The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans

scientific article published on 21 June 2019

The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.30697
P932PMC publication ID7195156
P698PubMed publication ID31062368

P50authorLi CheQ61160006
Xin ChenQ88073652
Antonio CiglianoQ43122575
P2093author name stringXi Chen
Shu Zhang
Meng Xu
Diego F Calvisi
Pin Liu
Frank Dombrowski
Matthias Evert
Yu Qiao
Zhong Xu
Katja Evert
Silvia Ribback
Runze Shang
Rosa M Pascale
P2860cites workGlucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase ActivitiesQ46763707
Targets for immunotherapy of liver cancer.Q47965755
mTOR Signaling in Growth, Metabolism, and Disease.Q54144950
Hepatocellular carcinomaQ57756376
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting TherapyQ64274877
A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes MelliitusQ70314155
EverolimusQ87733396
Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?Q27025083
Sorafenib in advanced hepatocellular carcinomaQ27861075
MYC on the path to cancerQ29619979
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4EQ33980041
Oncogene-specific formation of chemoresistant murine hepatic cancer stem cellsQ34233172
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerQ34357796
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trialQ34663499
MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductaseQ34687185
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancerQ34990362
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppressionQ36248716
Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC CellsQ36899877
Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.Q37038522
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle developmentQ37497352
Akt-mediated foxo1 inhibition is required for liver regeneration.Q37525730
Hydrodynamic transfection for generation of novel mouse models for liver cancer researchQ38183539
Current treatment strategies for inhibiting mTOR in cancerQ38286529
Akt2 is required for hepatic lipid accumulation in models of insulin resistance.Q38349186
Signaling crosstalk between the mTOR complexesQ38700659
Comprehensive and Integrative Genomic Characterization of Hepatocellular CarcinomaQ38722204
TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implicationQ38726203
TORC2 Structure and FunctionQ38830534
mTORC1 signaling and the metabolic control of cell growthQ39243905
Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivoQ39491650
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Q39656536
Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesityQ40313842
Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascadeQ42468960
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1Q42592859
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.Q45870005
A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Q46519493
P433issue5
P304page(s)1600-1613
P577publication date2019-06-21
P1433published inHepatologyQ15724398
P1476titleThe mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans
P478volume70

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cites work (P2860)
Q90383817Experimental Models to Define the Genetic Predisposition to Liver Cancer
Q94566583Role of the mTOR pathway in liver cancer: from molecular genetics to targeted therapies
Q89537463Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma

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