Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.

scientific article

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/21541248.2017.1333188
P8608Fatcat IDrelease_kbql34f3nfhoxbsszlmf53qkg4
P932PMC publication ID6748372
P698PubMed publication ID28692342

P50authorJohn P O'BryanQ84582721
Russell Spencer-SmithQ88483734
P2093author name stringAkiko Koide
Shohei Koide
Lie Li
Sheela Prasad
P2860cites workRas nanoclusters: Versatile lipid-based signaling platformsQ38252413
The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic DomainQ38310579
Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.Q39231834
The Ras G Domain Lacks the Intrinsic Propensity to Form DimersQ40583259
GTP-dependent segregation of H-ras from lipid rafts is required for biological activityQ40815505
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membraneQ41718569
N-Ras forms dimers at POPC membranesQ42425935
Functional specificity of ras isoforms: so similar but so differentQ42784309
Dimerization opens new avenues into Ras signaling researchQ43490714
Nonradioactive determination of Ras-GTP levels using activated ras interaction assayQ43635841
Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteinsQ44953937
NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activationQ45112645
US National Cancer Institute's new Ras project targets an old foe.Q46929162
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinaseQ77195536
A novel switch region regulates H-ras membrane orientation and signal outputQ24313439
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activityQ27678097
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated ActivationQ27678948
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactionsQ27680654
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeQ27681830
Targeting RAS signalling pathways in cancer therapyQ28201363
The Ras superfamily at a glanceQ29617344
A comprehensive survey of Ras mutations in cancerQ30416821
H-Ras forms dimers on membrane surfaces via a protein-protein interface.Q30573159
Ras membrane orientation and nanodomain localization generate isoform diversityQ33667116
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptidesQ34219356
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitorsQ34427029
Inhibition of Ras-Effector Interaction by Cyclic PeptidesQ34668051
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helicesQ35089991
Drugging the undruggable RAS: Mission possible?Q35163434
Three separable domains regulate GTP-dependent association of H-ras with the plasma membraneQ35663831
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding siteQ35669207
Direct Inhibitors of Ras-Effector Protein InteractionsQ35794271
Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathwayQ35818835
Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.Q36038664
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanismQ37113394
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.Q37398069
Inhibition of RAS function through targeting an allosteric regulatory site.Q37540897
Dragging ras back in the ringQ38197825
P4510describes a project that usesImageJQ1659584
P433issue5
P304page(s)378-387
P577publication date2017-12-31
P1433published inSmall GTPases (journal)Q15709529
P1476titleTargeting the α4-α5 interface of RAS results in multiple levels of inhibition
P478volume10

Reverse relations

cites work (P2860)
Q49721819Direct inhibition of RAS: Quest for the Holy Grail?
Q64084217Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges
Q47256433Oncogenic Ras Isoforms Signaling Specificity at the Membrane
Q90681757Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

Search more.