The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse

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The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.01421-08
P8608Fatcat IDrelease_b62stp4larhrfkc2y3bct7n7wq
P932PMC publication ID2648244
P698PubMed publication ID19139278

P50authorAndrey ShawQ42644311
Marina CellaQ55278809
Emanuele GiurisatoQ56804716
Marco ColonnaQ37377244
P2093author name stringRobert E Lewis
Joseph Lin
Angus Harding
Elisa Cerutti
P2860cites workIntercellular transfer of oncogenic H-Ras at the immunological synapseQ21144410
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The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAMQ24299577
Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lckQ24309126
KSR, a novel protein kinase required for RAS signal transductionQ24310039
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cellsQ24534351
Modeling T cell antigen discrimination based on feedback control of digital ERK responsesQ24814731
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)Q27637253
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and GolgiQ28140190
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulationQ28214524
The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesisQ42941711
Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killingQ43812084
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathwaysQ44308973
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.Q46331610
H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment.Q46633545
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylationQ47068888
Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.Q48537878
A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans.Q51012362
Subcellular localization determines MAP kinase signal output.Q51470882
Centrosome polarization delivers secretory granules to the immunological synapse.Q53587934
The immunological synapse of CTL contains a secretory domain and membrane bridges.Q53676857
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2Q57962185
Compartmentalization of Ras proteinsQ73773181
The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritisQ79287459
Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferationQ80571579
A role for phosphatidylinositol 3-kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulationQ81598348
The role of scaffold proteins in MEK/ERK signallingQ28269467
Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signalingQ28609078
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sitesQ28609103
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transductionQ28609144
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegansQ28609145
Coordinating ERK/MAPK signalling through scaffolds and inhibitorsQ29618995
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in MammalsQ29619598
Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.Q30442814
The mature activating natural killer cell immunologic synapse is formed in distinct stagesQ33715602
KSR: a MAPK scaffold of the Ras pathway?Q34222781
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivoQ34278674
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in DrosophilaQ34649122
KSR--a regulator and scaffold protein of the MAPK pathwayQ34681041
CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cellsQ34772159
KSR is a scaffold required for activation of the ERK/MAPK moduleQ35005553
Delivering the kiss of deathQ35116674
The role of the secretory immunological synapse in killing by CD8+ CTL.Q35682738
Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicityQ35748643
Scaffold proteins confer diverse regulatory properties to protein kinase cascades.Q35941359
Ras signaling from plasma membrane and endomembrane microdomainsQ36205175
Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicityQ36399700
Compartmentalized Ras/MAPK signalingQ36427391
The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathwayQ36515754
The MEK/ERK cascade: from signaling specificity to diverse functionsQ36656631
KSR stimulates Raf-1 activity in a kinase-independent mannerQ36709387
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.Q37274925
Formation and function of the lytic NK-cell immunological synapseQ37378585
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathwayQ39451813
Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapseQ40070389
Microtubule dynamics regulated by stathminQ40117819
Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen qualityQ40250804
The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cellsQ40560442
Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cellsQ41475516
Phosphorylation of serine 59 of p56lck in activated T cells.Q41514755
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)1554-1564
P577publication date2009-01-12
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse
P478volume29

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cites work (P2860)
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Q55462178IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.
Q37735337Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression
Q39872210KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs
Q41417837KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production
Q34595268Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells
Q37860083Molecular mechanisms of natural killer cell activation.
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Q28476397Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin
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Q38167946The newly found functions of MTOC in immunological response.
Q37468145The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse
Q37514034To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients
Q50583288Ultrastructural study of spermatogenesis in KSR2 deficient mice.

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