A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

scientific article published on 8 January 2007

A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046852045
P356DOI10.1038/SJ.ONC.1210175
P698PubMed publication ID17213812
P5875ResearchGate publication ID6587275

P2093author name stringP K Vogt
D L Durden
C Prince
G Denning
B Jean-Joseph
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PTEN function: how normal cells control it and tumour cells lose itQ24528114
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifsQ28564702
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
PTEN: a tumour suppressor that functions as a phospholipid phosphataseQ33594251
Mutations of the human PTEN geneQ33988995
Tumor suppressor PTEN acts through dynamic interaction with the plasma membraneQ34574432
Regulation of tumor suppressors by nuclear-cytoplasmic shuttlingQ35047240
Membrane-binding and activation mechanism of PTEN.Q35145882
PTEN controls tumor-induced angiogenesisQ35282160
Class reunion: PTEN joins the nuclear crew.Q36313163
Regulation of PTEN function as a PIP3 gatekeeper through membrane interactionQ36544446
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosisQ40372916
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault proteinQ40421181
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motifQ40601438
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapyQ40765673
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulationQ42076186
PI 3-kinase, mTOR, protein synthesis and cancerQ43786691
PTEN mutations in gliomas and glioneuronal tumors.Q47995275
PTEN and p53: who will get the upper hand?Q73086898
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
P304page(s)3930-3940
P577publication date2007-01-08
P1433published inOncogeneQ1568657
P1476titleA short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth
P478volume26

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cites work (P2860)
Q28546443A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity
Q43268885A motor driving PTEN.
Q38952567A new class of cancer-associated PTEN mutations defined by membrane translocation defects
Q34921883A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization
Q52715838A pathogenic role for germline PTEN variants which accumulate into the nucleus.
Q28305284A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Q35201003A unified nomenclature and amino acid numbering for human PTEN.
Q34722525AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor
Q36851633ATP modulates PTEN subcellular localization in multiple cancer cell lines.
Q26822064Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder
Q38330271Characterization of nuclear PTEN and its post translational modifications
Q34979031Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.
Q36724548Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia
Q33895317Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons
Q35166355Dissecting the cell to nucleus, perinucleus and cytosol.
Q38275377Engineering PTEN function: membrane association and activity
Q33854076Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities
Q37381874Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
Q90481635FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity
Q36006472Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
Q26797287Focus on PTEN Regulation
Q37252731Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.
Q90970814Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma
Q26772947Inherited PTEN mutations and the prediction of phenotype
Q35440540Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.
Q37351516Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
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Q36798747Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
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Q24298305NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane
Q34630287NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells
Q53685190Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival.
Q38652498Oncogenic PTEN functions and models in T-cell malignancies
Q42117421Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.
Q34202681PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control
Q38843254PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition
Q38541293PTEN genomic deletion defines favorable prognostic biomarkers in localized prostate cancer: a systematic review and meta-analysis.
Q28505099PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
Q49887901PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.
Q90429880PTEN: Tumor Suppressor and Metabolic Regulator
Q40436436Phosphatase and Tensin Homolog Is a Growth Repressor of Both Rhizoid and Gametophore Development in the Moss Physcomitrella patens.
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Q36998831Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
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Q37628945RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
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Q37188735ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes

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