Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.

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Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.152405
P8608Fatcat IDrelease_huwe6a7b7nh3zmfl4m6i2bjx6e
P932PMC publication ID3069456
P698PubMed publication ID21300805

P2093author name stringJin Zhang
Jean Tang
Jake Chen
En Luo
Qisheng Tu
Lily Q Dong
Eileen Saunders
P2860cites workAdiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophagesQ24290146
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3Q24309262
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and functionQ24318702
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GSK-3: tricks of the trade for a multi-tasking kinaseQ24624069
AKT/PKB signaling: navigating downstreamQ24657857
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaQ24669877
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeysQ43596028
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in miceQ43726502
Direct action of 1,25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral conditionQ44958266
Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursorsQ45151645
The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men.Q46629440
Adiponectin as a novel determinant of bone mineral density and visceral fat.Q47447230
Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophagesQ47735588
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.Q51555890
Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam studyQ57388831
Low Body Mass Index Is an Important Risk Factor for Low Bone Mass and Increased Bone Loss in Early Postmenopausal WomenQ58971952
Obesity in the new millenniumQ59070727
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblastQ64378725
Periodontal disease and NIDDM in Pima IndiansQ68550131
Obesity and periodontitisQ77096696
Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathwayQ80331559
Adiponectin inhibits induction of TNF-alpha/RANKL-stimulated NFATc1 via the AMPK signalingQ80507069
Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathwaysQ83106710
Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob ratsQ83979831
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivoQ24678206
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factorQ27748941
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Q28511676
Protein kinase B alpha/Akt1 regulates placental development and fetal growthQ28588076
Leptin regulation of bone resorption by the sympathetic nervous system and CARTQ28589974
Obesity and the regulation of energy balanceQ30080025
Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.Q30579244
The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral densityQ30948265
Bone and body composition of children and adolescents with repeated forearm fracturesQ33227423
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and womenQ33231119
Adiponectin is a negative regulator of bone mineral and bone strength in growing miceQ33375330
Systemically transplanted bone marrow stromal cells contributing to bone tissue regenerationQ33689241
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemiaQ33946056
Regulation of nuclear localization during signalingQ34219442
Adiponectin differentially regulates cytokines in porcine macrophagesQ34307305
Structure, regulation and function of PKB/AKT--a major therapeutic targetQ35692051
Relationship of obesity with osteoporosisQ35792568
Increased adipose tissue in male and female estrogen receptor-alpha knockout miceQ35823619
Adipose tissue, adipokines, and inflammationQ36114223
Obesity, inflammation, and periodontal diseaseQ36798998
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in boneQ36926972
Cross-susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective.Q36938546
Targeted overexpression of BSP in osteoclasts promotes bone metastasis of breast cancer cellsQ37152195
Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in miceQ37200578
The relationship between adipokines, body composition, and bone density in men with chronic obstructive pulmonary diseaseQ37284896
Sex differences in the association between adiponectin and BMD, bone loss, and fractures: the Rancho Bernardo studyQ37469372
Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cellsQ39838900
In vitro and in vivo effects of adiponectin on boneQ39858264
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinaseQ40020653
Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitansQ40210296
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expressionQ40343195
BSP and RANKL induce osteoclastogenesis and bone resorption synergisticallyQ40390865
Autoregulation of bone sialoprotein gene in pre-osteoblastic and non-osteoblastic cellsQ40578601
The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cellsQ40599606
AdipoQ is a novel adipose-specific gene dysregulated in obesityQ42813232
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinQ42826174
Haploinsufficiency of Runx2 results in bone formation decrease and different BSP expression pattern changes in two transgenic mouse modelsQ42921184
Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitusQ43203328
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)12542-12553
P577publication date2011-02-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleAdiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.
P478volume286

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cites work (P2860)
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Q36505689Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts
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