Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm

scientific article

Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/1933719111424449
P932PMC publication ID3343127
P698PubMed publication ID22228739
P5875ResearchGate publication ID221732594

P2093author name stringSung Tae Kim
Kelle H Moley
Kenan Omurtag
P2860cites workA human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domainQ22009089
Phosphorylation of the PTEN tail regulates protein stability and functionQ22254305
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaQ24669877
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesQ24672400
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancerQ28292541
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 geneQ28349476
GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocystQ28510376
Protein kinase B alpha/Akt1 regulates placental development and fetal growthQ28588076
Cellular survival: a play in three AktsQ29547806
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen qualityQ30857360
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.Q33783562
Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.Q33859164
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.Q34117304
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in miceQ34150841
Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracilQ34550955
Advances in protein kinase B signalling: AKTion on multiple frontsQ35766370
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.Q35965439
Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cellsQ37483007
The Control of Bovine Sperm Glycolysis During Epididymal TransitQ39978000
Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.Q41294455
Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levelsQ41428050
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulinQ42829524
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in miceQ43726502
Glucose transporter 8 expression and translocation are critical for murine blastocyst survivalQ44000508
Regulation of hepatic GLUT8 expression in normal and diabetic models.Q44405064
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.Q44605205
Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cellsQ44645813
Endocrine profile and testicular histomorphometry in adult rat offspring of diabetic mothers.Q45964335
Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation.Q45974630
Is male fertility associated with type 2 diabetes mellitus?Q46043078
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasisQ46522437
Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expressionQ46536430
GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartmentQ46785665
Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetesQ46809136
Effects of wortmannin on phosphorylation of PDK1, GSK3-beta, PTEN and expression of Skp2 mRNA after ischemia/reperfusion injury in the mouse kidneyQ46920354
The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and spermQ46968722
Sexual behaviour, sperm quantity and quality after short-term streptozotocin-induced hyperglycaemia in rats.Q46980720
Potential mechanism(s) involved in the regulation of glycogen synthesis by insulinQ48021625
A possible role for the pentose phosphate pathway of spermatozoa in gamete fusion in the mouseQ48923615
Akt1 suppresses radiation-induced germ cell apoptosis in vivo.Q53618826
The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult ratQ69068938
Sperm function and structure and seminal plasma prostanoid concentrations in men with IDDMQ69426104
Gonadal dysfunction in the spontaneously diabetic BB ratQ71773252
Stability of GLUT-1 and GLUT-4 expression in perfused rat muscle stimulated by insulin and exerciseQ72149206
Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacityQ79793582
GSK3: a SHAGGY frog storyQ80120105
Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytesQ80376781
[The influence of diabetes mellitus on male reproductive function: a poorly investigated aspect of male infertility]Q83130963
P433issue1
P304page(s)31-42
P577publication date2012-01-01
P1433published inReproductive SciencesQ7314305
P1476titleDecreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm
P478volume19

Reverse relations

cites work (P2860)
Q34589530Altered of microRNA expression level in oligospermic patients
Q37733021Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells
Q58602155Combining multi-OMICs information to identify key-regulator genes for pleiotropic effect on fertility and production traits in beef cattle
Q36779654Evaluation of subacute bisphenol - A toxicity on male reproductive system
Q38662813GPR55 receptor antagonist decreases glycolytic activity in PANC-1 pancreatic cancer cell line and tumor xenografts
Q36941539Genome-wide differential expression of genes and small RNAs in testis of two different porcine breeds and at two different ages
Q36271468Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice
Q36569497Histological and transcriptome analyses of testes from Duroc and Meishan boars
Q50924267Identification of kinases, phosphatases, and phosphorylation sites in human and porcine spermatozoa.
Q96693542Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K/Akt/mTOR signaling pathway in F1 and F2 generation adult mouse testis
Q42371565Melatonin promotes the proliferation of GC-1 spg cells by inducing metallothionein-2 expression through ERK1/2 signaling pathway activation
Q35923910Modeling the effect of cigarette smoke on hexose utilization in spermatocytes
Q39180467Molecular changes and signaling events occurring in spermatozoa during epididymal maturation.
Q37563586Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis
Q42696023Prenatal bisphenol a exposure leads to reproductive hazards on male offspring via the Akt/mTOR and mitochondrial apoptosis pathways
Q38549842Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function
Q33826216Signaling in sperm: toward a molecular understanding of the acquisition of sperm motility in the mouse epididymis.
Q37686537Significance of microRNA targeted estrogen receptor in male fertility
Q36239755Small RNA sequencing of cryopreserved semen from single bull revealed altered miRNAs and piRNAs expression between High- and Low-motile sperm populations
Q99562973Sphingomyelin Synthase 2 Participate in the Regulation of Sperm Motility and Apoptosis
Q53652464The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.
Q99597158Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes

Search more.