Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction (scientific article published on 06 August 2009)

The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype

Q24299527

A novel switch region regulates H-ras membrane orientation and signal output

Q24313439

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

Q27824827

Targeting RAS signalling pathways in cancer therapy

Q28201363

All ras proteins are polyisoprenylated but only some are palmitoylated

Q28270312

Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

Q28568636

Identification of nucleolin as new ErbB receptors- interacting protein

Q28578177

Ras plasma membrane signalling platforms

Q28769530

ras oncogenes in human cancer: a review

Q29547769

Major nucleolar proteins shuttle between nucleus and cytoplasm

Q29620425

Single-molecule imaging analysis of Ras activation in living cells

Q30583761

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

Q30830747

Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices

Q33220894

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

Q34098381

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Q36322914

The dynamics of postmitotic reassembly of the nucleolus

Q36328472

Electrostatic interactions positively regulate K-Ras nanocluster formation and function

Q36748140

Activation of the MAPK module from different spatial locations generates distinct system outputs

Q36954216

K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.

Q36983120

Ras nanoclusters: combining digital and analog signaling

Q37062789

Using plasma membrane nanoclusters to build better signaling circuits

Q37213906

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

Q38321981

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

Q39451813

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

Q39804200

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

Q40315264

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

Q40321232

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

Q40815505

Displaced amacrine cells in the retina of a rabbit: analysis of a bivariate spatial point pattern

Q41478021

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

Q41718569

Nucleolin functions in the first step of ribosomal RNA processing.

Q42639990

Subcellular localization determines MAP kinase signal output.

Q51470882

Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells.

Q51839948

Nucleophosmin and human cancer.

Q53339902

Formation of nucleophosmin/B23 oligomers requires both the amino- and the carboxyl-terminal domains of the protein.

Q54691682

A comparison between parametric and non-parametric approaches to the analysis of replicated spatial point patterns

Q58852173

In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells

Q73035218

Mechanism of mitosis-specific activation of MEK1

Q73062625

Mapping the functional domains of nucleolar protein B23

Q73829236

K-Ras4B proteins are expressed in the nucleolus: Interaction with nucleolin

Q80061922

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

28410-28419

P577

publication date

2009-08-06

P1433

published in

Journal of Biological Chemistry

Q867727

P1476

title

Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction

P478

volume

284

Reverse relations

cites work (P2860)

Q36082699	ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.
Q34620114	Alterations in the nuclear proteome of HIV-1 infected T-cells
Q54988217	Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.
Q24338790	Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA
Q41807072	CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators.
Q39061507	Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori
Q34059317	Expression of PTRF in PC-3 Cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways
Q38777463	Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering
Q90220998	Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLCε/PKCε Signaling Pathway
Q28082431	Insights into the regulation of neuronal viability by nucleophosmin/B23
Q35911995	Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.
Q58098402	Modeling and subtleties of K-Ras and Calmodulin interaction
Q33567915	NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells
Q36534039	Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
Q33931038	Nucleophosmin and nucleolin regulate K-Ras signaling
Q30431834	Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity
Q53143098	Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway.
Q43074397	Perillyl alcohol: Dynamic interactions with the lipid bilayer and implications for long-term inhalational chemotherapy for gliomas
Q52668813	Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex.
Q39578288	RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway
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Q36043314	Ras trafficking, localization and compartmentalized signalling
Q35818835	Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
Q33784401	Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization
Q38423044	Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
Q33980633	Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type
Q27661333	The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46
Q36669604	The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding
Q89087147	Translational Dynamics of Lipidated Ras Proteins in the Presence of Crowding Agents and Compatible Osmolytes
Q39448707	Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells

P356	DOI	10.1074/JBC.M109.001537
P8608	Fatcat ID	release_7v5flj3vlbdmhglj3krh4775yq
P932	PMC publication ID	2788890
P698	PubMed publication ID	19661056