| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0002-9440(10)65040-7 |
| P8608 | Fatcat ID | release_bfjknaumn5dutbsn66q7jduo5a |
| P932 | PMC publication ID | 1876937 |
| P698 | PubMed publication ID | 10793080 |
| P2093 | author name string | J A Lees | |
| G L Mutter | |||
| C Eng | |||
| D J Marsh | |||
| H Dralle | |||
| O Gimm | |||
| A Perren | |||
| P Komminoth | |||
| E Gil | |||
| B G Robinson | |||
| L Delbridge | |||
| R Hinze | |||
| J J Yeh | |||
| L P Weng | |||
| U Ziebold | |||
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Statistical aspects of the analysis of data from retrospective studies of disease | Q27860916 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Functions of the MDM2 oncoprotein | Q28138115 | ||
| Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN | Q28141881 | ||
| MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines | Q28256046 | ||
| Genetics of Cowden syndrome: through the looking glass of oncology | Q28262426 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 | ||
| Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast | Q35788322 | ||
| Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression | Q36067596 | ||
| Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways | Q36256326 | ||
| Cowden's Disease: A Case Report and Review of the Literature | Q39725803 | ||
| The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells | Q40993616 | ||
| Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent | Q41011329 | ||
| Antigen retrieval, signal amplification and intensification in immunohistochemistry | Q41386316 | ||
| Cowden's disease: analysis of fourteen new cases | Q41410446 | ||
| Cowden's disease (multiple hamartoma syndrome). | Q42470313 | ||
| Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 | ||
| Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas | Q44189691 | ||
| Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 | ||
| Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. | Q52180037 | ||
| Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. | Q53439669 | ||
| Frequent inactivation of PTEN/MMAC1 in primary prostate cancer | Q57240096 | ||
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies | Q57591287 | ||
| The WHO histological classification of thyroid tumors: a commentary on the second edition | Q69941661 | ||
| Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors | Q71482692 | ||
| Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways | Q73115528 | ||
| PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death | Q73229813 | ||
| Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas | Q74189160 | ||
| Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas | Q74418921 | ||
| Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma | Q77357530 | ||
| Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors | Q77470719 | ||
| Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma | Q77676753 | ||
| The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene | Q77726383 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1693-1700 | |
| P577 | publication date | 2000-05-01 | |
| P1433 | published in | The American Journal of Pathology | Q4744259 |
| P1476 | title | Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors | |
| P478 | volume | 156 |
| Q40556578 | A new human cell line, PDSS-26, from poorly differentiated synovial sarcoma, with unique chromosomal anomalies |
| Q34722525 | AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor |
| Q35853239 | ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells |
| Q36851633 | ATP modulates PTEN subcellular localization in multiple cancer cell lines. |
| Q53285916 | Abnormal distribution of hDlg and PTEN in premalignant lesions and invasive cervical cancer. |
| Q35009571 | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling |
| Q38381918 | Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility |
| Q36735198 | Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. |
| Q36622783 | Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma |
| Q54513531 | Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. |
| Q44350476 | BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels |
| Q33875062 | CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration |
| Q38330271 | Characterization of nuclear PTEN and its post translational modifications |
| Q36313163 | Class reunion: PTEN joins the nuclear crew. |
| Q28728155 | Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma |
| Q38963912 | Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development. |
| Q35083763 | Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization |
| Q36742319 | Correlation of immunohistochemical markers and BRAF mutation status with histological variants of papillary thyroid carcinoma in the Korean population |
| Q36774173 | Cowden disease: a review |
| Q46082313 | Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries |
| Q39890321 | DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells |
| Q33895317 | Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons |
| Q42232434 | Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer |
| Q36746834 | Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia |
| Q35745799 | Epigenetic PTEN silencing in malignant melanomas without PTEN mutation |
| Q34075238 | Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma |
| Q91583393 | FBXO22 degrades nuclear PTEN to promote tumorigenesis |
| Q36799818 | FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma |
| Q35842249 | Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas |
| Q33744696 | Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc |
| Q36429534 | Gene-expression profiling in differentiated thyroid cancer--a viable strategy for the practice of genomic medicine? |
| Q34783505 | Genetic insights into familial cancers-- update and recent discoveries |
| Q33905657 | Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults |
| Q35104084 | Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer |
| Q73410694 | Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues |
| Q38980829 | Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis |
| Q43038834 | Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase |
| Q42316444 | Importin-11 keeps PTEN safe from harm |
| Q28576729 | Inhibition of neuronal phenotype by PTEN in PC12 cells |
| Q30437740 | Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy |
| Q39297251 | Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN. |
| Q37351203 | Involution of latent endometrial precancers by hormonal and nonhormonal mechanisms |
| Q43249619 | Is PTEN loss associated with clinical outcome measures in human prostate cancer? |
| Q44645813 | Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells |
| Q79327416 | Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression |
| Q40464853 | Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. |
| Q35151381 | Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. |
| Q108127078 | MAPS: machine-assisted phenotype scoring enables rapid functional assessment of genetic variants by high-content microscopy |
| Q93048684 | MiRNAs Are Involved in Tall Cell Morphology in Papillary Thyroid Carcinoma |
| Q42752709 | MicroRNA Role in Thyroid Cancer Development |
| Q37022649 | Molecular biology of thyroid cancer initiation. |
| Q37110973 | Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. |
| Q35094749 | Molecular pathobiology of thyroid neoplasms |
| Q35208510 | Molecular pathogenesis of thyroid cancer |
| Q37337504 | Molecular pathology of thyroid cancer: diagnostic and clinical implications |
| Q47295202 | Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance. |
| Q40740686 | Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy |
| Q92906114 | Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions |
| Q30375908 | Multiple Meningiomas in a Patient with Cowden Syndrome. |
| Q35745875 | Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells |
| Q92207064 | Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus |
| Q38895958 | Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity |
| Q36528466 | New insight into the treatment of advanced differentiated thyroid cancer |
| Q42218359 | Nongenomic Mechanisms of PTEN Regulation |
| Q57591227 | Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma |
| Q28391204 | Nuclear PTEN levels and G2 progression in melanoma cells |
| Q24337323 | Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner |
| Q42076186 | Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation |
| Q79448445 | Nuclear PTEN: a tale of many tails |
| Q35574004 | Nuclear Phosphoinositides and Their Functions |
| Q36463127 | Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing story |
| Q74801555 | Nuclear lipid signaling |
| Q35120151 | Nuclear lipid signalling |
| Q28564702 | Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs |
| Q28277441 | Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells |
| Q38991018 | PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, inhibits anaplastic thyroid carcinoma cell proliferation and migration |
| Q40625753 | PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal |
| Q92316075 | PTEN Tumor-Suppressor: The Dam of Stemness in Cancer |
| Q34514602 | PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation |
| Q28217868 | PTEN associates with the vault particles in HeLa cells |
| Q40387100 | PTEN enters the nucleus by diffusion |
| Q74141759 | PTEN expression is maintained in sporadic colorectal tumours |
| Q51597378 | PTEN gene: a model for genetic diseases in dermatology. |
| Q44702044 | PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus |
| Q37139779 | PTEN in brain tumors |
| Q39337669 | PTEN inactivation by germline/somatic c.950_953delTACT mutation in patients with Lhermitte-Duclos disease manifesting progressive phenotypes |
| Q36361389 | PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome. |
| Q35747653 | PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers |
| Q57591147 | PTEN mutations are common in sporadic microsatellite stable colorectal cancer |
| Q26995683 | PTEN plasticity: how the taming of a lethal gene can go too far |
| Q35952035 | PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer |
| Q35146572 | PTEN signaling pathways in melanoma |
| Q50977901 | PTEN, Longevity and Age-Related Diseases. |
| Q54579801 | PTEN, pAKT, and pmTOR expression and subcellular distribution in primary renal cell carcinomas and their metastases. |
| Q91739141 | PTEN-knockdown disrupts the morphology, growth pattern and function of Nthy-Ori 3-1 cells by downregulating PAX8 expression |
| Q35087328 | PTEN: Multiple Functions in Human Malignant Tumors |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q37216319 | PTEN: a default gate-keeping tumor suppressor with a versatile tail |
| Q37270432 | PTEN: a new guardian of the genome. |
| Q37429785 | PTEN: new insights into its regulation and function in skin cancer |
| Q28203387 | PTEN: one gene, many syndromes |
| Q35203208 | PTEN: tumour suppressor, multifunctional growth regulator and more |
| Q37270440 | Post-translational regulation of PTEN. |
| Q64114534 | Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology |
| Q43456119 | Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China |
| Q24613810 | Protean PTEN: form and function |
| Q42807725 | Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN. |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q34707865 | Pten signaling in gliomas |
| Q42125233 | Pten, a protean tumor suppressor |
| Q36950684 | Regression of latent endometrial precancers by progestin infiltrated intrauterine device |
| Q42452984 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells |
| Q34741236 | Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis |
| Q37127301 | Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications |
| Q44504090 | SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles |
| Q57591241 | Silencing of thePTENtumor-suppressor gene in anaplastic thyroid cancer |
| Q38259905 | Study of PTEN subcellular localization |
| Q27022790 | Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders |
| Q34284733 | Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines |
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| Q33568168 | The role of podoplanin in the biology of differentiated thyroid cancers. |
| Q24290417 | The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation |
| Q45065846 | The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis |
| Q24650856 | The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization |
| Q73412063 | Thyroid cancer |
| Q57741132 | Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors |
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| Q33984914 | Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation |
| Q36442445 | Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes |
| Q35747343 | Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways |
| Q73943560 | [Thyroid carcinomas of the follicular epithelium: tumor markers and oncogenes] |
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