H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

scientific article

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.20.7.2475-2487.2000
P8608Fatcat IDrelease_yw5ae3ml4bhnhp2eklsxtz27eq
P932PMC publication ID85443
P698PubMed publication ID10713171

P50authorRobert G. PartonQ30347571
P2093author name stringA Apolloni
I A Prior
M Lindsay
J F Hancock
P2860cites workCloning and characterization of a mammalian prenyl protein-specific proteaseQ22009066
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulumQ24321665
Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranesQ24336596
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformationQ24562853
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding proteinQ24598539
Rab11 regulates recycling through the pericentriolar recycling endosomeQ24681897
Functional rafts in cell membranesQ27860768
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteinsQ27935631
Modulation of Ras and a-factor function by carboxyl-terminal proteolysisQ27936659
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformationQ28114914
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
Increasing complexity of Ras signaling.Q53429989
The p21 ras C-terminus is required for transformation and membrane associationQ53551139
Translocation of Ki-ras p21 between membrane and cytoplasm by smg GDSQ70575593
A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiaeQ72136028
Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc fingerQ73555600
Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulatorQ73994488
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinaseQ77195536
Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signalingQ77631079
All ras proteins are polyisoprenylated but only some are palmitoylatedQ28270312
The complexity of Raf-1 regulationQ28305850
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cellsQ28506731
Caveolin-3 associates with developing T-tubules during muscle differentiationQ28511690
ER-to-Golgi transport visualized in living cellsQ29547526
ras oncogenes in human cancer: a reviewQ29547769
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membraneQ29618478
Activation of Raf as a result of recruitment to the plasma membraneQ29618481
Regulation of RasGRP via a phorbol ester-responsive C1 domain.Q31973953
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysisQ33562770
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.Q33785693
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptidesQ34219356
Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharidesQ34300298
p21ras is modified by a farnesyl isoprenoidQ34315409
Ras effectors and their role in mitogenesis and oncogenesisQ34439160
The murine N-ras gene is not essential for growth and developmentQ34650223
Control of the ERK MAP kinase cascade by Ras and Raf.Q34662994
K-ras is an essential gene in the mouse with partial functional overlap with N-rasQ35192456
Protein isoprenylation and methylation at carboxyl-terminal cysteine residuesQ35671041
Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitroQ36220495
Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathwayQ36342168
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiaeQ36727122
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteinsQ38316770
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathwaysQ38354870
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.Q39481540
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domainsQ40918552
Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.Q40977491
Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.Q40982625
Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivoQ41054513
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivoQ41069980
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.Q41083682
Prenylation and palmitoylation analysisQ41388759
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.Q41514986
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membraneQ41718569
Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular traffickingQ42833741
Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesiclesQ45345737
Microsomal membranes contain a high affinity binding site for prenylated peptidesQ48250254
Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.Q52379805
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2475-2487
P577publication date2000-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleH-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
P478volume20

Reverse relations

cites work (P2860)
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Q33967144Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
Q44012141The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity
Q33878815The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation
Q41260462The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties
Q38723395The G protein-coupled receptor GPR31 promotes membrane association of KRAS.
Q39426327The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins
Q42828406The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
Q49798156The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis
Q41900845The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins
Q90089701The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease
Q37622606The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.
Q24295264The complex of Arl2-GTP and PDE delta: from structure to function
Q34189442The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras
Q39983039The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected
Q28660742The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells
Q24540862The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes
Q39007227The grab-and-drop protocol: a novel strategy for membrane protein isolation and reconstitution from single cells.
Q41841993The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway
Q43786808The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase
Q39896125The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse
Q47128365The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part
Q40634841The paranodal complex of F3/contactin and caspr/paranodin traffics to the cell surface via a non-conventional pathway.
Q35566863The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
Q38077211The role of palmitoylation in regulating Ras localization and function.
Q30375564The role of the cytoskeleton in the formation of gap junctions by Connexin 30.
Q47734724The role of toxins in Clostridium difficile infection.
Q34774553The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons
Q34575170Trafficking and signaling by fatty-acylated and prenylated proteins
Q35044902Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.
Q59791944UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras
Q24328791USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity
Q37180578VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking
Q38719156Where no Ras has gone before: VPS35 steers N-Ras through the cytosol.
Q34989253While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

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