| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1045883201 |
| P356 | DOI | 10.1038/SJ.LEU.2403044 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/sj.leu.2403044 |
| P8608 | Fatcat ID | release_46vsukwmpbhnnlh5o2glkx6ze4 |
| P698 | PubMed publication ID | 12970779 |
| P5875 | ResearchGate publication ID | 10570173 |
| P2093 | author name string | A M Billi | |
| A M Martelli | |||
| L Cocco | |||
| L Manzoli | |||
| P L Tazzari | |||
| G Tabellini | |||
| R Bortul | |||
| A Ruggeri | |||
| R Conte | |||
| P2860 | cites work | Phosphorylation and activation of p70s6k by PDK1 | Q24323433 |
| Synthesis and function of 3-phosphorylated inositol lipids | Q28200755 | ||
| PTEN: life as a tumor suppressor | Q28203431 | ||
| Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 | Q28283323 | ||
| Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 | Q28567633 | ||
| p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD | Q28592766 | ||
| The protein kinase B/Akt signalling pathway in human malignancy | Q28645742 | ||
| The biochemistry of apoptosis | Q29547741 | ||
| Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia | Q29547900 | ||
| Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. | Q30759657 | ||
| SHIPs ahoy | Q33785109 | ||
| Acute lymphoblastic leukemia in children | Q33845166 | ||
| Induction of apoptosis by cancer chemotherapy. | Q33876771 | ||
| Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. | Q34099883 | ||
| How do inhibitory phosphatases work? | Q34158953 | ||
| Molecular signals in anti-apoptotic survival pathways. | Q34177539 | ||
| Ten years of protein kinase B signalling: a hard Akt to follow | Q34432885 | ||
| The modular phosphorylation and activation of p70s6k. | Q34434557 | ||
| 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro | Q34452063 | ||
| Insulin signaling pathways in time and space. | Q34534983 | ||
| Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy | Q34569709 | ||
| Acute myeloid leukemia in adults | Q34677725 | ||
| Retinoic acid resistance in acute promyelocytic leukemia | Q34926648 | ||
| Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP. | Q39700468 | ||
| Flow cytometric detection of total and serine 473 phosphorylated Akt. | Q40636307 | ||
| Etoposide-mediated deregulation of the G2M checkpoint in myeloid leukaemic cell lines results in loss of cell survival | Q40684678 | ||
| Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors | Q40691514 | ||
| Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma | Q40702649 | ||
| Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. | Q40709933 | ||
| The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells | Q40788345 | ||
| Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders | Q40857867 | ||
| Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. | Q40887186 | ||
| Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia | Q40895282 | ||
| Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway | Q40910700 | ||
| Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation. | Q43615277 | ||
| Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. | Q43625664 | ||
| TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications | Q43684721 | ||
| Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer | Q43761459 | ||
| Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou | Q43847794 | ||
| Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells | Q44083882 | ||
| Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications | Q44098361 | ||
| Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia | Q44279382 | ||
| Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. | Q44293983 | ||
| Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation | Q44319730 | ||
| The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines. | Q54090437 | ||
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies | Q57591287 | ||
| Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells | Q61727668 | ||
| Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation | Q72134428 | ||
| Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Ad | Q72377470 | ||
| 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth | Q74217711 | ||
| P433 | issue | 9 | |
| P921 | main subject | chemotherapy | Q974135 |
| tretinoin | Q29417 | ||
| leukemia | Q29496 | ||
| P304 | page(s) | 1794-1805 | |
| P577 | publication date | 2003-09-01 | |
| P1433 | published in | Leukemia | Q6534498 |
| P1476 | title | A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells | |
| P478 | volume | 17 |
| Q33573322 | AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression |
| Q27309773 | AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. |
| Q36226730 | Activation of AKT kinases in cancer: implications for therapeutic targeting |
| Q40295205 | Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells |
| Q39845179 | Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis |
| Q47093662 | Akt inhibition improves long-term tumour control following radiotherapy by altering the microenvironment |
| Q35023909 | Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death |
| Q40488966 | Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway |
| Q37620676 | Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L) |
| Q37680195 | Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways |
| Q39681548 | Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro |
| Q38841544 | Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways |
| Q46575039 | Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). |
| Q33279222 | Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents |
| Q45029000 | Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry |
| Q44820345 | Experimental evidence for the limiting role of enzymatic reactions in chemoattractant-induced pseudopod extension in human neutrophils |
| Q46845164 | Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients |
| Q41885536 | GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation |
| Q35661283 | Gambogenic acid alters chemosensitivity of breast cancer cells to Adriamycin |
| Q40054910 | Gene transfer of CD40-ligand to dendritic cells stimulates interferon-gamma production to induce growth arrest and apoptosis of tumor cells |
| Q90163316 | Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway |
| Q38698556 | HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6 |
| Q39662047 | Hedgehog signaling maintains chemoresistance in myeloid leukemic cells. |
| Q40485863 | Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes |
| Q36292039 | Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms |
| Q37613364 | Modulating the tumor microenvironment to increase radiation responsiveness |
| Q38798466 | Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway |
| Q47637698 | Molecular mechanism of violacein-mediated human leukemia cell death |
| Q40492173 | Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway |
| Q33882138 | Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain |
| Q48306335 | Oncophosphosignaling Favors a Glycolytic Phenotype in Human Drug Resistant Leukemia |
| Q40343052 | Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo |
| Q40355706 | PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis |
| Q39924786 | PI3K/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells |
| Q54630382 | PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells. |
| Q83868886 | Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation |
| Q40488705 | Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells |
| Q36461618 | Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
| Q34685805 | Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin. |
| Q40241184 | Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions |
| Q35743123 | Role of mitochondrial membrane permeabilization in apoptosis and cancer |
| Q39514532 | Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration |
| Q34365708 | Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk |
| Q34291312 | TRAIL in cancer therapy: present and future challenges |
| Q37322648 | TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5 |
| Q33493174 | Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia |
| Q36742629 | Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations |
| Q21129297 | The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis |
| Q37278043 | The TRAIL apoptotic pathway in cancer onset, progression and therapy |
| Q39649197 | The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies. |
| Q35814450 | The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. |
| Q56995355 | The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion |
| Q37476789 | The role of autophagy in sensitizing malignant glioma cells to radiation therapy |
| Q35838573 | The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses |
| Q40291978 | The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells |
| Q38056012 | Trimming the fat: obesity and hematopoietic cell transplantation |
| Q34568521 | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK |
| Q34227256 | Zebrafish screen identifies novel compound with selective toxicity against leukemia. |
| Q40208269 | t(8;21) acute myeloid leukaemia cells are dependent on vascular endothelial growth factor (VEGF)/VEGF receptor type2 pathway and phosphorylation of Akt. |
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