Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

scientific article

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E02-07-0390
P932PMC publication ID151564
P698PubMed publication ID12631708

P50authorElizabeth O. HarringtonQ37387221
P2093author name stringQing Lu
Sharon Rounds
Julie Newton
Kristina Kramer
Kerri L Sheahan
Robert Bellas
P2860cites workInhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteineQ73735641
PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RASQ73816410
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremiaQ73947970
Homocysteine and atherothrombosisQ74424094
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cellsQ77829463
The carboxyl methyltransferase modifying G proteins is a metalloenzymeQ22003759
Isoprenylcysteine carboxyl methyltransferase deficiency in miceQ24290644
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulumQ24321665
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferasesQ24647831
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membraneQ27937876
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrateQ28297420
Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transductionQ28333826
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cellsQ28586789
Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosisQ31834254
Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagyQ31920868
Role of mesenchymal cell death in lung remodeling after injury.Q34113778
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesisQ35904374
Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosisQ40806056
Transcriptional regulation of rat Na(+)/H(+) exchanger isoform-2 (NHE-2) gene by Sp1 transcription factorQ40814983
Hepatocytes sensitized to tumor necrosis factor-alpha cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathwaysQ40908958
Isoprenylation/methylation of proteins enhances membrane association by a hydrophobic mechanismQ41015099
Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cellsQ41245981
Selective Inhibition of Ras-dependent Cell Growth by Farnesylthiosalisylic AcidQ41294243
Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factorQ41553089
Resistance to cytolysis by tumor necrosis factor alpha in malignant gynecological cell lines is associated with the expression of protein(s) that prevent the activation of phospholipase A2 by tumor necrosis factor alphaQ41639597
Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cellsQ41925887
Guanosine induces necrosis of cultured aortic endothelial cells.Q42074371
Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cellsQ42547945
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathwayQ42618265
Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunctionQ43606149
FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinaseQ43954405
Rho GTPasesQ47724821
Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.Q52535032
Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis.Q52566730
Determination of GTP loading on RhoQ57446974
Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophilsQ57731069
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophilsQ57731072
Analogs of farnesylcysteine induce apoptosis in HL-60 cellsQ63345653
Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboonsQ71097689
Prenylcysteine-directed carboxyl methyltransferase activity in human neutrophil membranesQ71521907
Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cellsQ72005909
Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesisQ72716141
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
endotheliumQ111140
apoptotic processQ14599311
P304page(s)848-857
P577publication date2003-03-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleIsoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis
P478volume14

Reverse relations

cites work (P2860)
Q386832079 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing
Q33934228A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
Q33784115Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis
Q42465564Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium
Q55016760Betaine in Inflammation: Mechanistic Aspects and Applications.
Q37758841Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase
Q33860004Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.
Q92348327Defining a role for lung function associated gene GSTCD in cell homeostasis
Q30459602Focal adhesion kinase and endothelial cell apoptosis
Q44920253Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos
Q24683861Inhibition of ICMT induces endothelial cell apoptosis through GRP94
Q39681605Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth
Q34187979Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease
Q39384869Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents
Q25257578Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies
Q36108766Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase
Q42146853Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin
Q81703538Post-prenylation-processing enzymes as new targets in oncogenesis
Q36856455Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Q47243831Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury
Q38605514Pulmonary endothelial cell signaling and function
Q35008463RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments
Q37271795RAS: target for cancer therapy
Q40181415Release of soluble E-selectin from activated endothelial cells upon apoptosis
Q79348182Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells
Q36939985Role of transmethylation reactions in alcoholic liver disease
Q36808007Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.

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