| scholarly article | Q13442814 |
| P2093 | author name string | R Parsons | |
| L Simpson | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 29-41 | |
| P577 | publication date | 2001-03-10 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Experimental Cell Research | Q1524289 |
| P1476 | title | PTEN: life as a tumor suppressor | |
| P478 | volume | 264 |
| Q24320313 | A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes |
| Q44176937 | A mathematical model of metabolic insulin signaling pathways |
| Q34236641 | A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis |
| Q40562808 | A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells |
| Q34473669 | A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells. |
| Q35045183 | A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells |
| Q36322321 | A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast |
| Q83350735 | A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 |
| Q33518037 | A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival |
| Q36226730 | Activation of AKT kinases in cancer: implications for therapeutic targeting |
| Q24537734 | Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage |
| Q34688131 | Aging is a deprivation syndrome driven by a germ-soma conflict |
| Q37415110 | Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor |
| Q30479413 | Akt1 governs breast cancer progression in vivo |
| Q37068617 | Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. |
| Q28186818 | Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate |
| Q35750105 | An essential role for protein synthesis in oncogenic cellular transformation |
| Q38780007 | Androgen receptor-related diseases: what do we know? |
| Q97525750 | Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance |
| Q36512334 | Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis |
| Q35943062 | Autism Linked to Increased Oncogene Mutations but Decreased Cancer Rate. |
| Q78392687 | Autocrine TGFbeta supports growth and survival of human breast cancer MDA-MB-231 cells |
| Q35591562 | Autophagy as a therapeutic target in cancer. |
| Q39096483 | BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. |
| Q44435268 | Bcl-xL Mediates a Survival Mechanism Independent of the Phosphoinositide 3-Kinase/Akt Pathway in Prostate Cancer Cells |
| Q36384467 | Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis |
| Q30010282 | CIN85 interacting proteins in B cells-specific role for SHIP-1. |
| Q34470376 | CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells |
| Q38028797 | Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy? |
| Q38330271 | Characterization of nuclear PTEN and its post translational modifications |
| Q37270450 | Class I PI3K in oncogenic cellular transformation. |
| Q35943250 | Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma |
| Q42194172 | Conditional Deletion of PTEN in Peripheral T Cells Augments TCR-Mediated Activation but Does Not Abrogate CD28 Dependency or Prevent Anergy Induction |
| Q36592817 | Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. |
| Q35608397 | Cowden disease and multicystic dysplastic kidney: increased risk of renal cancer? |
| Q36456939 | Cowden syndrome: report of a case with immunohistochemical analysis and review of the literature. |
| Q76400281 | Cowden's syndrome: possible association with testicular seminoma |
| Q28566685 | Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury |
| Q24533405 | Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity |
| Q37064197 | DEMARCATE: Density-based magnetic resonance image clustering for assessing tumor heterogeneity in cancer |
| Q36246003 | Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia |
| Q47198022 | Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease |
| Q35549436 | Destination 'lysosome': a target organelle for tumour cell killing? |
| Q42373821 | Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion |
| Q41952858 | Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators |
| Q28203697 | Direct identification of PTEN phosphorylation sites |
| Q30498163 | Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. |
| Q83853850 | Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD |
| Q35435345 | Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines |
| Q40709512 | Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli |
| Q38910285 | Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells |
| Q35705897 | Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin |
| Q35965439 | Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. |
| Q37284242 | EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors |
| Q40457686 | ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG human glioma cell line. |
| Q41234223 | Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes |
| Q64109900 | Effect of Cetuximab and Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type and Use of as a Possible Biomarker for Treatment Responsiveness |
| Q92081372 | Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology |
| Q37226521 | Emerging biomarkers in glioblastoma |
| Q35861595 | Endometriosis-associated ovarian cancer: a clinicopathologic review |
| Q40647881 | ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002. |
| Q39312236 | Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. |
| Q90706115 | Everolimus inhibits the proliferation and migration of epidermal growth factor receptor-resistant lung cancer cells A549 via regulating the microRNA-4328/phosphatase and tensin homolog signaling pathway |
| Q36611435 | Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing |
| Q52098567 | Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium |
| Q90481635 | FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity |
| Q38200567 | Flavonoids in modulation of cell survival signalling pathways |
| Q28281453 | Flavonoids: modulators of brain function? |
| Q33892868 | Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer |
| Q37797874 | Functional Mechanisms for Human Tumor Suppressors |
| Q40757135 | Functional roles of Akt signaling in mouse skin tumorigenesis. |
| Q33956911 | Functional studies of the mammalian Sac1 phosphoinositide phosphatase |
| Q34783898 | Functions of PI 3-kinase in development of the nervous system |
| Q35143797 | Genes and pathways driving glioblastomas in humans and murine disease models |
| Q34009762 | Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice |
| Q35934455 | Genetics, diagnosis and management of colorectal cancer (Review). |
| Q36823682 | Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma |
| Q35999379 | Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility |
| Q28349476 | Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene |
| Q44306520 | HER2 Ile655Val and PTEN IVS4 polymorphisms in patients with breast cancer. |
| Q24654006 | Hamartomatous polyposis syndromes |
| Q82254205 | High Level of PTEN Expression Is Associated with Low-grade Liver Metastasis and Satisfactory Patient Survival in Pancreatic Cancer |
| Q98945179 | High throughput assessment of biomarkers in tissue microarrays using artificial intelligence: PTEN loss as a proof-of-principle in multi-center prostate cancer cohorts |
| Q40582553 | Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines |
| Q40509516 | Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors |
| Q30884393 | Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. |
| Q35798186 | Immunohistochemistry in melanocytic proliferative lesions |
| Q37479213 | Improving the prognosis for patients with glioblastoma: the rationale for targeting Src. |
| Q35040652 | Incorporation of phosphatase inhibitor in culture prompts growth initiation of isolated non-growing oocytes |
| Q40392033 | Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas |
| Q35043420 | Induction of apoptosis in cancer: new therapeutic opportunities |
| Q36277422 | Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing |
| Q33920097 | Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape |
| Q34766464 | Inhibition of U6 snRNA Transcription by PTEN |
| Q33707662 | Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation |
| Q36023488 | Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms. |
| Q39942925 | Integrin-linked kinase regulates E-cadherin expression through PARP-1. |
| Q43798744 | Interaction of cisplatin, paclitaxel and adriamycin with the tumor suppressor PTEN |
| Q42150387 | Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase. |
| Q28203936 | Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids |
| Q42139067 | Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide |
| Q35560373 | Interplay Between Growth Factor and Nutrient Signaling: Lessons from Drosophila TOR |
| Q38360588 | Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis |
| Q38466996 | Iris Nertschinskia Ethanol Extract Differentially Induces Cytotoxicity in Human Breast Cancer Cells Depending on AKT1/2 Activity |
| Q38075152 | Kinase dysfunction and kinase inhibitors |
| Q34558936 | Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways |
| Q35844528 | Lifelong accumulation of bone in mice lacking Pten in osteoblasts |
| Q33942901 | Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo |
| Q92795407 | Long Non-Coding RNA NONHSAT076754 Promotes Invasion and Metastasis in Epithelial Ovarian Cancer |
| Q90481005 | Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis |
| Q42441080 | Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors |
| Q79327416 | Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression |
| Q39141485 | MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability |
| Q34876968 | MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation |
| Q21245465 | Main roads to melanoma |
| Q37821302 | Medical treatment of unresectable hepatocellular carcinoma: Going beyond sorafenib |
| Q30422427 | Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail |
| Q31055274 | Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection |
| Q42013793 | Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma |
| Q27319993 | Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing |
| Q64124655 | MicroRNA-21 activation of Akt PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite |
| Q36580396 | MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis |
| Q35092291 | Modeling gene-environment interactions in malignant melanoma |
| Q42526732 | Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin. |
| Q35684440 | Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer |
| Q48514271 | Molecular markers of prognosis in astrocytic tumors |
| Q35469289 | Molecular mechanism of size control in development and human diseases |
| Q39021335 | Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway |
| Q35743092 | Multiple cell death pathways as regulators of tumour initiation and progression. |
| Q34996130 | Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field |
| Q78618809 | Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription |
| Q39007820 | Neomorphic mutations create therapeutic challenges in cancer. |
| Q35100996 | New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing |
| Q40445871 | Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. |
| Q42076186 | Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation |
| Q39159757 | Nuclear phosphoinositide regulation of chromatin. |
| Q36337966 | Oncogenic PI3K deregulates transcription and translation |
| Q33610890 | PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. |
| Q37727180 | PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes |
| Q44532177 | PI3K inhibitors changed the p53-induced response of Saos-2 cells from growth arrest to apoptosis |
| Q37032524 | PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects |
| Q38542387 | PI3King the right partner: unique interactions and signaling by p110β. |
| Q37192606 | PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches |
| Q21328702 | PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer |
| Q74257316 | PTEN |
| Q33874805 | PTEN C-terminal deletion causes genomic instability and tumor development |
| Q38759310 | PTEN Promotes Dopaminergic Neuronal Differentiation Through Regulation of ERK-Dependent Inhibition of S6K Signaling in Human Neural Stem Cells |
| Q38048884 | PTEN and Melanomagenesis |
| Q36378575 | PTEN and NEDD4 in Human Breast Carcinoma |
| Q28217868 | PTEN associates with the vault particles in HeLa cells |
| Q30434033 | PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity |
| Q24801835 | PTEN deficiency: a role in mammary carcinogenesis |
| Q34824223 | PTEN hamartoma tumor syndromes. |
| Q37331397 | PTEN in cancer, metabolism, and aging. |
| Q24315949 | PTEN inhibits BMI1 function independently of its phosphatase activity |
| Q34100984 | PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. |
| Q37092758 | PTEN mutation, methylation and expression in breast cancer patients |
| Q40686068 | PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility |
| Q39852386 | PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells |
| Q34258927 | PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat. |
| Q36497447 | PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). |
| Q24529900 | PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex |
| Q37270423 | PTEN signaling in brain: neuropathology and tumorigenesis. |
| Q28181035 | PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms |
| Q90195117 | PTEN, A Target of Microrna-374b, Contributes to the Radiosensitivity of Canine Oral Melanoma Cells |
| Q50977901 | PTEN, Longevity and Age-Related Diseases |
| Q48889007 | PTEN-mediated Akt activation in human neocortex during prenatal development |
| Q39247664 | PTEN/MAPK pathways play a key role in platelet‐activating factor‐induced experimental pulmonary tumor metastasis |
| Q49887901 | PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy. |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q37216319 | PTEN: a default gate-keeping tumor suppressor with a versatile tail |
| Q37270432 | PTEN: a new guardian of the genome. |
| Q60595469 | PTEN: a new twist on β-catenin? |
| Q41529383 | Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury |
| Q38696613 | Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis |
| Q36943633 | Phosphatase and tensin homologue deleted on chromosome 10 |
| Q35542014 | Phosphatases in cell-matrix adhesion and migration |
| Q64988003 | Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage. |
| Q34481485 | Phosphoinositide 3-kinase inhibition in cancer treatment |
| Q33862413 | Phosphoinositide phosphatases in cell biology and disease |
| Q37083611 | Phosphorylation keeps PTEN phosphatase closed for business |
| Q40492430 | Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells |
| Q44467149 | Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions |
| Q42136467 | Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway |
| Q36321798 | Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells |
| Q26748605 | Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG) |
| Q44588841 | Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway |
| Q46843527 | Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q36689092 | Proteomic applications of protein quantification by isotope-dilution mass spectrometry. |
| Q27002565 | PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism |
| Q33882672 | Pten regulates development and lactation in the mammary glands of dairy cows |
| Q34707865 | Pten signaling in gliomas |
| Q34117879 | RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells |
| Q34375626 | REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. |
| Q57975493 | RETRACTED: Regulation of p53: intricate loops and delicate balances |
| Q34369672 | Re-examination of the mechanisms regulating nuclear inositol lipid metabolism |
| Q34646656 | Recent advances in cancer research: mouse models of tumorigenesis |
| Q37024839 | Recent discoveries in the genetics of melanoma and their therapeutic implications |
| Q44236054 | Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas |
| Q26798198 | Redox Regulation in Cancer Stem Cells |
| Q39287073 | Redox control of cytosolic Akt phosphorylation in PTEN null cells |
| Q36266420 | Redox regulation of PI 3-kinase signalling via inactivation of PTEN |
| Q37074281 | Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors |
| Q40426911 | Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA). |
| Q28646911 | Regulation of PTEN transcription by p53 |
| Q33955739 | Regulation of the pentose phosphate pathway in cancer |
| Q40028787 | Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis |
| Q36318226 | Resistance to Trastuzumab in Breast Cancer. |
| Q34554757 | Rho GTPases in transformation and metastasis. |
| Q89921455 | Role of Akt Activation in PARP Inhibitor Resistance in Cancer |
| Q34305706 | Role of serine/threonine protein phosphatase 2A in cancer |
| Q35709778 | S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia |
| Q28510858 | SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts |
| Q49490450 | Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1. |
| Q44843655 | Silencing the PTEN gene is protective against neuronal death induced by human immunodeficiency virus type 1 Tat. |
| Q38845654 | Sox2: regulation of expression and contribution to brain tumors |
| Q38841865 | Specific inhibition of mTOR pathway induces anti-proliferative effect and decreases the hormone secretion in cultured pituitary adenoma cells |
| Q44695743 | Spectrum of somatic EGFR, KRAS, BRAF, PTEN mutations and TTF-1 expression in Brazilian lung cancer patients |
| Q28574362 | Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver |
| Q35544303 | Suppression of PTEN expression by NF-kappa B prevents apoptosis |
| Q37223362 | Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase |
| Q41968721 | Systemic elevation of PTEN induces a tumor-suppressive metabolic state |
| Q33793936 | TESTIN suppresses tumor growth and invasion via manipulating cell cycle progression in endometrial carcinoma |
| Q37175517 | TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells |
| Q42961775 | TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer |
| Q39943672 | TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells |
| Q43745119 | TOJ3, a v-jun target with intrinsic oncogenic potential, is directly regulated by Jun via a novel AP-1 binding motif. |
| Q28364566 | TPIP: a novel phosphoinositide 3-phosphatase |
| Q38208314 | Targeting PI3K/Akt/mTOR Signaling in Cancer |
| Q28201363 | Targeting RAS signalling pathways in cancer therapy |
| Q34988494 | Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling |
| Q36379394 | Targeting the PTPome in human disease |
| Q34525357 | The CD28 signaling pathway regulates glucose metabolism |
| Q37165194 | The Critical Role of PPARgamma in Human Malignant Melanoma |
| Q43848062 | The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling |
| Q36137628 | The PTEN Tumor Suppressor Forms Homodimers in Solution. |
| Q34579435 | The PTEN/NRF2 axis promotes human carcinogenesis |
| Q34405519 | The activation of Akt/PKB signaling pathway and cell survival. |
| Q38693728 | The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis |
| Q42470250 | The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. |
| Q28083829 | The critical role of Akt in cardiovascular function |
| Q28253741 | The emerging roles of forkhead box (Fox) proteins in cancer |
| Q81241238 | The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans |
| Q37737145 | The impact of concomitant genomic alterations on treatment outcome for trastuzumab therapy in HER2-positive gastric cancer |
| Q37292416 | The interactions of flavonoids within neuronal signalling pathways |
| Q37290512 | The molecular genetics of breast cancer and targeted therapy |
| Q34973870 | The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. |
| Q28645742 | The protein kinase B/Akt signalling pathway in human malignancy |
| Q38736271 | The rise and fall of insulin signaling in Alzheimer's disease |
| Q46732973 | The role of phosphatase and tensin homolog in drug‐induced gingival overgrowth |
| Q40601438 | The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif |
| Q35096803 | Therapeutic potential of phosphoinositide 3-kinase inhibitors. |
| Q46601914 | Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma |
| Q38871798 | Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway |
| Q37691234 | Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways |
| Q95329144 | Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes |
| Q35019684 | Translational control of gene expression and disease |
| Q36630127 | Trastuzumab-Resistant Luminal B Breast Cancer Cells Show Basal-Like Cell Growth Features Through NF-κB-Activation |
| Q37218978 | Treatment of recurrent metastatic head and neck cancer: focus on cetuximab |
| Q38708792 | Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro |
| Q36252762 | Tumor suppressor genetics |
| Q35679775 | Tumour-suppressor function in the nervous system |
| Q36404118 | Tumours and tremors: how PTEN regulation underlies both |
| Q38195673 | Understanding Lunasin's biology and potential as a cancer therapeutic by utilizing Drosophila genetics |
| Q37034487 | Understanding signaling cascades in melanoma |
| Q40328533 | Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli |
| Q37058923 | Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies. |
| Q35313400 | Voltage-sensing phosphatase modulation by a C2 domain |
| Q102320357 | WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer |
| Q80703208 | [Acral keratoses and inverted follicular keratosis presenting Cowden disease] |
| Q73401767 | [Molecular diagnostics of prostate cancer] |
| Q30160821 | grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice |
| Q35560399 | mTOR as a Positive Regulator of Tumor Cell Responses to Hypoxia |
| Q37941273 | mTOR signaling in disease |
| Q33572268 | miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. |
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