Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

scientific article published on 16 June 2015

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.7996N
P356DOI10.1073/PNAS.1509123112
P932PMC publication ID4491781
P698PubMed publication ID26080442
P5875ResearchGate publication ID280032847

P50authorSteven ChuQ172466
Xiaolin NanQ55079941
Joe W. GrayQ85648340
Eric CollissonQ90503917
P2093author name stringFrank McCormick
Jacqueline Galeas
Li-Jung Lin
Cameron Pitt
Sophia Lewis
Tanja M Tamgüney
P2860cites workKinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
Ultra-high resolution imaging by fluorescence photoactivation localization microscopyQ24673523
Photoactivated localization microscopy with bimolecular fluorescence complementation (BiFC-PALM) for nanoscale imaging of protein-protein interactions in cellsQ27322523
Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent statesQ27658315
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactionsQ27680654
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificityQ27765263
Imaging intracellular fluorescent proteins at nanometer resolutionQ27860767
A dimerization-dependent mechanism drives RAF catalytic activationQ27865239
Active Ras induces heterodimerization of cRaf and BRafQ28185999
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signalingQ28190246
RAS oncogenes: weaving a tumorigenic webQ28250360
A versatile viral system for expression and depletion of proteins in mammalian cellsQ28475909
Ras oncogenes: split personalitiesQ29615405
Hyperactive Ras in developmental disorders and cancerQ29616397
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)Q29620033
Ras history: The saga continuesQ30404024
H-Ras forms dimers on membrane surfaces via a protein-protein interface.Q30573159
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage responseQ33778215
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeletonQ34098381
Ras proteins: different signals from different locationsQ35120159
Direct visualization of Ras proteins in spatially distinct cell surface microdomainsQ36322914
Ras nanoclusters: molecular structure and assemblyQ36952890
K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.Q36983120
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsQ37048053
Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory.Q37218563
Lessons from computer simulations of Ras proteins in solution and in membraneQ37301995
Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signalingQ37319491
Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transductionQ37460012
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 moleculesQ37567878
Quantitative super-resolution microscopy: pitfalls and strategies for image analysisQ38209099
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.Q40315264
Wildtype Kras2 can inhibit lung carcinogenesis in miceQ40783010
Formation of the Ras dimer is essential for Raf-1 activationQ40902029
N-Ras forms dimers at POPC membranesQ42425935
RAS oncogenes: the first 30 years.Q55036584
P433issue26
P407language of work or nameEnglishQ1860
P304page(s)7996-8001
P577publication date2015-06-16
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRas-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
P478volume112

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