| scholarly article | Q13442814 |
| P50 | author | Brian Hemmings | Q4964012 |
| Jens Frahm | Q102328 | ||
| P2093 | author name string | Takashi Watanabe | |
| Thomas Michaelis | |||
| Oliver Tschopp | |||
| Zhong-Zhou Yang | |||
| Daniela Brodbeck | |||
| Maja Hemmings-Mieszczak | |||
| Bettina A Dummler | |||
| P433 | issue | 13 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 12 | |
| P304 | page(s) | 2943-2954 | |
| P577 | publication date | 2005-06-01 | |
| P1433 | published in | Development | Q3025404 |
| P1476 | title | Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis | |
| P478 | volume | 132 |
| Q38877389 | A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk |
| Q35974696 | A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 |
| Q39015140 | A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer |
| Q34549521 | A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice |
| Q93018670 | A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 |
| Q38218256 | AKT as a therapeutic target in multiple myeloma |
| Q42580351 | AKT in stromal fibroblasts controls invasion of epithelial cells |
| Q47093800 | AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. |
| Q36563578 | AKT signaling in ERBB2-amplified breast cancer |
| Q42511240 | AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation |
| Q35832061 | AKT/GSK3 signaling pathway and schizophrenia |
| Q39255027 | AKT/PKB Signaling: Navigating the Network |
| Q33871498 | AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. |
| Q85964497 | AKT2 is essential to maintain podocyte viability and function during chronic kidney disease |
| Q37405232 | AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. |
| Q36772577 | Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology |
| Q36733736 | Achieving specificity in Akt signaling in cancer |
| Q38824661 | Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling |
| Q36937876 | Advances in behavioral genetics: mouse models of autism |
| Q36815701 | Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS |
| Q39338602 | Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). |
| Q42525511 | Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts |
| Q36917074 | Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents |
| Q34989027 | Akt is required for Stat5 activation and mammary differentiation |
| Q37688855 | Akt isoform specific effects in ovarian cancer progression |
| Q101038777 | Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model |
| Q37800267 | Akt isoforms and glucose homeostasis – the leptin connection |
| Q30494741 | Akt isoforms differentially regulate neutrophil functions |
| Q26851565 | Akt isoforms in vascular disease |
| Q92069609 | Akt modes of stem cell regulation: more than meets the eye? |
| Q43179256 | Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction |
| Q37721192 | Akt signaling in platelets and thrombosis |
| Q42509383 | Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. |
| Q46968816 | Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways". |
| Q34162552 | Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development |
| Q37321172 | Akt1 is critical for acute inflammation and histamine-mediated vascular leakage |
| Q37326916 | Akt2 and SGK3 are both determinants of postnatal hair follicle development. |
| Q59799713 | Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression |
| Q34078703 | Akt2 is involved in loss of epithelial cells and renal fibrosis following unilateral ureteral obstruction |
| Q35291703 | Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells |
| Q36024453 | Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice |
| Q47333934 | Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling |
| Q41626312 | Akt3 is a privileged first responder in isozyme-specific electrophile response. |
| Q30491624 | Akt3 is responsible for the survival and proliferation of embryonic stem cells |
| Q92564624 | Akt3-Mediated Protection Against Inflammatory Demyelinating Disease |
| Q30414943 | All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear. |
| Q41906729 | An Analysis of the Effects and the Molecular Mechanism of Deep Hypothermic Low Flow on Brain Tissue in Mice |
| Q51246446 | Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. |
| Q37691919 | Behavioral effects of developmental methylmercury drinking water exposure in rodents |
| Q36384467 | Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis |
| Q37692074 | Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases |
| Q27851446 | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling |
| Q34401014 | Calcineurin signaling regulates human islet {beta}-cell survival. |
| Q36876219 | Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue |
| Q33654193 | Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes |
| Q52714549 | Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism. |
| Q35906615 | Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain |
| Q36592817 | Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. |
| Q90478449 | Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity |
| Q29614735 | Critical nodes in signalling pathways: insights into insulin action |
| Q37549664 | Current perspectives on Akt Akt-ivation and Akt-ions |
| Q24627067 | De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes |
| Q30647055 | De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly |
| Q35931063 | Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm |
| Q33750723 | Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance |
| Q33301344 | Deletion of PKBalpha/Akt1 affects thymic development |
| Q30529898 | Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex |
| Q35679751 | Delineation of a deletion region critical for corpus callosal abnormalities in chromosome 1q43-q44 |
| Q36388391 | Dichotomy effects of Akt signaling in breast cancer |
| Q33614014 | Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. |
| Q35107276 | Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes |
| Q30415974 | Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice |
| Q33854404 | Distinct roles of the three Akt isoforms in lactogenic differentiation and involution |
| Q34150841 | Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice |
| Q42052161 | Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. |
| Q46765163 | Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin |
| Q39385262 | FOXO transcription factors at the interface of metabolism and cancer |
| Q36444140 | Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders |
| Q37285629 | Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. |
| Q38819941 | Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice |
| Q37305035 | Genetic modelling of the PTEN/AKT pathway in cancer research |
| Q101403007 | Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence |
| Q57833109 | Global Approaches to Understanding Protein Kinase Functions |
| Q37275828 | Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C. |
| Q53116336 | Haploinsufficiency of ZNF238 is associated with corpus callosum abnormalities in 1q44 deletions. |
| Q47800119 | Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines |
| Q44208213 | High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway |
| Q36410278 | Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors. |
| Q48248963 | IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinases |
| Q50486539 | Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice. |
| Q37413596 | Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium |
| Q42136011 | In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis |
| Q41932134 | Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. |
| Q39565163 | Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. |
| Q37099725 | Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT) |
| Q37284683 | Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons |
| Q43224792 | Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube |
| Q35666753 | Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex |
| Q36757048 | Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival |
| Q41774347 | Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation |
| Q34149597 | Intrinsic differences between oral and skin keratinocytes |
| Q46801587 | Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients |
| Q93111529 | Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea |
| Q42948093 | Lentivirus‐mediated expression of insulin‐like growth factor‐I promotes neural stem/precursor cell proliferation and enhances their potential to generate neurons |
| Q41997926 | Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. |
| Q24672400 | Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies |
| Q36753752 | Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease |
| Q35946247 | Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum |
| Q95646188 | Maternal mosaicism underlies the inheritance of a rare germline AKT3 variant which is responsible for megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome in two Roma half-siblings |
| Q34339712 | Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP. |
| Q35382648 | Metabolic circuits in neural stem cells |
| Q64069798 | Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis |
| Q40556837 | Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation. |
| Q27650096 | Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance |
| Q24338593 | NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons |
| Q38292080 | Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice |
| Q90114172 | Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development |
| Q39555624 | Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. |
| Q28505512 | Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death |
| Q33818946 | Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. |
| Q28550274 | Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts |
| Q35595721 | Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice |
| Q42811747 | Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. |
| Q36576524 | On the role of IRS2 in the regulation of functional beta-cell mass |
| Q39126224 | Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. |
| Q47356444 | P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis |
| Q33963861 | PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development |
| Q37974734 | PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. |
| Q91783484 | PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells |
| Q34653250 | PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation |
| Q37310202 | PI3K/Akt: getting it right matters |
| Q29994856 | PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia |
| Q37270423 | PTEN signaling in brain: neuropathology and tumorigenesis. |
| Q39398876 | PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS. |
| Q33791649 | Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis |
| Q41880113 | Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. |
| Q34886884 | Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival. |
| Q35034790 | Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice |
| Q27027815 | Posttranslational regulation of Akt in human cancer |
| Q66680444 | Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors |
| Q36715658 | Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1. |
| Q38687010 | Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis |
| Q48263373 | Protein kinase B (Akt) and mitogen-activated protein kinase p38α in retinal ischemic post-conditioning. |
| Q48768912 | Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes |
| Q50421707 | Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity |
| Q42217599 | Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle. |
| Q29248612 | Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases |
| Q54567807 | Regulation of arterial blood pressure by Akt1-dependent vascular relaxation. |
| Q35176637 | Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity. |
| Q37620749 | Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2. |
| Q37079765 | Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function |
| Q36548467 | Retinoid X Receptor-selective Signaling in the Regulation of Akt/Protein Kinase B Isoform-specific Expression |
| Q36022483 | Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis |
| Q52666361 | Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal. |
| Q55071609 | Role of mTOR Complexes in Neurogenesis. |
| Q37633791 | Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action |
| Q40768338 | S6K Promotes Dopaminergic Neuronal Differentiation Through PI3K/Akt/mTOR-Dependent Signaling Pathways in Human Neural Stem Cells |
| Q54561835 | S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. |
| Q41520294 | Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate |
| Q37293134 | Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1. |
| Q42044656 | Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts. |
| Q33775212 | Signaling specificity in the Akt pathway in biology and disease |
| Q52921010 | Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. |
| Q34234931 | Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons |
| Q43268934 | Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1. |
| Q46762138 | Sublytic C5b-9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy-1 nephritis through TRAF6-mediated PI3K-dependent Akt1 activation |
| Q36475378 | Sugar Consumption Produces Effects Similar to Early Life Stress Exposure on Hippocampal Markers of Neurogenesis and Stress Response |
| Q36588130 | Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling |
| Q45911906 | Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent. |
| Q24297375 | Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2 |
| Q37624534 | Targeting Akt3 signaling in triple-negative breast cancer. |
| Q37872655 | Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs |
| Q38472472 | The Akt isoforms, their unique functions and potential as anticancer therapeutic targets |
| Q37549798 | The Akt kinases: isoform specificity in metabolism and cancer |
| Q36313193 | The Akt/PKB pathway: molecular target for cancer drug discovery |
| Q37294231 | The Akt1 isoform is an essential mediator of ischaemic preconditioning |
| Q24294452 | The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt |
| Q33699378 | The PIK3CA gene as a mutated target for cancer therapy |
| Q36752770 | The beginning of the end: death signaling in early involution |
| Q30494144 | The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia |
| Q37151504 | The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription |
| Q36745379 | The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer |
| Q38740114 | The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. |
| Q37954130 | The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes. |
| Q38175044 | The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development |
| Q41600042 | The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion |
| Q24631438 | Therapeutic Implications of Targeting AKT Signaling in Melanoma |
| Q36772120 | Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis |
| Q24318997 | VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase |
| Q36083845 | Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling |
| Q53051512 | Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent. |
| Q34800160 | mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. |
| Q28252695 | mTOR signaling in tumorigenesis |
| Q26864688 | mTOR-dependent cell survival mechanisms |
| Q37365132 | mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes |
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