Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

scientific article published on 9 September 2011

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ANIE.201102965
P698PubMed publication ID21905185

P50authorHerbert WaldmannQ1609256
Robin S. BonQ39476848
Frank J DekkerQ39476878
P2093author name stringStefan Wetzel
Steffen Renner
Christian Hedberg
Claas Gerding-Reimers
Nachiket Vartak
Philippe I H Bastiaens
Marion Rusch
P2860cites workSmall-molecule inhibition of APT1 affects Ras localization and signalingQ24307840
Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 AQ27628348
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)Q28273568
An acylation cycle regulates localization and activity of palmitoylated Ras isoformsQ28306968
Compound library development guided by protein structure similarity clustering and natural product structureQ30344285
Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.Q30350832
Bioactivity-guided navigation of chemical spaceQ30389362
Biology-inspired synthesis of compound librariesQ33314572
Therapeutic intervention based on protein prenylation and associated modificationsQ33943379
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteinsQ34111893
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization productsQ34756212
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesisQ34771016
Ras proteins: different signals from different locationsQ35120159
Lipidated ras and rab peptides and proteins--synthesis, structure, and functionQ36619526
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesisQ36678825
Protein acyl thioesterases (Review).Q37359990
Ras-MAPK pathway as a therapeutic target in cancer--emphasis on bladder cancer.Q37516197
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathwayQ39451813
Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.Q39852136
Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screeningQ40597107
Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitroQ40781982
Cloning, expression, and catalytic mechanism of murine lysophospholipase I.Q41110642
Purification and properties of lysophospholipase isoenzymes from pig gastric mucosaQ42160571
Regiospecificity and catalytic triad of lysophospholipase I.Q43501837
Boron-mediated aldol reaction of carboxylic esters: complementary anti- and syn-selective asymmetric aldol reactionsQ44069924
Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomachQ45157348
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.Q46460108
Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und FunktionQ57531482
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectprotein designQ410814
P304page(s)9832-9837
P577publication date2011-09-09
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleDevelopment of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design
P478volume50

Reverse relations

cites work (P2860)
Q52350987Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.
Q90434318Activity-Based Sensing of S-Depalmitoylases: Chemical Technologies and Biological Discovery
Q34789296Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation
Q47445934Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery.
Q34317561Boron-based inhibitors of acyl protein thioesterases 1 and 2.
Q28534102Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins
Q42028708Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii
Q34266996Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery
Q34785627Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases
Q38534932Current status of the development of Ras inhibitors
Q45228186Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain
Q28533449Exploring anti-bacterial compounds against intracellular Legionella
Q36957153Fat chance! Getting a grip on a slippery modification
Q30844739Individual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles
Q38802497Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).
Q42578090Multiexcitation Fluorogenic Labeling of Surface, Intracellular, and Total Protein Pools in Living Cells
Q100156054Palmostatin B binds RAS depalmitoylases
Q38568187Pharmacological Inhibition of Protein Lipidation
Q47223139Posttranslational Modifications of RAS Proteins.
Q36673837Profiling and inhibiting reversible palmitoylation
Q47239374Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
Q47295054Protein depalmitoylases.
Q35188280Small-molecule modulation of Ras signaling
Q41107898Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation
Q39392568Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin
Q34589404Target identification for small bioactive molecules: finding the needle in the haystack
Q64263350Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
Q38423044Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
Q36352506Targeting oncogenic Ras signaling in hematologic malignancies
Q38223437Targeting protein palmitoylation: selective inhibitors and implications in disease
Q44175173The mechanism of caseinolytic protease (ClpP) inhibition
Q34003766Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging.

Search more.