mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome.

scientific article

mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LABINVEST.2011.135
P698PubMed publication ID21876538
P5875ResearchGate publication ID51604460

P2093author name stringKatsuhiko Asanuma
Kunimasa Yan
Yoshimichi Sai
Yoshihiro Akimoto
Akihiko Kudo
Noriko Ito
Ken-Ichi Miyamoto
Hitoshi Takenaka
Yukino Nishibori
Yugo Ito
Hisashi Takagi
P2860cites workMizoribine Corrects Defective Nephrin Biogenesis by Restoring Intracellular Energy BalanceQ62392677
Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivativeQ73378576
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EQ24301780
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndromeQ24314612
Structure of the gene for congenital nephrotic syndrome of the finnish type (NPHS1) and characterization of mutationsQ24540018
Amino acid transporter LAT3 is required for podocyte development and functionQ24649770
N-linked glycosylation is critical for the plasma membrane localization of nephrinQ28215172
Upstream and downstream of mTORQ28277365
ER chaperones in mammalian development and human diseasesQ28300625
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndromeQ28569367
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionQ29617473
AMP-activated protein kinase: the energy charge hypothesis revisitedQ33183179
Quality and quantity control at the endoplasmic reticulumQ34090425
Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsinQ34405985
Orchestrating the unfolded protein response in health and diseaseQ35001604
TOR signaling: an odyssey from cellular stress to the cell growth machineryQ36050780
Protein quality control in the early secretory pathwayQ36446833
Expanding mTOR signalingQ36902840
Minimal change nephropathy and focal segmental glomerulosclerosisQ36978935
The endoplasmic reticulum and the unfolded protein responseQ37006310
Endoplasmic reticulum stress responsesQ37014237
Endoplasmic reticulum: nutrient sensor in physiology and pathologyQ37435215
Endoplasmic reticulum stress and renal diseaseQ37512291
Endoplasmic reticulum stress in proteinuric kidney diseaseQ37610753
mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytesQ39914641
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseasesQ40305946
Amino acid availability regulates p70 S6 kinase and multiple translation factorsQ41913722
Comparative analysis of adverse events requiring suspension of mTOR inhibitors: everolimus versus sirolimus.Q42849612
Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?Q43293883
Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trialQ46155747
Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injuryQ46465778
Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.Q53940416
The podocyte as a direct target of immunosuppressive agentsQ58177753
P433issue11
P304page(s)1584-1595
P577publication date2011-08-29
P1433published inLaboratory InvestigationQ6467260
P1476titlemTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome.
P478volume91

Reverse relations

cites work (P2860)
Q85964497AKT2 is essential to maintain podocyte viability and function during chronic kidney disease
Q36572270Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition
Q38017937Childhood nephrotic syndrome--current and future therapies
Q34571047Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis
Q38073952Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
Q36746091Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.
Q36956916Focal segmental glomerulosclerosis in association with neurofibromatosis type 1: a case report and proposed molecular pathways
Q91045235Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1α axis regulates ER stress during high-carbohydrate feeding
Q95660603Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis
Q54340348Mammalian target of rapamycin complex 1 activation in podocytes promotes cellular crescent formation.
Q39245624Metabolism and homeostasis in the kidney: metabolic regulation through insulin signaling in the kidney
Q47574932Prohibitin Signaling at the Kidney Filtration Barrier.
Q27315815Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling
Q38012182Proteinuria after kidney transplantation
Q38206090Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease
Q58795372Puromycin aminonucleoside triggers apoptosis in podocytes by inducing endoplasmic reticulum stress
Q34718418Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury
Q38914374Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.
Q37995467The struggle for energy in podocytes leads to nephrotic syndrome
Q36407247Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis
Q38985872USP40 gene knockdown disrupts glomerular permeability in zebrafish
Q36100123Understanding the mechanisms of proteinuria: therapeutic implications
Q51287053Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.
Q51126964Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.
Q38185017mTOR controls kidney epithelia in health and disease

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