| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1028071245 |
| P356 | DOI | 10.1038/SJ.ONC.1205032 |
| P698 | PubMed publication ID | 11791176 |
| P5875 | ResearchGate publication ID | 11567795 |
| P50 | author | Paloma Pérez | Q42521893 |
| Jesus M. Paramio | Q43100805 | ||
| J. Silvio Gutkind | Q52088940 | ||
| P2093 | author name string | Thomas J Slaga | |
| Carmen Segrelles | |||
| Mirentxu Santos | |||
| Sergio Ruiz | |||
| Jesús Martínez | |||
| Fernando Larcher | |||
| Jose L Jorcano | |||
| Cristina Murga | |||
| Irina V Budunova | |||
| P2860 | cites work | Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest | Q24548285 |
| Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase | Q24682825 | ||
| Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) | Q24685138 | ||
| PTEN: life as a tumor suppressor | Q28203431 | ||
| Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343 | Q28213632 | ||
| Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta | Q28255046 | ||
| Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization | Q28290083 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression | Q28595042 | ||
| Role of translocation in the activation and function of protein kinase B | Q28609902 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway | Q29614258 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction | Q29618388 | ||
| PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model | Q32069431 | ||
| Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells | Q32084034 | ||
| Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors | Q33778600 | ||
| The multiple roles of PTEN in tumor suppression | Q33849727 | ||
| Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway | Q33884776 | ||
| The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. | Q33911629 | ||
| Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis | Q34162269 | ||
| Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions | Q34295503 | ||
| Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo | Q35207717 | ||
| PTEN controls tumor-induced angiogenesis | Q35282160 | ||
| A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis | Q36530335 | ||
| Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells | Q36552538 | ||
| Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets | Q36716953 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Modulation of cell proliferation by cytokeratins K10 and K16 | Q39445342 | ||
| Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression | Q40877541 | ||
| Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene | Q40896708 | ||
| PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. | Q40911230 | ||
| Expression of the integrin-linked kinase (ILK) in mouse skin: loss of expression in suprabasal layers of the epidermis and up-regulation by erbB-2. | Q42459989 | ||
| The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells | Q42481082 | ||
| The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development | Q42492007 | ||
| A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. | Q42803236 | ||
| Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines | Q42806228 | ||
| Multiple ras effector pathways contribute to G(1) cell cycle progression | Q42812883 | ||
| Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol | Q42818060 | ||
| Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells | Q43539828 | ||
| Ras activation of phosphatidylinositol 3-kinase and Akt. | Q43635848 | ||
| Early expression of type I K13 keratin in the progression of mouse skin papillomas. | Q44869872 | ||
| Increasing complexity of the Ras signaling pathway | Q47762067 | ||
| Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. | Q47828172 | ||
| Increasing complexity of Ras signaling. | Q53429989 | ||
| Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas. | Q53494174 | ||
| Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1 | Q57562833 | ||
| Increased expression of mutated Ha-ras during premalignant progression in SENCAR mouse skin | Q73177480 | ||
| Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27 | Q73959940 | ||
| Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin | Q77540467 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 53-64 | |
| P577 | publication date | 2002-01-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Functional roles of Akt signaling in mouse skin tumorigenesis | |
| P478 | volume | 21 |
| Q36386230 | A novel tumor suppressor network in squamous malignancies |
| Q36237554 | A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer |
| Q41593135 | AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors. |
| Q35046899 | Activation of the PI3K/Akt pathway and chemotherapeutic resistance |
| Q42592447 | Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. |
| Q42453787 | Akt signaling leads to stem cell activation and promotes tumor development in epidermis. |
| Q38288770 | Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice |
| Q48021975 | An ErbB receptor-mediated AP-1 regulatory network is modulated by STAT3 and c-MYC during calcium-dependent keratinocyte differentiation |
| Q80955284 | Analysis of activated EGFR signalling pathways and their relation to laminin-5 gamma2 chain expression in oral squamous cell carcinoma (OSCC) |
| Q34157973 | Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. |
| Q53346447 | Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. |
| Q35955155 | Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis. |
| Q39935548 | Complexity of VEGF responses in skin carcinogenesis revealed through ex vivo assays based on a VEGF-A null mouse keratinocyte cell line. |
| Q43180595 | Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease |
| Q35356038 | Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors |
| Q36325901 | Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling |
| Q39760533 | Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo |
| Q39126378 | Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors |
| Q46001604 | Cyclin D1-induced proliferation is independent of beta-catenin in head and neck cancer. |
| Q60644300 | Deletion of the N-terminus of IKKγ induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway |
| Q33917709 | Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation |
| Q37689011 | Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development. |
| Q88909501 | Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis |
| Q49610989 | Dual Effects of High Protein Diet on Mouse Skin and Colonic Inflammation. |
| Q37560349 | Dual modulation of JNK and Akt signaling pathways by chaetoglobosin K in human lung carcinoma and ras-transformed epithelial cells |
| Q46096656 | EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin D1 and COX-2 expression |
| Q36103054 | EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy |
| Q35999401 | EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours |
| Q30524175 | Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten |
| Q36097144 | Emerging therapies in pancreas cancer |
| Q35943724 | Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. |
| Q23911301 | Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-Kinase/Akt signaling pathway in mouse epidermal cells |
| Q42462859 | Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis |
| Q37774602 | Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. |
| Q42484138 | Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin |
| Q47613853 | Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC. |
| Q33707315 | Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice |
| Q28589635 | Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis |
| Q36180739 | In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue |
| Q38584436 | K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma. |
| Q42547962 | LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis |
| Q27009209 | Lessons learned from next-generation sequencing in head and neck cancer |
| Q37723939 | Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways |
| Q37570847 | Metformin inhibits skin tumor promotion in overweight and obese mice |
| Q40552646 | Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. |
| Q34489245 | Modulating the structure of EGFR with UV light: new possibilities in cancer therapy |
| Q34769445 | Modulation of protein kinase signaling cascades by palytoxin |
| Q46772716 | Molecular determinants of Akt-induced keratinocyte transformation |
| Q40013923 | Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression |
| Q35838744 | New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers |
| Q42714145 | Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1. |
| Q38294207 | Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin--AP-1 and C/EBP as potential upstream targets |
| Q28483822 | Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish |
| Q37429785 | PTEN: new insights into its regulation and function in skin cancer |
| Q35585553 | Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis |
| Q36390329 | Pathways involved in sunburn cell formation: deregulation in skin cancer |
| Q38684394 | Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas. |
| Q46843527 | Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes |
| Q43103589 | Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo |
| Q35106935 | Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention |
| Q33705425 | Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate |
| Q37287092 | Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes |
| Q45903019 | SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway. |
| Q33222107 | SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity |
| Q44108788 | Selective ablation of glucocorticoid receptor in mouse keratinocytes increases susceptibility to skin tumorigenesis |
| Q38187197 | Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients |
| Q36249542 | TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development |
| Q37713024 | Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development |
| Q34481735 | The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. |
| Q38008348 | The EMILIN/Multimerin family. |
| Q34229795 | The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models |
| Q35814450 | The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. |
| Q36414431 | The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior |
| Q42518511 | The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis |
| Q39297991 | The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. |
| Q38203467 | The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact |
| Q36219713 | The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck. |
| Q37329206 | The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development |
| Q90454478 | The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis |
| Q24313064 | UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes |
| Q47132106 | UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation |
| Q38340621 | Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation |
| Q92783226 | Wnt Signaling Pathways in Keratinocyte Carcinomas |
| Q37210960 | [18F]fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy. |
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