
Q28610521Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture
Q48232458Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches
Q38704283Protein prenylation: unique fats make their mark on biology
Q37313093RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
Q50102683Rce1: mechanism and inhibition
Q38058956Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions
Q90664456Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1
Q38423044Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
Q36445794The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking

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