Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis

scientific article published on 18 March 2008

Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2353/AJPATH.2008.070892
P932PMC publication ID2276430
P698PubMed publication ID18349128
P5875ResearchGate publication ID5503599

P2093author name stringFrank R Jirik
Shigeki Tsutsui
Trina A Johnson
P2860cites workTissue- and site-specific DNA recombination in transgenic miceQ21999077
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
Modelling T-cell memory by genetic marking of memory T cells in vivoQ28137842
PTEN: life as a tumor suppressorQ28203431
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitisQ81129297
Immunology of multiple sclerosisQ81531267
Pten is essential for embryonic development and tumour suppressionQ28509238
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumorsQ29616203
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.Q34300766
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).Q34381917
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient miceQ34381923
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ TregsQ34997285
The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisalQ35702792
Do phosphoinositide 3-kinases direct lymphocyte navigation?Q35753100
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE miceQ35940569
Regulatory functions of CD8+CD28– T cells in an autoimmune disease modelQ36001202
Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectorsQ36017999
The role of CD8(+) T cells in multiple sclerosis and its animal modelsQ36107655
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?Q36173589
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reactionQ36368672
A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosisQ36376307
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisQ36384467
The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signalingQ36403817
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.Q36457107
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.Q40196116
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.Q41377207
Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosisQ44002202
A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.Q44762699
Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.Q46039047
p27Kip1 is required for PTEN-induced G1 growth arrest.Q46585082
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific mannerQ46952728
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos diseaseQ47198015
Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesionsQ48338419
A transgenic mouse model genetically tags all activated CD8 T cells.Q52006066
Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1.Q52023151
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.Q54150165
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.Q54650311
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral ToleranceQ57185252
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- miceQ57272679
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic LesionsQ72773066
Impaired Fas response and autoimmunity in Pten+/- miceQ73019160
Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 miceQ73966732
Experimental autoimmune encephalomyelitis mediated by CD8+ T cellsQ80005390
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTENQ80283949
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)980-992
P577publication date2008-03-18
P1433published inThe American Journal of PathologyQ4744259
P1476titleAntigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis
P478volume172

Reverse relations

cites work (P2860)
Q37711026Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination
Q34253257Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
Q38732326Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice