| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/S41580-018-0015-0 |
| P698 | PubMed publication ID | 29858604 |
| P50 | author | Pier Paolo Pandolfi | Q7191735 |
| Ming Chen | Q56903480 | ||
| P2093 | author name string | Yu-Ru Lee | |
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| Hallmarks of Cancer: The Next Generation | Q22252312 | ||
| Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | Q22253438 | ||
| Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 | Q22253866 | ||
| Phosphorylation of the PTEN tail regulates protein stability and function | Q22254305 | ||
| The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation | Q24290417 | ||
| NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN | Q24292919 | ||
| Ubiquitination regulates PTEN nuclear import and tumor suppression | Q24292946 | ||
| Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function | Q24295164 | ||
| K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking | Q24295450 | ||
| PCAF modulates PTEN activity | Q24296629 | ||
| SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth | Q24309283 | ||
| Rak functions as a tumor suppressor by regulating PTEN protein stability and function | Q24312999 | ||
| X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization | Q24314543 | ||
| Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity | Q24316318 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner | Q24337323 | ||
| AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain | Q24536241 | ||
| Understanding the Warburg effect: the metabolic requirements of cell proliferation | Q24604760 | ||
| A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands | Q24606333 | ||
| MicroRNAs: target recognition and regulatory functions | Q24609584 | ||
| Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a | Q24613036 | ||
| Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 | Q24623513 | ||
| In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma | Q24629400 | ||
| Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs | Q24629589 | ||
| A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Q24629627 | ||
| A coding-independent function of gene and pseudogene mRNAs regulates tumour biology | Q24632651 | ||
| mTOR: from growth signal integration to cancer, diabetes and ageing | Q24633662 | ||
| The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization | Q24650856 | ||
| Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes | Q24651802 | ||
| Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas | Q24652219 | ||
| AKT/PKB signaling: navigating downstream | Q24657857 | ||
| Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation | Q24673801 | ||
| Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis | Q24681977 | ||
| Pten dose dictates cancer progression in the prostate | Q24791909 | ||
| Cellular senescence in aging and age-related disease: from mechanisms to therapy | Q26773500 | ||
| K11-linked ubiquitin chains as novel regulators of cell division | Q26851677 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| The ubiquitin system | Q27860803 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| On the Origin of Cancer Cells | Q27861025 | ||
| Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis | Q28117749 | ||
| Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers | Q28145813 | ||
| PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism | Q28238905 | ||
| PTEN is a protein tyrosine phosphatase for IRS1 | Q28239790 | ||
| Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas | Q34254614 | ||
| Pten positively regulates brown adipose function, energy expenditure, and longevity | Q34260134 | ||
| Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation | Q34298595 | ||
| p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. | Q34378916 | ||
| Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas | Q34380511 | ||
| Regulation of PTEN by Rho small GTPases | Q34406790 | ||
| Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. | Q34547450 | ||
| The insulin signalling pathway | Q34590855 | ||
| A continuum model for tumour suppression | Q34631552 | ||
| PTEN acetylation modulates its interaction with PDZ domain | Q34817146 | ||
| Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth | Q34981637 | ||
| CREB is a novel nuclear target of PTEN phosphatase | Q35019216 | ||
| Subtle variations in Pten dose determine cancer susceptibility | Q35055350 | ||
| On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN) | Q35064223 | ||
| SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells | Q35064623 | ||
| In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics | Q35072024 | ||
| Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia | Q35666277 | ||
| Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 | Q35729814 | ||
| PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers | Q35747653 | ||
| Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors | Q35810225 | ||
| The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation | Q35939892 | ||
| Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas | Q36134504 | ||
| The PTEN Tumor Suppressor Forms Homodimers in Solution. | Q36137628 | ||
| Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy | Q36164945 | ||
| Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. | Q36212896 | ||
| Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals | Q36238390 | ||
| Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression | Q36248716 | ||
| Txnip balances metabolic and growth signaling via PTEN disulfide reduction | Q36499261 | ||
| Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer | Q36698824 | ||
| PTEN enters the nuclear age. | Q36705731 | ||
| PTEN, more than the AKT pathway | Q36753139 | ||
| Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth | Q36761252 | ||
| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia | Q37009642 | ||
| Tenets of PTEN tumor suppression | Q37154214 | ||
| MC1R is a potent regulator of PTEN after UV exposure in melanocytes | Q37220171 | ||
| Understanding PTEN regulation: PIP2, polarity and protein stability | Q37270444 | ||
| The role of PTEN signaling perturbations in cancer and in targeted therapy | Q37270446 | ||
| Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer | Q37317395 | ||
| Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress | Q37380066 | ||
| Pten in stromal fibroblasts suppresses mammary epithelial tumours | Q37399478 | ||
| Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways | Q37425090 | ||
| The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells | Q37452295 | ||
| WWP2 is an E3 ubiquitin ligase for PTEN. | Q37588182 | ||
| Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers | Q37627634 | ||
| Deubiquitylation and stabilization of PTEN by USP13 | Q37633952 | ||
| MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN. | Q37706328 | ||
| PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription | Q37733825 | ||
| Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex | Q28244856 | ||
| The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity | Q28269344 | ||
| A secreted PTEN phosphatase that enters cells to alter signaling and survival | Q28292188 | ||
| The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway | Q28298223 | ||
| A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. | Q28305284 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration | Q28384823 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Essential role for nuclear PTEN in maintaining chromosomal integrity | Q28513781 | ||
| Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs | Q28564702 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination | Q28591752 | ||
| Regulation of PTEN transcription by p53 | Q28646911 | ||
| MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer | Q29547523 | ||
| Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 | ||
| Reversible inactivation of the tumor suppressor PTEN by H2O2 | Q29615204 | ||
| The functions and regulation of the PTEN tumour suppressor | Q29615536 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells | Q29616552 | ||
| Nonproteolytic functions of ubiquitin in cell signaling | Q29617294 | ||
| Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis | Q29617613 | ||
| The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes | Q29619577 | ||
| Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction | Q29619822 | ||
| Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. | Q29977747 | ||
| Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. | Q30494717 | ||
| Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL. | Q33551348 | ||
| A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis | Q33685619 | ||
| Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation | Q33732463 | ||
| Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities | Q33854076 | ||
| Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex | Q34101673 | ||
| Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation | Q34109986 | ||
| Functional analysis of the protein phosphatase activity of PTEN | Q34194118 | ||
| PTEN action in leukaemia dictated by the tissue microenvironment | Q34196262 | ||
| Aging, cellular senescence, and cancer | Q34199776 | ||
| The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms | Q34244242 | ||
| PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry | Q34248383 | ||
| Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. | Q48240280 | ||
| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells | Q48362692 | ||
| Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo | Q48722189 | ||
| PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. | Q51114244 | ||
| Tumor suppressor PTEN mediates sensing of chemoattractant gradients. | Q52546351 | ||
| Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. | Q53025231 | ||
| High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
| PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention | Q59067116 | ||
| Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity | Q63884125 | ||
| Impaired Fas response and autoimmunity in Pten+/- mice | Q73019160 | ||
| Disparate expression of the PTEN gene: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL) | Q73204033 | ||
| PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma | Q73374555 | ||
| Epigenetic silencing of the PTEN gene in melanoma | Q79834343 | ||
| PTEN promoter is methylated in a proportion of invasive breast cancers | Q80594418 | ||
| Posttranscriptional Regulation of PTEN by Competing Endogenous RNAs | Q89096006 | ||
| Pro-senescence therapy for cancer treatment | Q37893959 | ||
| Making new contacts: the mTOR network in metabolism and signalling crosstalk | Q38189969 | ||
| The Lilliputians and the Giant: An Emerging Oncogenic microRNA Network that Suppresses the PTEN Tumor Suppressor In Vivo | Q38234826 | ||
| Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases | Q38525479 | ||
| Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach | Q38629675 | ||
| Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer | Q38717692 | ||
| Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. | Q39100773 | ||
| SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane | Q39328325 | ||
| Senescence in Health and Disease. | Q39346510 | ||
| α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells | Q39545547 | ||
| Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. | Q39656536 | ||
| MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). | Q39728869 | ||
| Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. | Q39774233 | ||
| Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition | Q39905546 | ||
| PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability | Q39933367 | ||
| The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network | Q39948774 | ||
| Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis | Q40028787 | ||
| Regulation of the PTEN promoter by statins and SREBP. | Q40038228 | ||
| Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. | Q40122836 | ||
| PTEN is destabilized by phosphorylation on Thr366. | Q40143795 | ||
| PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. | Q40178894 | ||
| CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression | Q40179833 | ||
| Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. | Q40198370 | ||
| Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway | Q40198440 | ||
| c-Jun promotes cellular survival by suppression of PTEN. | Q40283457 | ||
| Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta | Q40384036 | ||
| Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. | Q40587498 | ||
| mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. | Q41290971 | ||
| mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis | Q41910369 | ||
| Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. | Q41912362 | ||
| Systemic elevation of PTEN induces a tumor-suppressive metabolic state | Q41968721 | ||
| PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth | Q42280031 | ||
| Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein | Q42485048 | ||
| MyosinV controls PTEN function and neuronal cell size. | Q42575733 | ||
| Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain | Q42827470 | ||
| Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins. | Q42865771 | ||
| Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity | Q42984934 | ||
| The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling | Q43848062 | ||
| PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils | Q44857079 | ||
| Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. | Q45345900 | ||
| Mechanistic insights into maintenance of high p53 acetylation by PTEN. | Q46035699 | ||
| PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation | Q46402658 | ||
| Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis | Q46458035 | ||
| PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. | Q46592766 | ||
| mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. | Q47110074 | ||
| Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. | Q47778719 | ||
| Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 | ||
| An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. | Q48239804 | ||
| P433 | issue | 9 | |
| P304 | page(s) | 547-562 | |
| P577 | publication date | 2018-09-01 | |
| P1433 | published in | Nature Reviews Molecular Cell Biology | Q1573120 |
| P1476 | title | The functions and regulation of the PTEN tumour suppressor: new modes and prospects | |
| P478 | volume | 19 |
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