Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

scientific article (publication date: November 2001)

Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.21.21.7345-7354.2001
P932PMC publication ID99908
P698PubMed publication ID11585916

P50authorMarta BoschQ46862255
Priam VillalongaQ58762501
Richard MaraisQ30118915
Joan GilQ39031928
Neus AgellQ42808828
P2093author name stringC J Marshall
O Bachs
N Rocamora
A Chiloeches
C López-Alcalá
P2860cites workRegulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascadeQ24312887
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A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathwaysQ28142006
Proteins regulating Ras and its relativesQ28257295
New nuclear functions for calmodulinQ28271858
Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1Q28290353
Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1).Q42827172
The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site.Q42832751
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Q42991716
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibitionQ67852243
Calmodulin inhibits the epidermal growth factor receptor tyrosine kinaseQ67854307
Calmodulin and the cell cycle: involvement in regulation of cell-cycle progressionQ70307152
CalmodulinQ71480256
Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cellsQ71825158
The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascadeQ71973754
Overexpression of the myristoylated alanine-rich C-kinase substrate in Rat1 cells increases sensitivity to calmodulin antagonistsQ72796962
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinaseQ77195536
ras oncogenes in human cancer: a reviewQ29547769
ras genesQ29547799
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivoQ29615244
Mitogen-activated protein kinase pathwaysQ29618431
Phosphatidylinositol-3-OH kinase as a direct target of RasQ29620177
Ras caught in another affair: the exchange factors for Ral.Q33540078
Epidermal growth factor receptors: critical mediators of multiple receptor pathwaysQ33597368
Ras proteins: recent advances and new functions.Q33771484
How do small GTPase signal transduction pathways regulate cell cycle entry?Q33796334
Growth factor activation of MAP kinase requires cell adhesion.Q33887464
Signal transduction from multiple Ras effectorsQ34415796
The murine N-ras gene is not essential for growth and developmentQ34650223
Ras signalling and apoptosisQ34746668
Regulation of the calmodulin-stimulated protein phosphatase, calcineurinQ34747325
K-ras is an essential gene in the mouse with partial functional overlap with N-rasQ35192456
Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathwayQ35952074
Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteinsQ36288233
Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteinsQ36333750
Spectrin and related moleculesQ36427874
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.Q36572588
Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca(2+) and calmodulin.Q39584779
Phosphorylation of rat liver heterogeneous nuclear ribonucleoproteins A2 and C can be modulated by calmodulinQ40021377
High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.Q40023426
Calmodulin and calmodulin-binding proteins in the nucleusQ40569007
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.Q40845331
Role of basal calcium in the EGF activation of MAP kinasesQ40884737
Regulation of the cell cycle by calcium and calmodulinQ40906159
The multifunctional Ca2+/calmodulin-dependent protein kinasesQ40914645
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domainsQ40918552
Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localizationQ40934326
Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cellsQ40985633
Calmodulin modulates mitogen-activated protein kinase activation in response to membrane depolarization in PC12 cellsQ41039873
Ras effectorsQ41099716
Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cellsQ41109924
The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinaseQ41127933
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.Q41128325
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.Q41312875
Increasing complexity of Ras signal transduction: involvement of Rho family proteinsQ41617077
Calmodulin regulates DNA polymerase alpha activity during proliferative activation of NRK cellsQ41623918
Mechanism of activation and function of protein kinase B.Q41732739
Signal transduction through MAP kinase cascadesQ41750250
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)7345-54
P577publication date2001-11-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleCalmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling
P478volume21

Reverse relations

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