Loss of MPC1 reprograms retinal metabolism to impair visual function

scientific article published on 11 February 2019

Loss of MPC1 reprograms retinal metabolism to impair visual function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1812941116
P932PMC publication ID6397593
P698PubMed publication ID30808746

P50authorVisvanathan RamamurthyQ55137350
Jianhai DuQ91943078
P2093author name stringTongju Guan
Quan Shi
Andrew F X Goldberg
Nancy J Philp
James B Hurley
Saravanan Kolandaivelu
Jonathan D Linton
Aditi Swarup
Joseph Murphy
Yekai Wang
Tanya L Dilan
Michelle Yam
Allison Hauer
Daniel Lohner
Siyan Zhu
Allison Grenell
Elizabeth Gregor
P2860cites workCytosolic reducing power preserves glutamate in retinaQ37319656
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retinaQ37388865
The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the RetinaQ37436031
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degenerationQ37452246
Reductive carboxylation is a major metabolic pathway in the retinal pigment epitheliumQ37534139
Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.Q38584562
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolismQ38622483
Modifications in Retinal Mitochondrial Respiration Precede Type 2 Diabetes and Protracted Microvascular Retinopathy.Q38649182
M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.Q38802353
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine CyclingQ38837452
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.Q38933788
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.Q41671792
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal deathQ41946111
Retinoschisin is linked to retinal Na/K-ATPase signaling and localizationQ42338638
Monocarboxylate transport inhibition alters retinal function and cellular amino acid levels.Q45049898
A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α.Q50438839
Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.Q51730277
Vertebrate photoreceptor cell development and disease.Q53730809
Energy metabolism of rabbit retina as related to function: high cost of Na+ transportQ55036895
Mitochondria: Potential Targets for Protection in Age-Related Macular DegenerationQ58118563
Distribution of membrane proteins in mechanically dissociated retinal rodsQ69837081
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humansQ27931310
Identification and functional expression of the mitochondrial pyruvate carrierQ27936768
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycleQ28118878
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitorsQ28339341
The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinasesQ28385023
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretionQ28512730
Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to lightQ28565653
Conditional Müllercell ablation causes independent neuronal and vascular pathologies in a novel transgenic modelQ33581991
Glycolytic reliance promotes anabolism in photoreceptorsQ33879266
The retinal pigment epithelium utilizes fatty acids for ketogenesisQ33947025
Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retinaQ34442074
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growthQ34718277
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segmentsQ35008463
Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative StressQ35691965
Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retinaQ35828846
Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic DietQ36017259
Glutamine synthetase protects against neuronal degeneration in injured retinal tissueQ36247136
Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.Q36583178
P433issue9
P304page(s)3530-3535
P577publication date2019-02-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLoss of MPC1 reprograms retinal metabolism to impair visual function
P478volume116