| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Antonio Di Cristofano | Q44022472 |
| P2093 | author name string | Zenglin Lian | |
| P2860 | cites work | Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | Q22253438 |
| Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 | Q22253866 | ||
| Phosphorylation of the PTEN tail regulates protein stability and function | Q22254305 | ||
| The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation | Q24290417 | ||
| Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N | Q24290689 | ||
| A transmembrane intracellular estrogen receptor mediates rapid cell signaling | Q24294726 | ||
| Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases | Q24305156 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells | Q24599234 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway | Q28139300 | ||
| Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles | Q28199232 | ||
| PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis | Q28207557 | ||
| Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE | Q28217217 | ||
| PTEN associates with the vault particles in HeLa cells | Q28217868 | ||
| Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta | Q28255046 | ||
| The biology and clinical relevance of the PTEN tumor suppressor pathway | Q28272157 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development | Q28512962 | ||
| Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD | Q28567152 | ||
| Role of translocation in the activation and function of protein kinase B | Q28609902 | ||
| Regulation of PTEN transcription by p53 | Q28646911 | ||
| A role for nuclear PTEN in neuronal differentiation. | Q29568319 | ||
| Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. | Q29977747 | ||
| Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase | Q30439814 | ||
| PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model | Q32069431 | ||
| Molecular pathogenesis of malignant gliomas | Q33635761 | ||
| Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation | Q33707626 | ||
| Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. | Q33714405 | ||
| Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity | Q33774967 | ||
| The multiple roles of PTEN in tumor suppression | Q33849727 | ||
| Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus | Q33874262 | ||
| Regulation of PTEN by Rho small GTPases | Q34406790 | ||
| The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. | Q34973870 | ||
| Nuclear lipids: new functions for old molecules? | Q35047567 | ||
| Nuclear lipid signalling | Q35120151 | ||
| PTEN signaling pathways in melanoma | Q35146572 | ||
| Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer | Q35445077 | ||
| Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors | Q35715762 | ||
| Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells | Q35745875 | ||
| PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers | Q35747653 | ||
| Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast | Q35788322 | ||
| Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors | Q35810225 | ||
| Human cancer, PTEN and the PI-3 kinase pathway | Q35812408 | ||
| Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression | Q36067596 | ||
| Activation of AKT kinases in cancer: implications for therapeutic targeting | Q36226730 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors | Q37693081 | ||
| Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein | Q40421181 | ||
| Akt1 contains a functional leucine-rich nuclear export sequence | Q40422051 | ||
| High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. | Q40425089 | ||
| Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells | Q40539604 | ||
| Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. | Q40615729 | ||
| Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines | Q40624250 | ||
| p27Kip1 modulates cell migration through the regulation of RhoA activation. | Q40795456 | ||
| Phosphatidylinositol 3-kinase translocates to the nucleus of osteoblast-like MC3T3-E1 cells in response to insulin-like growth factor I and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor alpha | Q40856235 | ||
| Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors | Q40868033 | ||
| Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation | Q42076186 | ||
| Myocardial Akt activation and gender: increased nuclear activity in females versus males | Q43618822 | ||
| Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes | Q44060026 | ||
| SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles | Q44504090 | ||
| Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium | Q44616560 | ||
| Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes | Q48014037 | ||
| Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study. | Q53663811 | ||
| The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia. | Q55341284 | ||
| Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma | Q57591227 | ||
| Monocytic Differentiation of HL-60 Cells Is Characterized by the Nuclear Translocation of Phosphatidylinositol 3-Kinase and of Definite Phosphatidylinositol-Specific Phospholipase C Isoforms | Q62017167 | ||
| Mutational Analysis of thePTENGene in Endometrial Carcinoma and Hyperplasia | Q63199224 | ||
| Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells | Q73263344 | ||
| P433 | issue | 50 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 7394-7400 | |
| P577 | publication date | 2005-11-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Class reunion: PTEN joins the nuclear crew | |
| P478 | volume | 24 |
| Q40184782 | A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth |
| Q34722525 | AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor |
| Q97534301 | Autophagy as a modulator of cell death machinery |
| Q36665424 | Carcinogenesis and transcriptional regulation through Maf recognition elements |
| Q41912188 | Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. |
| Q80347699 | Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation |
| Q42810841 | Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. |
| Q33895317 | Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons |
| Q42789722 | Differential localisation of PARP-1 N-terminal fragment in PARP-1(+/+) and PARP-1(-/-) murine cells |
| Q44801430 | Downregulation of PTEN expression in psoriatic lesions |
| Q24670959 | GPR30: A G protein-coupled receptor for estrogen |
| Q42399176 | Haloperidol induces the nuclear translocation of phosphatidylinositol 3'-kinase to disrupt Akt phosphorylation in PC12 cells. |
| Q39928785 | Inhibition of miR301 enhances Akt-mediated cell proliferation by accumulation of PTEN in nucleus and its effects on cell-cycle regulatory proteins. |
| Q30437740 | Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy |
| Q38266259 | Is Cytoplasmic PTEN a Specific Target for Neuronal Survival? |
| Q43249619 | Is PTEN loss associated with clinical outcome measures in human prostate cancer? |
| Q36798747 | Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation |
| Q37360580 | New diagnostic and molecular characteristics of malignant mesothelioma |
| Q79448445 | Nuclear PTEN: a tale of many tails |
| Q39159757 | Nuclear phosphoinositide regulation of chromatin. |
| Q24304276 | Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification |
| Q33406279 | Oscillations of the p53-Akt network: implications on cell survival and death |
| Q42371505 | Oxymatrine suppresses the growth and invasion of MG63 cells by up-regulating PTEN and promoting its nuclear translocation |
| Q34131044 | PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN |
| Q34514602 | PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation |
| Q37977769 | PTEN in DNA damage repair |
| Q36361389 | PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome. |
| Q37092758 | PTEN mutation, methylation and expression in breast cancer patients |
| Q37606460 | PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress |
| Q36710785 | PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex |
| Q50977901 | PTEN, Longevity and Age-Related Diseases. |
| Q36753139 | PTEN, more than the AKT pathway |
| Q36313181 | Perturbations of the AKT signaling pathway in human cancer |
| Q42807725 | Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN. |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q24337816 | Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases |
| Q38267480 | Relevance of SGK1 in structural, functional and molecular alterations produced by aldosterone in heart |
| Q27022790 | Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders |
| Q36137883 | The Optimization of Soluble PTEN Expression in Escherichia coli |
| Q34229795 | The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models |
| Q43515530 | The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia. |
| Q28542661 | The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noise |
| Q33904863 | The physiological impact of the serum and glucocorticoid-inducible kinase SGK1 |
| Q34503492 | Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets |
| Q24292946 | Ubiquitination regulates PTEN nuclear import and tumor suppression |
| Q28305068 | Where is mTOR and what is it doing there? |
| Q34545972 | mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging |
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